Surgical Research

Content: 
Contributors, Pages xix-xxv
Foreword, Pages xxvii-xxx, Jonathan Rhoads
Preface, Pages xxxi-xxxii, Wiley W. Souba, Douglas W. Wilmore
1 - Getting Started, Pages 1-2, James C. Thompson
2 - Assessing Available Information, Pages 3-8, Edward E. Whang, Stanley W. Ashley
3 - Organizing and Preliminary Planning for Surgical Research, Pages 9-11, Michael W. Mulholland
4 - Writing a Protocol: Animals, Humans, and Use of Biologic, Chemical, and Radiologic Agents, Pages 13-22, Wayne R. Patterson
5 - Grantsmanship, Pages 23-28, B. Mark Evers
6 - Informed Consent and the Protection of Human Research Subjects: Historical Perspectives and Guide to Current United States Regulations, Pages 29-45, Mary Jane Kagarise, George F. Sheldon
7 - Animal Care and Maintenance, Pages 47-61, David Lee-Parritz
8 - Funding Strategies and Agencies: Academic-Industrial Relationships; Intellectual Property, Pages 63-69, Josef E. Fischer
9 - Statistical Considerations, Pages 71-80, David T. Mauger, Gordon L. Kauffman Jr.
10 - Use of Nonexperimental Studies to Evaluate Surgical Procedures and Other Interventions: The Challenge of Risk Adjustment, Pages 81-99, Michael Shwartz, Arlene S. Ash, Lisa I. Iezzoni
11 - Measuring Surgical Outcomes, Pages 101-113, Jean Y. Liu, John D. Birkmeyer
12 - Design of Clinical Trials, Pages 115-125, Kenneth K. Tanabe
13 - Using Administrative Data for Clinical Research, Pages 127-136, John D. Birkmeyer
14 - Research in the Intensive Care Unit: Ethical and Methodological Issues, Pages 137-154, Philip S. Barie, Matthew D. Bacchetta, Joseph J. Fins, Soumitra R. Eachempati
15 - Research in the Operating Room, Pages 155-166, Liane Feldman, Jeffrey S. Barkun, Jonathan L. Meakins
16 - Effects of Age and Gender, Pages 167-174, James M. Watters, Keith O\'Rourke
17 - Strategies, Principles, and Techniques Using Transgenic and Knockout Mouse Models, Pages 175-191, Jeffrey M. Arbeit
18 - Tissue Culture, Cell Growth, and Analysis, Pages 193-206, Andrea L. Nestor, James Willey, David C. Allison
19 - Hematopoietic Stem Cells: Basic Concepts and Applications to Surgical Research, Pages 207-215, Henry E. Rice, Robert W. Storms, Clay Smith, Alan W. Flake
20 - Basic Molecular Biological Methods in Surgical Research: Genetic Library Construction, Screening, and DNA Sequencing, Pages 217-232, Steve F. Abcouwer
21 - Transcription, Pages 233-251, George P. Yang, Ronald J. Weigel
22 - Signal Transduction and Apoptosis, Pages 253-270, Tanya K. Meyer, William G. Cance
23 - Mechanisms and Regulation of Eukaryotic Protein Synthesis, Pages 271-284, Theresa L. Eisenbraun, Patricia M. Scott, Gregory D. Kennedy, John E. Niederhuber
24 - Organelle Studies: Mitochondria, Golgi, and Endoplasmic Reticulum, Pages 285-296, Anirban Banerjee, Thomas N. Robinson, Fabia Gamboni-Robertson, Charles B. Cairns, Rene J.P. Musters
25 - Membrane Biology and Biophysics, Pages 297-305, Raphael C. Lee, Jurgen Hannig
26 - Molecular Epidemiology: Beyond Gene Discovery to Clinical Diagnostic Tools, Pages 307-316, Barbara A. Zehnbauer, Bradley D. Freeman, Timothy G. Buchman
27 - Shock Models: Hemorrhage, Pages 317-330, Alfred Ayala, Ping Wang, Irshad H. Chaudry
28 - Scoring Systems for Trauma Research, Pages 331-346, Walter L. Biffl, Ernest E. Moore
29 - Blunt Trauma Models: Fractures, Chest Trauma, Head Injury, Soft-Tissue Trauma, and Abdominal Trauma, Pages 347-356, R. Lawrence Reed II
30 - Trauma Models for Studying the Influence of Gender and Aging, Pages 357-366, Martin G. Schwacha, Ping Wang, Irshad H. Chaudry
31 - Animal Models of Burn Injury, Pages 367-377, Daniel L. Traber, Robert E. Barrow, David N. Herndon
32 - Wound Care Models, Pages 379-391, David G. Greenhalgh, Glenn D. Warden
33 - Models of Adult Respiratory Distress Syndrome—Aspiration, Pages 393-399, H. Hank Simms
34 - Tumor Angiogenesis, Pages 401-413, Lee M. Ellis
35 - Approaches to Adoptive Immunotherapy, Pages 415-434, Harry D. Bear, Cynthia S. Chin
36 - Metastasis: Biology and Experimental Models, Pages 435-444, Russell S. Berman, Jerald J. Killion, Lee M. Ellis
37 - Cancer Genetics, Pages 445-456, Douglas W. Green, Jeffrey A. Drebin
38 - Cancer Gene Therapy, Pages 457-496, Kenneth K. Tanabe, James C. Cusack Jr.
39 - Active Immunotherapy for Cancer, Pages 497-506, Keith D. Amos, David C. Linehan, Timothy J. Eberlein
40 - Gastrointestinal Motility, Pages 507-532, Michael G. Sarr, Joseph J. Cullen, Mary F. Otterson
41 - Models of Intestinal Secretion and Absorption, Pages 533-546, Martin Riegler, Jeffrey B. Matthews
42 - Surgical Models of Inflammatory Bowel Disease, Pages 547-555, Heidi Yeh, John L. Rombeau
43 - Intestinal Regeneration and Adaptation Models, Pages 557-571, Sonia Y. Archer, Richard A. Hodin
44 - Minimally Invasive Surgery, Pages 573-582, Daniel B. Jones, Robert V. Rege
45 - Experimental Models and Endpoints for Studies of Intestinal Ischemia-Reperfusion Injury, Pages 583-597, Joseph Murphy, Richard H. Turnage
46 - Gut Barrier Failure, Pages 599-611, Justin T. Sambol, Raquel M. Forsythe, Edwin A. Deitch
47 - Developmental Studies in the Gastrointestinal Tract, Pages 613-622, George K. Gittes, Thomas S. Maldonado, Christopher A. Crisera
48 - Animal Models of Liver Failure, Pages 623-636, Jacek Rozga, Achilles A. Demetriou
49 - Portal Hypertension and Portacaval Shunt, Pages 637-701, Marshall J. Orloff
50 - Animal Models of Liver Regeneration, Pages 703-708, Jacek Rozga
51 - Animal Models for the Study of Hepatocyte Transplantation, Pages 709-719, Daniel Inderbitzin, Jacek Rozga, Achilles A. Demetriou
52 - Biliary Stone Formation, Pages 721-732, Matthew I. Goldblatt, Attila Nakeeb, Henry A. Pitt
53 - Models for the Study of Pancreatitis, Pages 733-746, Michael L. Steer
54 - Models of Endocrine Insufficiency, Pages 747-756, Thomas C. Vary
55 - Animal Models in Transplantation, Pages 757-771, I.L. Laskowski, J.B. Ames, M. Gasser, D. Whitley, N.L. Tilney
56 - Models to Study Surgical Nutrition and Metabolism, Pages 773-788, Wiley W. Souba, Douglas W. Wilmore
57 - Stable Isotopes, Pages 789-795, Robert R. Wolfe
58 - Body Composition, Pages 797-812, Lindsay D. Plank, Graham L. Hill
59 - Energetics, Pages 813-823, Danny O. Jacobs, Takeaki Matsuda
60 - Models of Protein Metabolism, Pages 825-844, Per-Olof Hasselgren, David R. Fischer, Timothy A. Pritts
61 - Membrane Transport of Nutrients, Pages 845-856, Bruce R. Stevens
62 - Models of Wound Healing in Growth Factor Studies, Pages 857-873, Alexandrina Saulis, Thomas A. Mustoe
63 - Animal Models of Sepsis and the Multiple Organ Dysfunction Syndrome, Pages 875-891, Mitchell P. Fink
64 - The Immuno-Inflammatory Response, Pages 893-908, Eileen M. Bulger, Avery B. Nathens, Ronald V. Maier
65 - Antibiotic Trials, Pages 909-919, E. Patchen Dellinger
66 - Scoring Systems for Sepsis and the Multiple Organ Dysfunction Syndrome, Pages 921-931, John C. Marshall
67 - Cytokine Biology, Pages 933-947, Rebecca M. Minter, Frank J. Wessels, Lyle L. Moldawer
68 - Biology of Nitric Oxide: Measurement, Modulation, and Models, Pages 949-969, Joy L. Collins, Yoram Vodovotz, Timothy R. Billiar
69 - Endothelial Cell and Smooth Muscle Cell Biology in Vascular Disease, Pages 971-987, Richard D. Kenagy, Alexander W. Clowes
70 - Coagulation Biology, Pages 989-1000, Daniel D. Myers Jr., Shirley K. Wrobleski, Peter K. Henke, Thomas W. Wakefield
71 - Endovascular Research: Stents, Pages 1001-1010, Darwin Eton, Kyung M. Ro, Samuel S. Ahn
72 - Noninvasive Vascular Measurements, Pages 1011-1025, Stephen R. Lauterbach, Nancy R. Macdonald, William M. Abbott
73 - Techniques to Study Microcirculation, Pages 1027-1035, David A. Spain, R. Neal Garrison
74 - Blood Substitutes in Surgery, Pages 1037-1046, Gus J. Vlahakes
75 - Research Models in Pediatric Surgery, Pages 1047-1064, Brad W. Warner
76 - Research in Fetal Surgery, Pages 1065-1079, Alexander Sasha Krupnick, N. Scott Adzick
77 - Research in Plastic Surgery, Pages 1081-1094, Gyu S. Chin, Jason A. Spector, Stephen M. Warren, Michael T. Longaker
78 - Research Methods in Neurosurgery, Pages 1095-1105, Svetlana Ivanova, Kevin J. Tracey
79 - Research in Urologic Surgery, Pages 1107-1118, Roger E. De Filippo, Anthony Atala
80 - Research in Cardiac Surgery, Pages 1119-1136, Robert M. Mentzer Jr., Caren M. Mulford, Robert D. Lasley
81 - Research in Orthopedic Surgery, Pages 1137-1200, A. Simon Turner
82 - Statistical Analysis—Specific Statistical Tests: Indications for Use, Pages 1201-1215, David T. Mauger, Gordon L. Kauffman Jr.
83 - Data Presentation: How to Write and Submit Abstracts and Papers, Pages 1217-1236, Nancy R. Ehrlich, Patricia A. Sheiner
84 - Audiovisual Communications as a Research Skill, Pages 1237-1240, Charles M. Balch
85 - Organizing and Managing Meetings and Conferences, Pages 1241-1248, Mary C. Schuerman, P. William Curreri
86 - The Management and Organization of a Surgical Research Laboratory, Pages 1249-1259, David T. Efron, Daniel Most, Adrian Barbul
87 - History and Philosophy of Surgical Research, Pages 1261-1277, Clyde F. Barker
88 - The Surgical Research Program as a Business Enterprise, Pages 1279-1286, Jeffrey H. Lawson, Robert W. Anderson
89 - Nobel Laureates in Surgery, Pages 1287-1297, Moritz M. Ziegler
90 - Surgical Education Research, Pages 1299-1307, Andreas H. Meier, Paul J. Gorman, Thomas M. Krummel
91 - Mathematical Modeling, Pages 1309-1317, Denise E. Kirschner, Timothy G. Buchman
92 - Information Resource Discovery for Surgeons: Databases and the Internet, Pages 1319-1336, Suzy Conway, Anna Getselman, Lucretia W. McClure
93 - How to Review a Manuscript, Pages 1337-1341, Ori D. Rotstein
94 - Academic Surgical Mentoring, Pages 1343-1347, Clay Cothren, Julie Heimbach, Thomas N. Robinson, Casey Calkins, Alden H. Harken
95 - Ethics and Surgical Research, Pages 1349-1360, Timothy M. Pawlik, Lisa Colletti
96 - The National Institutes of Health: Procedures and Performance, Pages 1361-1373, Scott D. Somers
97 - Measuring the Performance of Surgical Research, Pages 1375-1381, Wiley W. Souba, Douglas W. Wilmore
98 - Virtual Reality and Surgery, Pages 1383-1392, Joseph M. Rosen, Marcus K. Simpson, Charles Lucey
99 - Surgeons and Health Services Research, Pages 1393-1404, Robert S. Rhodes, Susan D. Horn
100 - From Idea to Product: Financing and Regulatory Issues in Product Development, Pages 1405-1414, Jonathan Gertler, James Garvey
Index, Pages 1415-1460