Targeted Therapies in Cancer: Myth or Reality?

Front Matter....Pages i-viii
Causality in Medicine....Pages 1-4
The Evolution of the Biomedical Paradigm in Oncology: Implications for Cancer Therapy....Pages 5-18
Anticancer Drug Discovery and Development....Pages 19-42
Beyond VEGF: Targeting Tumor Growth and Angiogenesis via Alternative Mechanisms....Pages 43-53
Aurora Kinases and Their Inhibitors: More Than One Target and One Drug....Pages 54-73
Signalling Pathways and Adhesion Molecules as Targets for Antiangiogenesis Therapy in Tumors....Pages 74-87
Developing T-Cell Therapies for Cancer in an Academic Setting....Pages 88-99
Anticancer Cell Therapy with TRAIL-Armed CD34 + Progenitor Cells....Pages 100-111
Linking Inflammation Reactions to Cancer: Novel Targets for Therapeutic Strategies....Pages 112-127
Clinical Development of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors: What Lessons Have We Learned?....Pages 128-143
GIST As the Model of Paradigm Shift Towards Targeted Therapy of Solid Tumors: Update and Perspective on Trial Design....Pages 144-154
Monoclonal Antibodies in the Treatment of Malignant Lymphomas....Pages 155-176
Molecular Network Analysis using Reverse Phase Protein Microarrays for Patient Tailored Therapy....Pages 177-186
Back Matter....Pages 187-191