Sucralfate: From Basic Science to the Bedside

Front Matter....Pages i-xxiv
Pathophysiology of Peptic Ulcer Disease....Pages 1-13
Decreased Intragastric Acid Concentration as an Approach to Peptic Disease Therapy....Pages 15-23
Ulcer Healing by Strengthening of Mucosal Defense....Pages 25-34
History of the Development of Sucralfate....Pages 35-45
Chemistry of Sucralfate....Pages 47-58
Binding of Bile Acids by Sucralfate....Pages 59-70
Binding of Sucralfate to the Mucosal Surface....Pages 71-82
Stimulation of Mucus Production....Pages 83-88
Gastroduodenal Bicarbonate Secretion and its Response to Sucralfate....Pages 89-101
Effect of Sucrose Octasulfate on Isolated Gastric Cells....Pages 103-109
Effect on Gastric Surfactant....Pages 111-126
Stimulation of Mucosal Prostaglandins by Sucralfate....Pages 127-132
Sucralfate and Helicobacter pylori ....Pages 133-140
Sucralfate and Cell Proliferation....Pages 141-149
Vascular Factors....Pages 151-162
Sucralfate....Pages 163-173
Effects of Sucralfate on Growth Factor Availability....Pages 175-189
Duodenal Ulcer Therapy, “Acid Rebound,” and Early Relapse....Pages 191-196
Effect of Sucralfate on Experimental Ulcers....Pages 197-207
Effect on Experimental Esophageal Injury....Pages 209-214
Safety of Sucralfate....Pages 215-224
Sucralfate Drug Interaction Studies....Pages 225-238
Therapy of Gastric Ulcer Disease....Pages 239-247
Therapy of Active Duodenal Ulcers....Pages 249-255
Prevention of Ulcer Recurrence....Pages 257-270
Therapy of Esophagitis....Pages 271-276
Sucralfate for NSAID-Induced Gastroduodenal Lesions....Pages 277-288
Sucralfate for Prevention of Acute Gastrointestinal Bleeding....Pages 289-301
Prevention of Respiratory Tract Infections with Sucralfate in Ventilated ICU Patients....Pages 303-315
Sucralfate in Nonulcer Dyspepsia, Gastritis, and Duodenitis....Pages 317-322
Use of Sucralfate in Variceal Sclerotherapy-Induced Ulcerations....Pages 323-331
Future Research into the Mechanisms of Action of Sucralfate....Pages 333-337
Future Clinical Development of Sucralfate....Pages 339-349
Back Matter....Pages 351-366