The Cerebellum and its Disorders

Cover......Page 1
Frontmatter......Page 2
Contents......Page 6
List of contributors......Page 10
Preface......Page 18
Acknowledgments......Page 20
Foreword by Sid Gilman......Page 22
PART I - INTRODUCTION......Page 24
1 - Embryology of the cerebellum......Page 26
2 - Neuroanatomy of the cerebellum......Page 29
3 - High-resolution cerebellar anatomy......Page 53
4 - Neurotransmitters in the cerebellum......Page 61
5 - Structure and function of the cerebellum......Page 72
PART II - THEORIES OF CEREBELLAR CONTROL......Page 90
6 - Models of cerebellar function......Page 92
PART III - CLINICAL SIGNS AND PATHOPHYSIOLOGICAL CORRELATIONS......Page 118
7 - Clinical signs of cerebellar disorders......Page 120
8 - Pathophysiology of clinical cerebellar signs......Page 144
9 - The role of the cerebellum in affect and psychosis......Page 159
PART IV - SPORADIC DISEASES......Page 182
10 - Congenital malformations of the cerebellum and posterior fossa......Page 184
11 - Multiple system atrophy and idiopathic late-onset cerebellar ataxia......Page 201
12 - Corticobasal degeneration......Page 221
13 - Cerebellar stroke......Page 225
14 - Immune diseases......Page 251
15 - Infectious diseases: radiology and treatment of cerebellar abscesses......Page 260
16 - Other infectious diseases......Page 271
17 - Cerebellar disorders in cancer......Page 288
18 - Posterior fossa trauma......Page 311
19 - Thyroid hormone and cerebellar development......Page 328
20 - Endocrine disorders: clinical aspects......Page 339
PART V - TOXIC AGENTS......Page 348
21 - Alcohol toxicity in the cerebellum: fundamental aspects......Page 350
22 - Alcohol toxicity in the cerebellum: clinical aspects......Page 359
23 - Other cerebellotoxic agents......Page 365
PART VI - ADVANCES IN GRAFTS......Page 390
24 - Cerebellar grafts......Page 392
PART VII - NEUROPATHOLOGY......Page 408
25 - Neuropathology of the inherited ataxias......Page 410
PART VIII - DOMINANTLY INHERITED PROGRESSIVE ATAXIAS......Page 430
26 - Spinocerebellar ataxia type 1......Page 432
27 - Spinocerebellar ataxia type 2......Page 442
28 - Spinocerebellar ataxia type 3......Page 451
29 - Spinocerebellar ataxia type 4......Page 463
30 - Spinocerebellar ataxia type 5......Page 468
31 - Spinocerebellar ataxia type 6......Page 474
32 - Autosomal dominant cerebellar ataxia with progressive pigmentary macular dystrophy......Page 482
33 - Spinocerebellar ataxia type 8......Page 492
34 - Dentatorubral-pallidoluysian atrophy......Page 504
35 - Molecular mechanisms of triplet repeat expansions in ataxias......Page 514
PART IX - RECESSIVE ATAXIAS......Page 526
36 - Friedreich\'s ataxia......Page 528
37 - Early-onset inherited ataxias......Page 542
38 - Ataxia telangiectasia and variants......Page 554
39 - Ataxia in mitochondrial disorders......Page 571
40 - Episodic ataxias as ion channel diseases......Page 585
Index......Page 596