Substance P and Neurokinins: Proceedings of “Substance P and Neurokinins—Montréal ’86” A Satellite Symposium of the XXX International Congress of The International Union of Physiological Sciences

Front Matter....Pages i-xviii
Substance P and Neurokinins....Pages 1-2
Cloning and Expression of Rat and Human Tachykinin Genes....Pages 3-4
Structure, Expression and Regulation of the Rat Preprotachykinin I Gene....Pages 5-7
Striatonigral Tachykinin Biosynthesis I. Effect of the Dopamine Antagonist Haloperidol....Pages 8-11
Thyroid Hormone Regulates Tachykinin Gene Expression in Rat Anterior Pituitary....Pages 12-14
Phylogeny of the Tachykinins....Pages 15-17
Metabolism of Tachykinins by Cell-Surface Peptidases....Pages 18-20
Structure and Post-Translational Processing of the Preprotachykinins....Pages 21-23
Substance P Content in and Capsaicin-Evoked Release from Dissociated Cultures of Rat Nodose Ganglion (Vagal Sensory) Neurons....Pages 24-26
Biosynthesis of Substance P and Neurokinin A in the Enteric Nervous System....Pages 27-29
Striatonigral Tachykinin Biosynthesis....Pages 30-32
Substance P Precursor Studies in Carcinoid Tumours....Pages 33-36
Chronic Neuroleptic Administration Reduces Striatal Substance P mRNA and the Localization of Substance P mRNA in Rat Brain by In Situ Hybridization....Pages 37-39
Multiple Receptors and Binding Sites for Tachykinins....Pages 40-43
Multiple Tachykinin Binding Sites in Rat Brain and Peripheral Tissues....Pages 44-46
 3 H-Neurokinin Band 125 I-Bolton Hunter Eledoisin Label Identical Tachykinin Binding Sites in the Rat Brain....Pages 47-49
Characterization of Tachykinin Receptor Subtypes Using Selective Ligands....Pages 50-51
Characterization of Binding of [ 125 I]Iodohistidyl 1 -Substance K to Tachykinin K-Sites in Hamster Bladder....Pages 52-52
Endothelial-Dependent Binding of [ 125 I]-Bolton-Hunter Substance P in Blood Vessels....Pages 53-55
Tachykinin-Induced Phosphatidylinositol Turnover in Hamster Urinary Bladder....Pages 56-59
Conformationally Restricted Analogues of Substance P....Pages 60-62
Toward the Bioactive Conformation of Tachykinins?....Pages 63-65
Evidence for the Zipper Model in Tachykinin Receptor Binding....Pages 66-68
Effects of Substance P on the Binding of Ligands to Nicotinic Acetylcholine Receptors on Torpedo Electroplaque Membranes....Pages 69-71
Interaction of Analgesic Capsaicin Analogs with Substance P Receptors....Pages 72-74
Tachykinins and Phosphatidyl Inositol Turnover in Rat Brain....Pages 75-77
Tyr 8 -Substance P Binding Study on a Plasma Membrane from Dog Ileum Smooth Muscle....Pages 78-79
Multiple Tachykinin Binding Sites in Hamster, Guinea-Pig and Rat Bladder....Pages 80-80
Tachykinin P-type Binding Sites in Dog Kidney....Pages 81-83
Substance P Binding Sites in Guinea-Pig Enteric Ganglia....Pages 84-86
Autoradiographic Localization of Substance P Binding Sites in Guinea-Pig Respiratory Tract....Pages 87-89
[ 125 I]-Bolton Hunter Substance P Specific Binding Sites on Cortical Astrocytes from New Born Mouse in Primary Culture....Pages 90-92
Autoradiographic Distribution of Binding Sites for Iodinated Tachykinins in the Rat Central Nervous System....Pages 93-95
Neurokinin Receptors in Human Brain....Pages 96-98
Receptors for Neurokinins in Peripheral Organs....Pages 99-107
Substance-P-Induced Desensitization in Canine Cephalic Arteries is not Mimicked by Substance K, Physalaemin, or Kassinin....Pages 108-110
Multiple Neurokinin Receptors in the Rat Lower Urinary Tract....Pages 111-113
Structure-Activity Relationships of Neurokinin A and B....Pages 114-115
Tachykinin Antagonists with Cyclic Structures....Pages 116-118
Electrical and Mechanical Responses of Vascular Muscle to Tachykinins....Pages 119-121
[D-Pro 2 ,D-Trp 6,8 ,Nle 10 ]-Neurokinin B: Pharmacological Profile of a Novel Neurokinin Antagonist....Pages 122-124
Isolated Arterial and Venous Vessels as Selective Pharmacological Preparations for Neurokinins....Pages 125-128
Neurokinin Fragments and Analogues as Selective Activators of Receptors....Pages 129-131
Mammalian Neurokinins: Structure-Activity Study of the N- and C- Terminals....Pages 132-134
Neurokinin Receptor Mechanisms in Smooth Muscle....Pages 135-137
Neurokinin Receptors in Guinea-Pig Intestinal Muscle....Pages 138-140
Multiple Neurokinin Receptors in the Guinea Pig Ileum....Pages 141-143
Synthesis and Biological Activity of Agonists for the Neuronal Tachykinin Receptor in Guinea Pig Ileum....Pages 144-145
Tachykinin Activation of Muscarinic Inhibition in Canine Small Intestine is Substance P in Nature....Pages 146-148
Evidence for Three Distinct Peripheral Neurokinin Receptors Using a Putative Neurokinin B Antagonist....Pages 149-151
Identification and Localization of Substance P Receptors on the Endothelium of the Pig Coronary Artery....Pages 152-157
Activity of the C-Terminal Part in Tachykinins on Guinea Pig Ileum and Trachea Preparations....Pages 158-160
Relative Vasodilatory Potencies of Substance P, Deca-Substance P and Nona-Substance P in the Canine Forelimb....Pages 161-163
Hemodynamic Actions of Substance P in Anesthetized Rats....Pages 164-165
The Effect of Substance P Antiserum on Responses of Guinea-Pig Isolated Ileum to Substance P and Acetylcholine....Pages 166-167
Antibodies as Tools for Studying Tachykinins and Their Receptors....Pages 168-170
Characterization of Spinal Actions of Ten Substance P Analogs....Pages 171-175
Substance P Antagonists and Analgesia: Do They or Don’t They?....Pages 176-178
Substance P in Human Spermatozoa and Modulation of Sperm Motility by Substance P and Its Antagonists....Pages 179-181
Effector Roles of Substance P in Peripheral Branches of Sensory Neurons....Pages 182-186
Tachykinins and Gastrointestinal Propulsion in the Rat In Vivo....Pages 187-188
Substance P Effects on the Long-Term Regulation of Adrenal Catecholamine Levels....Pages 189-191
Effects of Substance P and Calcitonin-Gene-Related Peptide on Skeletal Muscle Microcirculation....Pages 192-194
Substance P Effect on the Secretory Process in Rat Parotid Gland....Pages 195-196
Effects of Substance P on Blood Flow of the Dental Pulp in Dogs....Pages 197-199
Influence of Anesthesia and Atropine on Plasma Extravasation Induced by Mammalian Tachykinins in the Rat....Pages 200-202
Tachykinin-Induced Plasma Extravasation in Rat Skin is Mediated Through the SP-P Receptor....Pages 203-204
Peptides as Promotors of Paracellular Permeability: A Novel Role For Tachykinins?....Pages 205-207
Release of Substance P from Isolated Guinea Pig Heart....Pages 208-209
Effects of Tachykinins on the Rat Stomach In Vivo and In Vitro....Pages 210-211
Endoluminal Substance P is Released by a Meal....Pages 212-213
Effect of Substance P and Neurokinins on the Endocrine Secretion of the Pancreas and Stomach....Pages 214-216
Development of the Substance-P-Like Immunoreactive Innervation of the Mesenteric Vascular Bed in Normotensive and Hypertensive Rats....Pages 217-219
Increase of Plasma Substance P- and Neurokinin A-Like Immunoreactivity During Carcinoid Flushing....Pages 220-222
HPLC and Immunohistochemical Characterization of Substance P-Like Immunoreactivity in a Human Pheochromocytoma....Pages 223-225
Role of Capsaicin-Sensitive Primary Afferent Nerves in the Neuroendocrine Copulation Reflex....Pages 226-228
Substance K-, Substance P-, and Calcitonin Gene-Related Peptide-Immunoreactive Nerves in Female Reproductive Organs....Pages 229-231
Substance P- and Somatostatin-Like Immunoreactivity in Maternal and in Umbilical Cord Plasma and in Amniotic Fluid....Pages 232-234
Effects of Spantide on Reflexes of Slow Time Courses in Isolated Rat Spinal Cord....Pages 235-238
A Depressant Action of Substance P on Spinal Nociceptive Neurons in the Rat and Cat....Pages 239-240
Physalaemin, Substance P and Neurokinin A Potentiate Purine-Induced Depression of Spinal Dorsal Horn Neurones in the Cat....Pages 241-243
Multiple Tachykinins and Calcitonin Gene-Related Peptide (CGRP) in Capsaicin-Sensitive Nerves of Sympathetic Ganglia....Pages 244-245
Intrathecal Substance P Produces a Long-Term Inhibition of the Spinal Analgesic Effect of Noradrenaline....Pages 246-248
Pharmacological Modulation of Antidromic Vasodilatation Measured by Laser Doppler Flowmetry....Pages 249-250
Capsaicin Sensitive Afferent Neurons Involved in Neuroendocrine Regulations....Pages 251-253
Sensory C Fiber Mediate Mucociliary Responses to Airway Irritants....Pages 254-256
Substance P Modulates Cholinergic Regulation of the Nicotinic Acetylcholine Receptor of PC12 Cells....Pages 257-259
Evidence of ACTH-Adrenal and Chronic Stress-Induced Down Regulation of Substance P in the Sensory Vagus Nerve....Pages 260-262
Substance P and Hypoxic Excitation of the Carotid Body....Pages 263-265
Immunochemical Studies on Substance P Release from Muscularis Mucosa of Opossum Esophagus....Pages 266-269
Substance P-Immunoreactive Fibers in the Trigeminal Sensory Nuclei of Pit Vipers, Trimeresurus Flavoviridis ....Pages 270-272
Miotic Effect of Echothiophate Iodide in Humans: Possible Role of Iris Substance P....Pages 273-275
The Effects of Neurokinin A and Calcitonin Gene-Related Peptide on Mucociliary Activity....Pages 276-278
Neurokinin A Excites Nociceptive and Non-Nociceptive Dorsal Horn Neurones in the Cat Spinal Cord....Pages 279-281
Modality Specific Analgesia Produced by Intrathecal Anti-Substance P Antibody....Pages 282-284
A Quantitative Study of Substance P and Cholecystokinin Coexistence in Primary Afferent Axonal Varicosities in the Rat Spinal Cord....Pages 285-287
Sciatic Nerve Stimulation and Substance P Release from Posterior Pituitary Lobe (PPL) in Rats....Pages 288-290
Neurokinin A as a Transmitter of Primary Afferents Involved in Thermal Nociception....Pages 291-293
Reflections on Substance P and Some Related Peptides....Pages 294-296
Regional Distribution of Neurokinin A and Substance P in the Rat Central Nervous System....Pages 297-299
Regulation of Substance P Immunoreactivity in GABA Neurons of Monkey Visual Cortex by Sensory Deprivation....Pages 300-301
Interactions Between Substance P and Nicotinic Acetylcholine Receptors in Pain Control Mechanisms in the Rat....Pages 302-304
Central Modulation of Blood Pressure by N- and C-Terminal Fragments of Substance P....Pages 305-307
Effects of Tachykinins on Dopamine Release in the Striatum: In Vitro and In Vivo Studies....Pages 308-310
Immunocytochemical Localization of Substance P-Like Immunoreactivity in the Human Hypothalamus....Pages 311-312
Substance P and Somatostatin-Like Immunoreactivities in Synaptic Glomeruli of the Rat Substantia Gelatinosa, as Revealed by Bi-Specific Monoclonal Antibodies....Pages 313-317
A Sex Difference in the Pattern of Substance P-Like Immunoreactvity in the Bed Nucleus of the Stria Terminalis....Pages 318-320
Suppression of Noradrenaline-Induced Ovulation by Administration of Substance P into the Third Cerebral Ventricle in Pseudo-Pregnant Rats....Pages 321-323
Spinal Actions of Substance P on Cardiovascular Responses in the Rat....Pages 324-327
Evidence for at Least Two Tachykinin Receptor Subtypes in the Mammalian Spinal Cord....Pages 328-330
Spinal and Supraspinal Substance P Antinociception: Synergistic Interaction....Pages 331-333
Substance P Empty Neuron: A Conceptualization of Organic and Functional Deafferentation Syndromes....Pages 334-336
Excitatory Effects of Substance P and Related Peptides on Oxytocin-Sensitive Non-Pyramidal Neurones in Rat Hippocampus....Pages 337-339
Electrophysiological Correlates of Bradykinin and Other Neuropeptides in Developing Rat Cerebral Cortex....Pages 340-343
Effects of an Amino-Terminal Fragment of Substance P on Brain Dopamine and Serotonin Metabolism....Pages 344-346
Effect of Carbamazepine on Substance P Content in the Rat Brain....Pages 347-349
Release of Substance P, Acetylcholine and Methionine Enkephalin from Mouse Cerebral Slices: Effects of Nicotine....Pages 350-352
Different Functional Roles for Substance P and Dynorphin in the Striato-Nigral Pathways of the Rat....Pages 353-355
Striato-Nigral Tachykinin Neurons and Influence from Striatal Dopamine and GABA....Pages 356-358
Substance P, Thyrotropin-Releasing Hormone, and Serotonin Neurons Sprout in Cervical Ventral Horn of the Wobbler Mouse, a Model for Motoneuron Disease....Pages 359-362
Intra-Raphe Substance P5–11 but Not Muscimol-Induced Hyperactivity is Mediated by Serotonin Neurons....Pages 363-365
Heterogeneity of Central and Peripheral Tachykinin Binding Sites....Pages 366-371
Research on Tachykinins: Clinical Trends....Pages 372-379
A Network of Defense....Pages 380-387
Back Matter....Pages 389-391