The Evidence-based Guide to Antipsychotic Medications

Contents......Page 8
Contributors......Page 14
Acknowledgments......Page 18
Disclaimer......Page 20
1 Introduction......Page 22
2 Schizophrenia and Schizoaffective Disorder......Page 26
TREATMENT GOALS......Page 27
CLINICIAN-PATIENT RELATIONSHIP......Page 28
ANTIPSYCHOTIC MEDICATIONS......Page 29
TREATMENT OF SCHIZOPHRENIA......Page 41
TREATMENT OF SCHIZOAFFECTIVE DISORDER......Page 58
KEY CLINICAL POINTS......Page 60
REFERENCES......Page 61
BIPOLAR DISORDER......Page 66
KEY CLINICAL POINTS: BIPOLAR DISORDER......Page 74
PSYCHOTIC DEPRESSION......Page 75
KEY CLINICAL POINTS: PSYCHOTIC DEPRESSION......Page 79
TREATMENT-RESISTANT DEPRESSION......Page 80
NONPSYCHOTIC DEPRESSION......Page 82
OBSESSIVE-COMPULSIVE DISORDER......Page 84
KEY CLINICAL POINTS: OBSESSIVE-COMPULSIVE DISORDER......Page 92
GENERALIZED ANXIETY DISORDER......Page 93
KEY CLINICAL POINTS: GENERALIZED ANXIETY DISORDER......Page 101
POSTTRAUMATIC STRESS DISORDER......Page 102
SAFETY AND TOLERABILITY OF ANTIPSYCHOTICS IN MOOD AND ANXIETY DISORDERS: FUNDAMENTAL CONCEPTS......Page 111
REFERENCES......Page 113
4 Personality Disorders......Page 122
HOW PSYCHOSIS IS VIEWED IN PERSONALITY DISORDER......Page 123
HISTORICAL CONSIDERATIONS......Page 124
MECHANISM OF ACTION......Page 125
INDICATIONS AND EFFICACY......Page 126
CLINICAL USE......Page 127
GUIDELINES FOR SELECTION AND USE......Page 129
BORDERLINE PERSONALITY DISORDER......Page 131
SCHIZOTYPAL PERSONALITY DISORDER......Page 137
OTHER PERSONALITY DISORDERS......Page 142
KEY CLINICAL POINTS......Page 143
REFERENCES......Page 144
5 Substance Abuse Disorders......Page 146
SUBSTANCE-RELATED PSYCHOMOTOR AGITATION......Page 147
SUBSTANCE-ASSOCIATED PSYCHOTIC SYMPTOMS AND DISORDERS......Page 154
CO-OCCURRING DISORDERS......Page 157
SUBSTANCE USE DISORDERS......Page 162
KEY CLINICAL POINTS......Page 163
REFERENCES......Page 164
6 Use of Antipsychotics in Children and Adolescents......Page 166
INDICATIONS AND EFFICACY......Page 167
SECOND-GENERATION ANTIPSYCHOTICS......Page 184
FIRST-GENERATION ANTIPSYCHOTICS......Page 193
ANTIPSYCHOTIC TREATMENT OF PEDIATRIC PSYCHIATRIC DISORDERS......Page 201
KEY CLINICAL POINTS......Page 206
REFERENCES......Page 207
7 Use of Antipsychotics in Geriatric Patients......Page 212
GENERAL PRINCIPLES OF MEDICATION MANAGEMENT......Page 213
AGE-SPECIFIC ISSUES RELATED TO SIDE EFFECTS......Page 214
RISKS UNIQUE TO PATIENTS WITH DEMENTIA......Page 221
USE OF ANTIPSYCHOTIC MEDICATIONS IN LONG-TERM-CARE FACILITIES......Page 223
MEDICATION MANAGEMENT FOR PATIENTS WITH PSYCHIATRIC AND NEUROPSYCHIATRIC DISORDERS......Page 224
KEY CLINICAL POINTS......Page 233
REFERENCES......Page 234
8 Use of Antipsychotics in Medically Ill Patients......Page 236
MEDICAL CONSIDERATIONS IN THE USE OF ANTIPSYCHOTICS......Page 237
GENERAL CONDITIONS......Page 239
MEDICAL DISORDERS......Page 243
REFERENCES......Page 259
Appendix 1 Names, Strengths, and Formulations of First- and Second-Generation Antipsychotics......Page 262
Appendix 2 Pharmacokinetics of First- and Second-Generation Antipsychotics......Page 270
Appendix 3 Dosing and Administration of First- and Second-Generation Antipsychotics in Schizophrenia......Page 282
Appendix 4 Medical Workup When Initiating and Continuing First- and Second-Generation Antipsychotics......Page 296
Appendix 5 Medical Workup When Initiating and Continuing Clozapine......Page 300
Appendix 6 Use of First- and Second-Generation Antipsychotics for Agitation Due to Psychosis......Page 304
Appendix 7 Side Effects of Commonly Used Antipsychotics......Page 310
Appendix 8 Management of Treatment-Emergent Side Effects of Antipsychotic Medications......Page 312
Appendix 9 Use of First- and Second-Generation Antipsychotics in Pregnancy and Lactation......Page 318
A......Page 352
B......Page 357
C......Page 359
D......Page 363
E......Page 366
F......Page 367
G......Page 368
H......Page 369
I......Page 371
M......Page 372
N......Page 374
O......Page 375
P......Page 378
Q......Page 381
R......Page 382
S......Page 384
T......Page 389
Z......Page 391