Structure, Function, and Genetics of Ribosomes

Front Matter....Pages i-xxii
Structure of Ribosomes....Pages 1-27
Immuno Electron Microscopy on Escherichia coli Ribosomes....Pages 28-46
Ribosome Structure, Function, and Evolution: Mapping Ribosomal RNA, Proteins, and Functional Sites in Three Dimensions....Pages 47-67
Structure of Ribosomes and Their Components by Advanced Techniques of Electron Microscopy and Computer Image Analysis....Pages 68-86
A 19 Protein Map of the 30S Ribosomal Subunit of Escherichia coli ....Pages 87-100
Neutron-Scattering Analysis of Structural and Functional Aspects of the Ribosome: The Strategy of the Glassy Ribosome....Pages 101-111
Studies on Crystals of Intact Bacterial Ribosomal Particles....Pages 112-127
Self-Organization of Ribosomal RNA....Pages 128-142
Studies on the Structure and Function of Ribosomal RNA....Pages 143-163
Comparative Structural and Functional Studies on Small Ribosomal RNAs....Pages 164-183
RNA Structure and RNA-Protein Neighborhoods in the Ribosome....Pages 184-202
RNA Structure in Solution and on the 30S Ribosomal Subunit....Pages 203-216
The Folding of RNA in the 30S Subunit of Escherichia coli Ribosomes....Pages 217-232
Probing Ribosomal Structure and Function....Pages 233-252
How Do Protein L18 and 5S RNA Interact?....Pages 253-269
Structure and Interactions of Ribosomal Components and Ligands....Pages 270-285
Protein Topography of Ribosomal Functional Domains: Effects of Monoclonal Antibodies to Different Epitopes in Escherichia coli Protein L7/L12 on Ribosome Function and Structure....Pages 286-308
On the Structure, Function, and Dynamics of L7/L12 from Escherichia coli Ribosomes....Pages 309-325
Ribosomal Proteins: Their Structure and Evolution....Pages 326-361
Photoaffinity Labeling of Escherichia coli Ribosomes: New Approaches and Results....Pages 362-378
Structural Studies of the Factor Binding Domain....Pages 379-390
Studies of the Structure of Eukaryotic (Mammalian) Ribosomes....Pages 391-411
Structural and Functional Aspects of the N 6 , N 6 Dimethyladenosines in 16S Ribosomal RNA....Pages 412-424
Structural Dynamics of the Translating Ribosome....Pages 425-437
Conformational Change of 50S Ribosomes during Protein Synthesis....Pages 438-453
Three tRNA Binding Sites Involved in the Ribosomal Elongation Cycle....Pages 454-472
Structural and Functional Interactions of the tRNA-Ribosome Complex....Pages 473-494
The Movement of tRNA through Ribosomes during Peptide Elongation: The Displacement Reaction Model....Pages 495-508
Isomers of Aminoacyl- and Peptidyl-tRNA in the Peptidyl Transferase Reaction....Pages 509-522
Mechanism of Ribosomal Translocation....Pages 523-540
The Aminoacyl-tRNA·Elongation Factor Tu·GTP Ternary Complex and Its Role in Aminoacyl-tRNA Selection at the Ribosome....Pages 541-555
Stereochemical Analysis of Ribosomal Transpeptidation, Translocation, and Nascent Peptide Folding....Pages 556-572
Ribosomal Proteins Tune Rate and Accuracy in Translation....Pages 573-585
Involvement of Specific Portions of Ribosomal RNA in Defined Ribosomal Functions: A Study Utilizing Antibiotics....Pages 586-604
Inhibitors of Protein Synthesis as Phylogenetic Markers....Pages 605-620
Role of the Initiation Factors in Escherichia coli Translational Initiation....Pages 621-641
Arrangement of Eukaryotic Initiation Factor 3 and Messenger RNA within Preinitiation Complexes....Pages 642-657
Novel Functions of EF-Tu during Polypeptide Synthesis and tuf Gene Expression....Pages 658-671
Elongation Factor Tu Mutants and Site-Directed Mutagenesis of tufA ....Pages 672-685
Site-Directed Mutagenesis of Escherichia coli Ribosomal RNA....Pages 686-698
Structure and Expression of Ribosomal Protein Genes in Yeast....Pages 699-718
The Ribosomal Genes of Yeast and Their Regulation....Pages 719-732
Mutant Studies on the Prokaryotic Ribosome....Pages 733-748
Regulation of the Escherichia coli L10 Operon....Pages 749-765
Control of Ribosome Synthesis in Escherichia coli ....Pages 766-788
Back Matter....Pages 789-810