Ten Years of Progress in GW/P Body Research

Front Matter....Pages i-xi
Introduction: The GW Body Story as an Example of Autoantibodies with Significant Impacts to Molecular Cell Biology....Pages 1-4
The Discovery of GW Bodies....Pages 5-21
The Discovery and Analysis of P Bodies....Pages 23-43
Autoantibodies to Argonaute 2 (Su Antigen)....Pages 45-59
GW/P-Bodies and Autoimmune Disease....Pages 61-70
Function of GW182 and GW Bodies in siRNA and miRNA Pathways....Pages 71-96
Post-transcriptional Stimulation of Gene Expression by MicroRNAs....Pages 97-126
Gawky (GW) is the Drosophila melanogaster GW182 Homologue....Pages 127-145
The Role of GW182 Proteins in miRNA-Mediated Gene Silencing....Pages 147-163
Quantifying Argonaute Proteins In and Out of GW/P-Bodies: Implications in microRNA Activities....Pages 165-182
Deadenylation and P-Bodies....Pages 183-195
Relationship of GW/P-Bodies with Stress Granules....Pages 197-211
Relationship of Other Cytoplasmic Ribonucleoprotein Bodies (cRNPB) to GW/P Bodies....Pages 213-242
An SNP in the Trinucleotide Repeat Region of the TNRC6A Gene Maps to a Major TNGW1 Autoepitope in Patients with Autoantibodies to GW182....Pages 243-259
Reflections on Ten Years of History of, and Future Prospects for, GW182 and GW/P Body Research....Pages 261-270
Back Matter....Pages 271-276