The Challenge of Highly Pathogenic Microorganisms: Mechanisms of Virulence and Novel Medical Countermeasures

Front Matter....Pages i-xviii
The Anthrax Capsule: Role in Pathogenesis and Target for Vaccines and Therapeutics....Pages 1-9
Proteomic Studies of Bacillus anthracis Reveal In Vitro CO 2 -Modulation and Expression During Infection of Extracellular Proteases....Pages 11-22
Dynamics of Bacillus anthracis Infection and Control Mechanisms....Pages 23-29
Survival and Trafficking of Yersinia pestis in Non-acidified Phagosomes in Murine Macrophages....Pages 31-44
The Inverse Relationship Between Cytotoxicity of Y. pestis and Its Virulence....Pages 45-55
The NlpD Lipoprotein of Yersinia pestis is Essential for Cell Separation and Virulence....Pages 57-65
Dissection of the Functions of the IglC Protein of Francisella tularensis ....Pages 67-75
 Yersinia pestis Lipopolysaccharide in Host-Pathogen Interactions....Pages 77-87
The Interactions Between Pathogens and Dendritic Cells: From Paralysis of Cells to Their Recruitment for Bacterial Colonization....Pages 89-98
Comparative Approaches to Identify Host Factors Specifically Targeted by Yersinia pestis During the Infectious Process....Pages 99-106
Poxvirus Entry into Host Cells....Pages 107-113
Role of A33R Amino-Acid 118L in the Interactions of Vaccinia Virus with the Host....Pages 115-123
Inhibitors of Innate Immunity from Vaccinia Virus....Pages 125-134
 Brucella Species Synchronize Their Life Cycle to the Gestation Cycle of Their Ruminant Hosts....Pages 135-146
MMP-9 as a Marker for Vaccinia Virus Related Encephalitis....Pages 147-155
Epidemic Cowpox Virus Infections in Germany....Pages 157-164
The Two Partner SecretionTwo Partner Secretion Transporters of Yersinia pestis: Cloning, Immunogenicity and In Vivo Expression Following Airway Infection....Pages 165-172
Genetic Detection of Vesicle Forming Pathogens by Arrayed Primer Extension (APEX)....Pages 173-182
Subtyping Biothreat Bacterial Pathogens....Pages 183-190
A Rapid Method for Bacillus anthracis Genotyping....Pages 191-198
Tularemia – A Disease with an Uncertain Impact on Public Health....Pages 199-206
Consequences of Antibiotic Treatment of Francisella tularensis Airways Infections....Pages 207-212
Novel Live Vaccine Candidates Against Airborne Francisella tularensis ....Pages 213-218
Effect of Disruption of mglA on the Virulence and Immunogenicity of the Francisella tularensis Live Vaccine Strain (LVS)....Pages 219-227
Data Mining, Bioinformatic and Immunoinformatic Analyses of Francisella tularensis Schu S4 Genome in Search for Novel Vaccine Candidates....Pages 229-243
Modified Vaccinia Virus Ankara (MVA) based Vaccines – Immunostimulatory and Protective Capacity....Pages 245-251
Therapeutic Potential of Vaccinia Hyper Immune Sera in Mouse Models of Lethal Orthopoxviruses Infection....Pages 253-260
A Live Plaque Vaccine Candidate with Improved Safety and Immunogenecity....Pages 261-268
Protection Against Plague Afforded by Treatment with Polyclonal αLcrV and αF1 Antibodies....Pages 269-274
Combination of Anthrax-Toxin Neutralizing Antibodies: Analysis of Synergism/Antagonism Effect....Pages 275-285
The Efficacy of Antibiotic Treatment to Cure Guinea Pigs Intranasally Infected with Bacillus anthracis Spores....Pages 287-293
Back Matter....Pages 295-306
....Pages 307-314