Surfactant Replacement Therapy: in Neonatal and Adult Respiratory Distress Syndrome

Front Matter....Pages I-XXII
Pulmonary Surfactant: Evolution of Functional Concepts....Pages 1-9
Front Matter....Pages 11-11
Evaluation of Pulmonary Surfactant....Pages 13-17
Some Remarks on the Use of Physico-Chemical Methods in Lung Surfactant Research....Pages 18-27
In Vivo Tests for Evaluation of Pulmonary Surfactant....Pages 28-36
Efficacy and Standardisation of SF-RI 1: A Preparation from Bovine Lung Surfactant....Pages 37-41
Comparison Between Natural and Artificial Surfactant Preparations in Premature Rabbit Fetuses....Pages 42-46
Front Matter....Pages 47-47
Respiratory Distress Syndrome: Requirements of Perinatal Diagnosis, Prevention and Treatment....Pages 49-57
Diagnosis of Surfactant Defects in Newborn, Children and Adults in the Era of Surfactant Therapy....Pages 58-65
Assessment of Surfactant Function by Measurement of the Pulmonary Clearance of Inhaled Tc-99m-DTPA....Pages 66-76
Pneumotachographic Measurements of Lung Function in Preterm Infants with Respiratory Distress Syndrome....Pages 77-87
Front Matter....Pages 89-89
Factors Affecting the Response to a Postnatal Single Dose of a Reconstituted Bovine Surfactant (Surfactant TA)....Pages 91-107
A Multicenter Randomized Trial of Surfactant Replacement with Calf Lung Surfactant Extract: Effects of Pre- and Post-Ventilatory Instillation and of Multiple Doses....Pages 108-122
The European Multicenter Trial of Surfactant Replacement in Neonatal Respiratory Distress Syndrome....Pages 123-126
Use of Surfactant in Very Low Birth Weight Infants with Severe Respiratory Distress Syndrome: Initial Experience and Problems....Pages 127-132
Surfactant Replacement with SF-RI 1 in Premature Infants with Respiratory Distress Syndrome: A Clinical Pilot Study....Pages 133-133
Ventilator Settings After Surfactant Replacement with SF-RI 1: Clinical Experiences....Pages 134-135
Human Surfactant from Amniotic Fluid in the Treatment of Respiratory Distress Syndrome....Pages 136-142
Clinical Response to Human Surfactant....Pages 143-149
Human Surfactant and Calf Lung Surfactant Extract: Moderation of Respiratory Distress in Preterm Infants by a Single Prophylactic Dose in a Randomized and Controlled Clinical Trial....Pages 150-157
Artificial Surfactant: Prophylaxis for Respiratory Distress Syndrome....Pages 158-167
Front Matter....Pages 89-89
Rapid Response of Oxygenation, Slow Response of Compliance After Liposomal Phospholipid Substitution in Respiratory Distress Syndrome....Pages 168-180
Impact of Surfactant Therapy on Bronchopulmonary Dysplasia....Pages 181-188
Alveolar Atelectasis as a Mechanism for Infantile Apnoea: A Possible Role for Exogenous Surfactant Therapy?....Pages 189-194
Changes in Pulmonary and Cerebral Blood Flow After Surfactant Treatment for Severe Respiratory Distress Syndrome....Pages 195-200
Front Matter....Pages 201-201
The Future for Surfactant Therapy of the Adult Respiratory Distress Syndrome....Pages 203-211
Surfactant Replacement in Acute Respiratory Failure: Animal Studies and First Clinical Trials....Pages 212-223
Pulmonary Surfactant Effects and Replacement in Oxygen Toxicity and Other ARDS-Type Lung Injuries....Pages 224-244
Surfactant Replacement in Respiratory Failure Induced by Aspiration of Hydrochloric Acid in Rabbits....Pages 245-257
Efficacy of Exogenous Surfactant in Experimental Aspiration Trauma....Pages 258-261
Acute Effects of an Artificial Surfactant (Exosurf) Administered as an Aerosol in Sheep with Oleic Acid-Induced Lung Injury....Pages 262-264
Discussion: What is the Surfactant of Choice for Replacement Therapy?....Pages 265-272
Front Matter....Pages 273-273
What Happens to Treatment Doses of Surfactant?....Pages 275-292
Distribution of Exogenous Surfactant in Premature Lambs: High-Frequency Oscillation Ventilation Versus Conventional Mechanical Ventilation....Pages 293-297
Immunohistochemical Study of the Distribution of Exogenous Surfactant in the Lungs of Surfactant-Deficient Rabbits Using a Monoclonal Antibody....Pages 298-300
Immunogenicity of Surfactant and Its Implications for Replacement Therapy....Pages 301-313
Surfactant Treatment of Newborn Rabbits Impedes Intrapulmonary Phagocytic Killing of Inhaled Group B Streptococci....Pages 314-318
Effect of Bovine Surfactant on Mucus Secretion from Tracheal Submucosal Glands....Pages 319-325
Front Matter....Pages 327-327
The Bronchoalveolar Surfactant System Inhibits the Cardiovascular Effects of Angiotensin II, Serotonin, and Platelet-Activating Factor....Pages 329-331
Artificial Surfactants Based on Different Hydrophobic Low-Molecular-Weight Proteins....Pages 332-337
Reconstitution of Human Surfactant Activity Using Low-Molecular-Weight Apoproteins....Pages 338-343
Front Matter....Pages 327-327
The Macromolecular Organization of Canine Lung Surfactant Protein SP 28–36: Structural Homology with the Complement Factor C1q....Pages 344-350
Two-Step Substitution of Surfactant in Fetal Minipigs....Pages 351-354
Front Matter....Pages 355-355
Regulation of Phosphatidylcholine Synthesis in Type II Alveolar Epithelial Cells....Pages 357-361
A Controlled Trial of CPD-Choline Administration in Premature Infants with Respiratory Distress Syndrome....Pages 362-368
Effects of the β 2 -Adrenoceptor-Stimulating Agent Terbutaline and Its Antagonist ICI 118.551 on Rat Lung Surfactant (Phospholipid) Metabolism....Pages 369-372
Back Matter....Pages 373-378