The EBMT Handbook: Hematopoietic Stem Cell Transplantation and Cellular Therapies

Front Matter ....Pages i-xl
Front Matter ....Pages 1-1
 HSCT: Historical Perspective  (Rainer Storb)....Pages 3-9
 The EBMT: History, Present, and Future  (Alois Gratwohl, Mohamad Mohty, Jane Apperley)....Pages 11-17
 The Role of Unrelated Donor Registries in HSCT  (Irina Evseeva, Lydia Foeken, Alejandro Madrigal)....Pages 19-25
 The HSCT Unit  (Walid Rasheed, Dietger W. Niederwieser, Mahmoud Aljurf)....Pages 27-34
 JACIE Accreditation of HSCT Programs  (Riccardo Saccardi, Eoin McGrath, John A. Snowden)....Pages 35-40
 Statistical Methods in HSCT and Cellular Therapies  (Simona Iacobelli, Liesbeth C. de Wreede)....Pages 41-46
Front Matter ....Pages 47-47
 Biological Properties of HSC: Scientific Basis for HSCT  (Alessandro Aiuti, Serena Scala, Christian Chabannon)....Pages 49-56
 Biological Properties of Cells Other Than HSCs  (Attilio Bondanza, Ulrike Koehl, Andrea Hoffmann, Antoine Toubert)....Pages 57-60
 Histocompatibility  (Eric Spierings, Katharina Fleischhauer)....Pages 61-68
 Clinical and Biological Concepts for Mastering Immune Reconstitution After HSCT: Toward Practical Guidelines and Greater Harmonization  (Jürgen Kuball, Jaap Jan Boelens)....Pages 69-74
Front Matter ....Pages 75-75
 Evaluation and Counseling of Candidates  (Enric Carreras, Alessandro Rambaldi)....Pages 77-86
 Donor Selection for Adults and Pediatrics  (Francis Ayuk, Adriana Balduzzi)....Pages 87-97
 Conditioning  (Arnon Nagler, Avichai Shimoni)....Pages 99-107
 Bone Marrow Harvesting for HSCT  (Norbert Claude Gorin)....Pages 109-115
 Mobilization and Collection of HSC  (Kai Hübel)....Pages 117-122
 Collection of HSC in Children  (Volker Witt, Christina Peters)....Pages 123-126
 Processing, Cryopreserving and Controlling the Quality of HSCs  (Patrick Wuchter)....Pages 127-130
 Procurement and Management of Cord Blood  (Sergio Querol, Vanderson Rocha)....Pages 131-136
 Graft Manipulation  (Michael Schumm, Peter Lang, Rupert Handgretinger)....Pages 137-142
 Documentation of Engraftment and Chimerism After HSCT  (Peter Bader)....Pages 143-147
 Short- and Long-Term Controls After HSCT  (Montserrat Rovira, Maria Suárez-Lledó)....Pages 149-153
Front Matter ....Pages 155-155
 Vascular Access  (Simone Cesaro, Federica Minniti)....Pages 157-161
 Transfusion Support  (Hubert Schrezenmeier, Sixten Körper, Britta Höchsmann, Christof Weinstock)....Pages 163-169
 Nutritional Support  (Annic Baumgartner, Philipp Schuetz)....Pages 171-176
 GVHD Prophylaxis (Immunosuppression)  (David Michonneau, Gérard Socié)....Pages 177-182
 Management ATG (SIRS)  (Francesca Bonifazi)....Pages 183-187
 Infection Control and Isolation Procedures  (Malgorzata Mikulska)....Pages 189-195
 General Management of the Patient: Specific Aspects of Children  (Francesca Riccardi, Elio Castagnola)....Pages 197-205
 Vaccinations  (Rafael de la Cámara)....Pages 207-219
 Psychological Morbidity and Support  (Alice Polomeni, Enrique Moreno, Frank Schulz-Kindermann)....Pages 221-227
 Clinically Relevant Drug Interactions in HSCT  (Tiene Bauters)....Pages 229-235
 Role of Nursing in HSCT  (Aleksandra Babic, John Murray)....Pages 237-243
 Ethical Issues in HSCT  (Khaled El-Ghariani, Jean-Hugues Dalle)....Pages 245-249
 Quality of Life Assessment After HSCT for Pediatric and Adults  (Anna Barata, Heather Jim)....Pages 251-256
Front Matter ....Pages 257-257
 Neutropenic Fever  (Malgorzata Mikulska)....Pages 259-264
 Bacterial Infections  (Diana Averbuch)....Pages 265-272
 Invasive Fungal Infections  (Johan A. Maertens)....Pages 273-280
 Viral Infections  (Per Ljungman, Jan Styczynski, Hermann Einsele)....Pages 281-290
 Other Life-Threatening Infections  (Rodrigo Martino)....Pages 291-299
 Bleeding and Thrombotic Complications  (Shruti Chaturvedi, Binsah George, Bipin N. Savani)....Pages 301-306
 Graft Failure  (David Valcárcel, Anna Sureda)....Pages 307-313
 Early Complications of Endothelial Origin  (Enric Carreras, Maribel Diaz-Ricart)....Pages 315-322
 Acute Graft-Versus-Host Disease  (Ernst Holler, Hildegard Greinix, Robert Zeiser)....Pages 323-330
 Chronic Graft-Versus-Host Disease  (Daniel Wolff, Anita Lawitschka)....Pages 331-345
 Post transplant Lymphoproliferative Syndromes  (Jan Styczynski, Sebastian Giebel)....Pages 347-352
 Iron Overload  (Emanuele Angelucci)....Pages 353-356
 Secondary Neoplasia (Other than PTLPS)  (André Tichelli)....Pages 357-363
Front Matter ....Pages 365-365
 Ocular and Oral Complications  (Shahrukh K. Hashmi)....Pages 367-371
 Hepatic Complications  (Tapani Ruutu, Enric Carreras)....Pages 373-379
 Gastrointestinal Complications  (Grzegorz W. Basak)....Pages 381-386
 Haemorrhagic Cystitis and Renal Dysfunction  (Simone Cesaro)....Pages 387-391
 Noninfectious Pulmonary Complications  (Enric Carreras, Kenneth R. Cooke)....Pages 393-401
 Neurological Complications  (Rémy Duléry)....Pages 403-407
 Skin, Hair and Musculoskeletal Complications  (Francis Ayuk, Bipin N. Savani)....Pages 409-413
 Cardiovascular Diseases and Metabolic Syndrome  (Diana M. Greenfield, John A. Snowden)....Pages 415-420
 Endocrine Disorders, Fertility and Sexual Health  (Nina Salooja, Zeev Shoham, Jean-Hugues Dalle)....Pages 421-427
Front Matter ....Pages 429-429
 Monitoring Minimal Residual Disease in ALL and AML  (Peter Bader, Hermann Kreyenberg, Gert Ossenkoppele)....Pages 431-436
 Prevention and Treatment of Relapse by Drugs  (Nicolaus Kröger)....Pages 437-442
 Delayed Transfer of Immune Cells or the Art of Donor Lymphocyte Infusion  (J. H. Frederik Falkenburg, Christoph Schmid, Hans Joachim Kolb, Franco Locatelli, Jürgen Kuball)....Pages 443-448
 Cellular Therapy with Engineered T Cells, Efficacy and Side Effects  (Attilio Bondanza, Chiara Bonini, Boris Fehse, Michael Hudecek)....Pages 449-456
 Mechanisms of Immune Resistance  (Luca Vago, Francesco Dazzi)....Pages 457-460
 Regulatory Aspects of ATMP Versus Minimally Manipulated Immune Cells  (Eoin McGrath, Christian Chabannon)....Pages 461-464
Front Matter ....Pages 465-465
 At-Home HSCT  (Francesc Fernandez-Avilés, Gonzalo Gutiérrez-García)....Pages 467-471
 Umbilical Cord Blood Transplantation in Children and Adults  (Jaime Sanz, Paul Veys, Vanderson Rocha)....Pages 473-478
 Haploidentical HSCT  (Fabio Ciceri, Andrea Bacigalupo, Arjan Lankester, Alice Bertaina)....Pages 479-486
 Photopheresis in Adults and Pediatrics  (Hildegard Greinix)....Pages 487-491
 Overweight and Obese Patients  (Claudia Langebrake)....Pages 493-498
 HSCT in Elderly Patients  (Rafael F. Duarte, Isabel Sánchez-Ortega)....Pages 499-503
Front Matter ....Pages 505-505
 Acute Myeloid Leukemia in Adults  (Jurjen Versluis, Jan J. Cornelissen, Charles Craddock, Miguel Á. Sanz, Jonathan Canaani, Arnon Nagler)....Pages 507-521
 Acute Myeloid Leukemia in Children  (Brenda E. S. Gibson, Martin G. Sauer, Persis Amrolia)....Pages 523-530
 Acute Lymphoblastic Leukemia in Adults  (Matthias Stelljes, David I. Marks)....Pages 531-538
 Acute Lymphoblastic Leukemia in Children and Adolescents  (Christina Peters, Franco Locatelli, Peter Bader)....Pages 539-545
 Myelodysplastic Syndromes  (Marie Robin, Theo de Witte)....Pages 547-556
 Pediatric MDS Including Refractory Cytopenia and Juvenile Myelomonocytic Leukemia  (Charlotte M. Niemeyer)....Pages 557-560
 Myelodysplastic/Myeloproliferative Neoplasms  (Francesco Onida, Yves Chalandon)....Pages 561-568
 Myeloproliferative Neoplasms  (Nicolaus Kröger, Yves Chalandon)....Pages 569-578
 Severe Aplastic Anemia and PNH  (Régis Peffault de Latour, Antonio Risitano, Carlo Dufour)....Pages 579-585
 Fanconi’s Anemia and Other Hereditary Bone Marrow Failure Syndromes  (Cristina Díaz de Heredia, Marc Bierings, Jean-Hugues Dalle, Francesca Fioredda, Brigitte Strahm)....Pages 587-593
 Hemoglobinopathies (Sickle Cell Disease and Thalassemia)  (Barbara Cappelli, Eliane Gluckman, Khaled Ghanem, Miguel R. Abboud)....Pages 595-601
 Multiple Myeloma  (Joan Bladé, Benedetto Bruno, Mohamad Mohty)....Pages 603-607
 Systemic Light Chain Amyloidosis  (Monique Minnema, Stefan Schönland)....Pages 609-614
 POEMS Syndrome and Disease Produced by Other Monoclonal Immunoglobulins  (Gordon Cook, Montserrat Rovira)....Pages 615-619
 Follicular Lymphoma  (Stephen Robinson)....Pages 621-626
 Chronic Lymphocytic Leukemia  (Johannes Schetelig, Peter Dreger)....Pages 627-632
 Diffuse Large B-Cell Lymphoma  (Norbert Schmitz, Matthias Stelljes, Ali Bazarbachi)....Pages 633-641
 Mantle Cell Lymphoma  (Sascha Dietrich)....Pages 643-646
 Other T- and B-Aggressive Lymphomas and Lymphomas Associated with HIV  (Kai Hübel, Silvia Montoto)....Pages 647-651
 Classical Hodgkin’s Lymphoma  (Anna Sureda, Carmen Martínez)....Pages 653-662
 Primary Immunodeficiencies  (Michael Albert, Arjan Lankester, Andrew Gennery)....Pages 663-670
 Inborn Errors of Metabolism and Osteopetrosis  (Robert Wynn, Ansgar Schulz)....Pages 671-676
 Autoimmune Disease  (Tobias Alexander, Basil Sharrack, Montserrat Rovira, Dominique Farge, John A. Snowden)....Pages 677-683
 Solid Tumours  (Ruth Ladenstein, Evgenia Glogova, Francesco Lanza)....Pages 685-698
Back Matter ....Pages 699-702