Synaptic Plasticity and the Mechanism of Alzheimer's Disease

Front Matter....Pages I-XII
Permanence of the Synapse and Molecular Instability....Pages 1-18
Cellular Biology of AMPA Receptor Trafficking and Synaptic Plasticity....Pages 19-35
Imaging of Experience-Dependent Structural Plasticity in the Mouse Neocortex in vivo....Pages 37-49
Synapse Loss, Synaptic Plasticity and the Postsynaptic Density....Pages 51-62
Impact of Beta Amyloid on Excitatory Synaptic Transmission and Plasticity....Pages 63-68
Quantitative Neuropathology in Alzheimer’s Mouse Models....Pages 69-73
Multiple Levels of Synaptic Regulation by NMDA-type Glutamate Receptor in Normal and Disease States....Pages 75-87
Soluble Oligomers of the Amyloid β-Protein: Impair Synaptic Plasticity and Behavior....Pages 89-102
Why Alzheimer’s is a Disease of Memory: Synaptic Targeting by Pathogenic Aβ Oligomers (ADDLs)....Pages 103-132
Synaptic Transmission Dynamically Modulates Interstitial Fluid Amyloid-β Levels....Pages 133-143
Aβ-Induced Toxicity Mediated by Caspase Cleavage of the Amyloid Precursor Protein (APP)....Pages 145-155
Long-Term Potentiation and Aβ: Targeting Aβ Species, Cellular Mechanisms and Putative Receptors....Pages 157-167
Genes, Synapses and Autism Spectrum Disorders....Pages 169-179
Back Matter....Pages 181-183