Studies on Renal Disorders

Front Matter....Pages i-xviii
Front Matter....Pages 1-1
Oxidative Stress Injury in Glomerular Mesangium....Pages 3-23
Transition Metals and Other Forms of Oxidative Protein Damage in Renal Disease....Pages 25-50
Cyclooxygenase in the Kidney and Oxidative Stress....Pages 51-69
Renin-Angiotensin System in the Kidney and Oxidative Stress: Local Renin-Angiotensin-Aldosterone System and NADPH Oxidase-Dependent Oxidative Stress in the Kidney....Pages 71-91
Thiamine in Diabetic Renal Disease: Dietary Insufficiency, Renal Washout, Antistress Gene Response, Therapeutic Supplements, Risk Predictor, and Link to Genetic Susceptibility....Pages 93-104
Novel Members of the Globin Family and Their Function Against Oxidative Stress....Pages 105-117
Front Matter....Pages 119-119
Hypertension....Pages 121-142
Uric Acid and Oxidative Stress....Pages 143-159
Reactive Oxygen and Nitrogen Species, Oxidative and Nitrosative Stress, and Their Role in the Pathogenesis of Acute Kidney Injury....Pages 161-177
Oxidative Stress in the Kidney: Proximal Tubule Disorders....Pages 179-203
Iron Metabolism and Oxidative Stress....Pages 205-228
Hypoxia, Oxidative Stress, and the Pathophysiology of Contrast-Media-Induced Nephropathy....Pages 229-256
Cardiovascular Complications in Renal Failure: Implications of Advanced Glycation End Products and Their Receptor RAGE....Pages 257-292
Infection and the Kidney....Pages 293-304
Oxidative/Carbonyl Stress in the Renal Circulation and Cardiovascular Renal Injury....Pages 305-320
Front Matter....Pages 321-321
The Renin Angiotensin System....Pages 323-335
Oxidative Stress in Kidney Injury: Peroxisome Proliferator-Activated Receptor-γ Agonists Are in Control....Pages 337-350
Current Therapy Targeting Oxidative Stress: Statin....Pages 351-366
 N -Acetylcysteine in Kidney Disease....Pages 367-388
Advanced Glycation End Products Inhibitor....Pages 389-406
Front Matter....Pages 407-407
Involvement of Hypoxia-Inducible Factor 1 in Physiological and Pathological Responses to Continuous and Intermittent Hypoxia: Role of Reactive Oxygen Species....Pages 409-418
Regulation of Oxygen Homeostasis by Prolyl Hydroxylase Domains....Pages 419-436
Oxygen-Dependent Regulation of Erythropoiesis....Pages 437-463
Intricate Link between Hypoxia and Oxidative Stress in Chronic Kidney Disease....Pages 465-477
RNA Interference and the Regulation of Renal Gene Expression in Hypoxia....Pages 479-496
Front Matter....Pages 497-497
Cardio-Renal Connection: The Role of Hypoxia and Oxidative Stress....Pages 499-533
Hypoxia-Inducible Factors in Acute Kidney Injury: From Pathophysiology to a Novel Approach of Organ Protection....Pages 535-544
Hypoxia in Chronic Kidney Disease: The Final Common Pathway to End Stage Renal Disease....Pages 545-557
Oxidative Stress and Hypoxia in the Pathogenesis of Diabetic Nephropathy....Pages 559-586
Estimation of Kidney Oxygenation by Blood Oxygenation Level Dependent Magnetic Resonance Imaging....Pages 587-609
Anemia and Progression of Chronic Kidney Disease....Pages 611-630
Front Matter....Pages 631-631
Novel Therapeutic Approaches Against Oxidative Stress and Hypoxia, Targeting Intracellular Sensor Molecules for Oxygen and Oxidative Stress....Pages 633-656
Endoplasmic Reticulum Stress as a Target of Therapy Against Oxidative Stress and Hypoxia....Pages 657-672
Stem Cell Therapy Against Oxidative Stress and Hypoxia....Pages 673-687
Back Matter....Pages 689-783