Targeting of Drugs 2: Optimization Strategies

Front Matter....Pages i-viii
Biological Dispersion and the Design of Site-Specific Protein Therapeutic Systems....Pages 1-19
Recombinant Ligand-Toxin Conjugates, Domain Engineering and the Search for Targeted Pharmaceuticals....Pages 21-27
Extravascular Diffusion and Convection of Antibodies in Tumors....Pages 29-38
Antitumor Effects of Six Ricin A-Chain Immunotoxins of Potential Use in the Treatment of Hodgkin’S Disease....Pages 39-47
Enhancement of Hormone Activity by Monoclonal Antibodies....Pages 49-56
Modeling of Cell Membrane Targeting: Specific Recognition, Binding, and Protein Domain Formation in Ligand-Containing Model Biomembranes....Pages 57-76
Endocytosis of Cell Surface Molecules and Intracellular Delivery of Materials Encapsulated in Targeted Liposomes....Pages 77-86
Tissue Specific Serum Opsonins and Phagocytosis of Liposomes....Pages 87-94
Liposome Targeting to Tumor Cells in Vivo....Pages 95-101
Stabilization of Lipid Microstructures: Fundamentals and Applications....Pages 103-115
Non-Ionic Surfactant Vesicles as Carriers of Doxorubicin....Pages 117-126
Targeted Therapy of Liver Carcinoma....Pages 127-135
Drug Delivery Systems: The Industrial View....Pages 137-153
Controlled Delivery to the Brain....Pages 155-163
Polymeric Delivery Systems....Pages 165-175
Back Matter....Pages 177-185