Systems Biology: Definitions and Perspectives

Systems Biology: Did we know it all along?....Pages 3-9
From isolation to integration, a systems biology approach for building the Silicon Cell....Pages 13-30
Kinetic modelling of the E. coli metabolism....Pages 31-67
Metabolic Control Analysis....Pages 69-80
No music without melody: How to understand biochemical systems by understanding their dynamics....Pages 81-93
Mesoscopic kinetics and its applications in protein synthesis....Pages 95-18
What is systems biology? From genes to function and back....Pages 119-141
Mechanistic and modular approaches to modeling and inference of cellular regulatory networks....Pages 143-159
Modeling the E. coli cell: The need for computing, cooperation, and consortia....Pages 163-189
Metabolic flux analysis: A key methodology for systems biology of metabolism....Pages 191-214
Metabolic networks: biology meets engineering sciences....Pages 215-234
Integration of metabolic and signaling networks....Pages 235-256
Mathematical modelling of the Wnt-pathway....Pages 259-275
Modelling signalling pathways – a yeast approach....Pages 277-302
Systems biology of the yeast cell cycle engine....Pages 305-324
A modular systems biology analysis of cell cycle entrance into S-phase....Pages 325-347
Systems biology of apoptosis....Pages 349-372
Scientific and technical challenges for systems biology....Pages 373-385
Systems Biology: necessary developments and trends....Pages 389-402