The Genetics of Male Infertility

CoverPage......Page 1
front-matter......Page 2
TitlePage......Page 4
CopyRight......Page 5
Preface......Page 6
Contents......Page 8
Contributors......Page 12
SECTION 1: METHODS AND TOOLSFOR THE STUDY OF THEGENETICS OF MALE INFERTILITY......Page 18
1 The Genetics of MaleInfertility in the Eraof Genomics......Page 20
2 The Use of cDNA Librariesto Demonstrate a LinkageBetween Transcriptionand Translationin Male Germ Cells......Page 46
3 Considerations When UsingArray Technologiesfor Male Factor Assessment......Page 54
4 Microarray Analysisof a Large Numberof Single-NucleotidePolymorphisms in IndividualHuman Spermatozoa......Page 72
5 Physiological and Proteomic Approaches to Understanding Human Sperm Function......Page 94
6 Genetics of Idiopathic Male Infertility......Page 116
SECTION 2: MEIOSIS AND ERRORS OF MEIOSIS......Page 130
7 The Immunocytogenetics of Human Male Meiosis......Page 132
8 The Clinical Relevance of Sperm Aneuploidy......Page 146
9 DNA Repair Genes and Genomic Instability in Severe Male Factor Infertility......Page 162
SECTION 3: THE Y CHROMOSOME, DEVELOPMENT, SPERMATOGENESIS AND SPERM MATURATION......Page 182
10 Germ Cell-Specific Genes and Posttranscriptional Regulation in the Testis......Page 184
11 The Genetics of Cryptorchidism......Page 202
12 The Chromatoid Body and microRNA Pathways in Male Germ Cells......Page 216
13 Sperm Maturation in the Epididymis......Page 228
SECTION 4: CLINICAL APPLICATIONS OF THESTUDY OF THE GENETICS OFMALE INFERTILITY......Page 249
14 The Structure of the Y Chromosome and Its Role in Male Infertility......Page 250
15 Y Chromosome Microdeletions and Haplotypes......Page 256
16 The Genetics of Male Infertility......Page 268
17 The Future of the Diagnosis of Male (In)Fertility......Page 284
18 Polymorphisms and Male Infertility......Page 292
19 The Genetics of Abnormal Protamine Expression......Page 308
20 Chromatin Damage and Male Infertility......Page 320
21 Clinical Evaluation of the Genetics of Male Infertility......Page 334
INDEX......Page 346