Targeting the DNA Damage Response for Anti-Cancer Therapy

Front Matter ....Pages i-ix
 Targeting DNA Repair in Anti-Cancer Treatments  (Thomas Helleday)....Pages 1-9
 The DNA Damage Response: Roles in Cancer Etiology and Treatment  (Laura R. Butler, Oren Gilad, Eric J. Brown)....Pages 11-33
 Control of DNA Replication by ATR  (Emilio Lecona, Oscar Fernández-Capetillo)....Pages 35-61
 Targeting ATR for Cancer Therapy: Profile and Expectations for ATR Inhibitors  (Nicola Curtin, John Pollard)....Pages 63-97
 Targeting ATR for Cancer Therapy: ATR-Targeted Drug Candidates  (Magnus T. Dillon, Kevin J. Harrington)....Pages 99-127
 ATM: Its Recruitment, Activation, Signalling and Contribution to Tumour Suppression  (Atsushi Shibata, Penny Jeggo)....Pages 129-154
 Pre-clinical Profile and Expectations for Pharmacological ATM Inhibition  (Anika M. Weber, Anderson J. Ryan)....Pages 155-183
 Targeting ATM for Cancer Therapy: Prospects for Drugging ATM  (Ian Hickson, Kurt G. Pike, Stephen T. Durant)....Pages 185-208
 Targeting CHK1 for Cancer Therapy: Rationale, Progress and Prospects  (David A. Gillespie)....Pages 209-240
 Preclinical Profiles and Contexts for CHK1 and CHK2 Inhibitors  (Ian Collins, Michelle D. Garrett)....Pages 241-276
 Clinical Development of CHK1 Inhibitors  (Alvaro Ingles Garces, Udai Banerji)....Pages 277-314
 Established and Emerging Roles of the DNA-Dependent Protein Kinase Catalytic Subunit (DNA-PKcs)  (Edward J. Bartlett, Susan P. Lees-Miller)....Pages 315-338
 Targeting DNA-PK as a Therapeutic Approach in Oncology  (Celine Cano, Suzannah J. Harnor, Elaine Willmore, Stephen R. Wedge)....Pages 339-357
 Dbait: A New Concept of DNA Repair Pathways Inhibitor from Bench to Bedside  (Marie Dutreix, Flavien Devun, Nirmitha Herath, Patricia Noguiez-Hellin)....Pages 359-373
 Alternative Non-homologous End-Joining: Mechanisms and Targeting Strategies in Cancer  (Pratik Nagaria, Feyruz V. Rassool)....Pages 375-400
Back Matter ....Pages 401-401