Structure-activity relationships of the cannabinoids

Table of Contents......Page 8
Preface......Page 6
Introduction......Page 10
Structure-Activity Relationships in Cannabinoids: An Overview......Page 12
Stereochemical Requirements for Cannabimimetic Activity......Page 24
Structure-Activity Relationships of Tricyclic and Nonclassical Bicyclic Cannabinoids......Page 40
Structure-Anticonvulsant Activity Relationships of Cannabidiol Analogs......Page 57
Anticonvulsant and Neurotoxic Effects of Tetrahydrocannabinol Stereoisomers......Page 68
Different Cannabinoids Exhibit Different Electrophysiological Properties......Page 76
Molecular Determinants for Cannabinoid Activity: Refinement of a Molecular Reactivity Template......Page 91
Different Cannabinoids Exhibit Different Pharmacological and Toxicological Properties......Page 105
Pharmacological Evaluation of Agonistic and Antagonistic inoids Activity of Cannab......Page 117
Interactions of Cannabinoids With Membranes. The Role of Cannabinoid Stereochemistry and Absolute Configuration and the Orientation of Delta-9-THC in the Membrane Bilayer......Page 132
The High Affinity Cannabinoid Binding Site in Brain: Regulation by Guanine Nucleotides and Isolation of an Endogenous Inhibitor......Page 143
Regulation of Adenylate Cyclase in a Cultured Neuronal Cell Line by Marijuana Constituents, Metabolites of Delta-9-tetrahydrocannabinol, and Synthetic Analogs Having Psychoactivity......Page 157
Inhibitory and Stimulatory Effects of Cannabinoids on Eicosanoid Synthesis......Page 167
Pharmacokinetics and Disposition of Cannabinoids......Page 182
Drug Abuse in India: Progress in Research......Page 198
The Medicinal Chemistry of Cannabinoids: An Overview......Page 213
List of NIDA Research Monographs......Page 220