Strategies of Immune Regulation

Content: 
Indise Front Cover, Page ii
Front Matter, Page iii
Copyright, Page iv
CONTRIBUTORS, Pages xiii-xvii
PREFACE, Page xix, Eli E. Sercarz, Alastair J. Cunningham
CYBERNETICS AND THE IMMUNE SYSTEM, Pages 3-15, George I. Bell
THE BIOLOGICAL SIGNIFICANCE OF CELLULAR REGULATION, Pages 17-25, Peter A. Bretscher
SELF-TOLERANCE, OR WHY THE IMMUNE SYSTEM IS SO HIGHLY REGULATED, Pages 27-41, Alastair J. Cunningham
IMMUNOREGULATION: A FUTURISTIC REVIEW, Pages 43-62, Richard K. Gershon, Harvey Cantor
IMMUNOREGULATION BY T LYMPHOCYTES, Pages 63-76, J.F.A.P. Miller
CELL-CELL INTERACTIONS IN THE ESTABLISHMENT AND MAINTENANCE OF LYMPHOID TISSUE ARCHITECTURE, Pages 77-94, I.L. Weissman, E.C. Butcher, R.V. Rouse, R.G. Scollay
THE SIGNIFICANCE OF GENETIC CONTROL OF SPECIFIC T CELL IMMUNITY BY THE MAJOR HISTOCOMPATIBILITY COMPLEX, Pages 95-102, Baruj Benacerraf
VIRUS-HOST INTERACTIONS: A TELEOLOGICAL LOOK AT MHC RESTRICTION, Pages 103-120, Peter C. Doherty
MHC MOLECULES AS GUIDES FOR T LYMPHOCYTE PARALLEL SETS, Pages 121-133, N.A. Mitchison
ROLE OF MHC GENE PRODUCTS IN THE REGULATION OF CELLULAR INTERACTIONS, Pages 135-148, William E. Paul
IMMUNE RESPONSIVENESS AND POLYMORPHISM OF THE MAJOR HISTOCOMPATIBILITY COMPLEX: AN INTERPRETATION, Pages 149-156, Edward K. Wakeland, Joseph H. Nadeau
REGULATION OF ANTIBODY RESPONSES, Pages 157-177, Leonore A. Herzenberg, Samuel J. Black, Leonard A. Herzenberg
IDIOTYPIC CONTROL: THE EXPRESSION OF IDIOTYPES AND ITS REGULATION, Pages 179-198, Charles A. Janeway Jr.
THE X-Y-Z SCHEME OF IMMUNOCYTE MATURATION: I. PERTURBATIONS IN THE GROUND STATE INDUCED BY ANTIGEN, Pages 199-210, Eli E. Sercarz
REGULATION BY ANTIBODY FEEDBACK AND OTHER NONACTIVE SITE CONTROL, Pages 211-223, N.R.StC. Sinclair
INTRODUCTION TO ORGANIZATION OF Ig GENES, Page 227, N.R.StC. Sinclair
DO MINIGENES CODE FOR ALL FRAMEWORK SEGMENTS OF IMMUNOGLOBULIN CHAINS, Pages 229-231, Elvin A. Kabat, Tai Te Wu, Howard Bilofsky
ONE FROM MANY: IMMUNOGLOBULIN V REGIONS ARE THE PRODUCTS OF INTERACTING GENES, Pages 233-235, J. Donald Capra, Thomas J. Kindt
GENERATION OF ANTIBODY DIVERSITY: A PROPOSAL FROM CURRENT DATA, Pages 237-239, Nobumichi Hozumi
V/C REARRANGEMENT AND THE MOLECULAR BASIS OF ALLELIC EXCLUSION, Pages 241-242, B. Mach
A VIEW OF THE CURRENT STATUS OF POSSIBLE SOMATIC VARIATION OF IMMUNOGLOBULIN GENES, Pages 243-245, T.H. Rabbitts
ORIGIN OF ANTIBODY DIVERSITY AND THE NUMBER OF V GENES, Pages 247-248, B. Mach
INTRODUCTION TO ANTIBODY DIVERSITY AND THE DEVELOPMENT OF THE IMMUNE REPERTOIRE, Page 249, B. Mach
THE NEED FOR RAPID, RANDOM SOMATIC VARIATION IN GOD, Pages 251-252, A.J. Cunningham
LYMPHOCYTE DIFFERENTIATION: A MODEL OF “PERMISSIVENESS” FOR V-C GENE TRANSPOSITION AND THE CONTINUOUS GENERATION OF NEW Ig SPECIFICITIES, Pages 253-256, B. Mach
THE ROLE OF GERM LINE GENES AND LIMITED SOMATIC MUTATION IN THE DEVELOPMENT OF THE IMMUNE REPERTOIRE, Pages 257-260, Alan Williamson
WHERE DOES Ig DIVERSITY ARISE?, Pages 261-262, David W. Talmage
AT WHAT B CELL DEVELOPMENTAL STAGE DOES CLONAL COMMITMENT OCCUR, Pages 263-265, G.J.V. Nossal
THE NEONATAL ANTIBODY SPECIFICITY REPERTOIRE AND ITS DIVERSIFICATION, Pages 267-270, S. Marshall-Clarke, J.H.L. Playfair
UNANSWERED QUESTIONS ABOUT THE B AND T CELL REPERTOIRES, Page 271, Bonnie Blomberg
IS A UNIQUE T CELL REPERTOIRE GENERATED IN THE THYMUS?, Pages 273-276, Ron Schwartz
INTRODUCTION TO MHC RESTRICTION: CYTOTOXIC AND HELPER CELLS, Page 277
CYTOTOXIC T CELLS, Pages 279-281, P.C. Doherty
WHAT ABOUT MHC RESTRICTED T CELLS?, Pages 283-285, Rolf M. Zinkernagel
MHC AND OTHER “RESTRICTIONS” MAY BE A SIMPLE RESULT OF ANTIGEN PRIMING EXPERIENCE, Pages 287-290, A.J. Cunningham
ARE THERE DECISIVE EXPERIMENTS DISTINGUISHING ALTERED SELF AND DUAL RECOGNITION?, Page 291, David W. Talmage
T CELL RECOGNITION OF ANTIGEN IN THE CONTEXT OF H-2 ALLOGENEIC DETERMINANTS OR ANTIGEN H-2 ALLOSPECIFIC RECOGNITION, Pages 293-298, James Forman, J. Wayne Streilein
CLONAL DOMINANCE AS A MECHANISM TO ACCOUNT FOR THE FACT THAT RESTRICTIONS APPEAR TO BE IMPOSED ON CYTOTOXIC T LYMPHOCYTES BY THE THYMUS, Pages 299-304, Linda M. Pilarski
T CELL RECOGNITION: A DIFFICULTY WITH THE TWO-RECEPTOR MODEL, Pages 305-307, Jonathan Sprent
INTRODUCTION TO MHC RESTRICTION: MECHANISMS INVOLVED IN Ir GENE ACTION, Page 309
IR GENES AND I REGION RESTRICTION, Pages 311-313, Philippa Marrack, John W. Kappler
MACROPHAGE INTERACTIONS WITH T CELL SUBSETS IN ANTIBODY RESPONSES, Pages 315-317, Carl W. Pierce, Judith A. Kapp
HYPOTHESIS ON MHC CONTROL, Pages 319-321, T. Matsunaga, E. Simpson
Ia ANTIGEN STRUCTURE AND ITS RELEVANCE TO I REGION FUNCTIONS, Pages 323-326, Patricia P. Jones
THE MHC INFLUENCE ON T CELL RECEPTOR EXPRESSION, Pages 327-328, Peter H. Krammer
REGULATION OF B CELL ACTIVATION BY ALLOGENEIC EFFECT FACTOR (AEF), Pages 329-330, Terry Delovitch
INTRODUCTION TO MHC RESTRICTION: THE MACROPHAGE-MEDIATED PERCEPTION OF ANTIGEN, Page 331
EARLY EVENTS AFTER CONTACT WITH FOREIGN ANTIGENS, Pages 333-336, J.F.A.P. Miller
HOW DO THYMIC H-2 DETERMINANTS CONTROL T CELL DEVELOPMENT AND WHAT IS THE SIGNIFICANCE OF ALLOREACTIVITY, Pages 337-340, Jonathan Sprent
HIGHLY SELECTIVE ANTIGEN PROCESSING UNDER THE INFLUENCE OF MHC MOLECULES CAN CONTROL RESPONSIVENESS TO PROTEIN ANTIGENS, Pages 341-343, Alexander Miller
THE ROLE OF SOLUBLE MEDIATORS IN T HELPER CELL INDUCTION, Pages 345-347, Peter Erb
INTRODUCTION TO LYMPHOCYTE INTERACTIONS AND REGULATORY TARGETS, Page 349
INTEGRATION OF SIGNALS IN THE IMMUNE RESPONSE, Pages 351-352, Marc Feldmann, Peter Erb, Sirkka Kontiainen
A MINIMAL MODEL OF T CELL-MEDIATED REGULATION OF THE ANTIBODY RESPONSE, Pages 353-357, Tomio Tada, Ko Okumura, Masaru Taniguchi
THE CONCEPT OF “PROTECTED” HELP IN Ir GENE CONTROL, Pages 359-360, Eli E. Sercarz
SUPPRESSION OF T CELLS AT DIFFERENT DEVELOPMENTAL STAGES, Pages 361-362, R.M. Gorczynski
ANTIGEN-SPECIFIC SOLUBLE SUPPRESSOR FACTOR (S), Pages 363-365, Julia Levy, Doug Kilburn
REQUIREMENT FOR MACROPHAGES IN SUPPRESSIVE INDUCTION BY T SUPPRESSOR FACTORS, Pages 367-368, Wlodzimierz Ptak
CELL INTERACTIONS EARLY IN IMMUNE INDUCTION, Pages 369-372, F. Paraskevas
DIRECT ACTION OF SUPPRESSOR CELLS ON A B CELL HYBRIDOMA, Pages 373-374, A. Cooke, S. Marshall-Clarke
INTRODUCTION TO LYMPHOCYTE INTERACTIONS: CELL CONTACT AND SOLUBLE MEDIATORS, Page 375
THE BALANCE BETWEEN HELPER AND SUPPRESSOR FACTORS, Page 377, Alfred D. Steinberg
SOLUBLE EFFECTORS, MEDIATORS, AND FACTORS AND THEIR MECHANISMS OF ACTION, Pages 379-382, John W. Kappler, Philippa Marrack
CELL CONTACT IS NECESSARY FOR COOPERATION BETWEEN T AND B MEMORY CELLS, Pages 383-385, Herman Waldmann
Fc RECEPTORS AND Fc-MEDIATED REGULATION, Pages 387-388, N.StC. Sinclair
SPECIFIC AND NONSPECIFIC SMALL MOLECULAR WEIGHT SUPPRESSIVE FACTORS, Pages 389-391, F. Paraskevas
ON THE NATURE OF ANTIGEN-SPECIFIC T CELL FACTORS, Pages 393-394, Marc Feldmann, Sirkka Kontiainen
ON THE RELATIONSHIP BETWEEN T CELL MEMBRANE RECEPTORS FOR ANTIGEN AND ANTIGEN-SPECIFIC T CELL FACTORS, Pages 395-397, Robert E. Cone
INTRODUCTION TO ROLE OF THE Ig RECEPTOR IN TRIGGERING, Page 399
ON THE “INTELLIGENCE” OF ANTIGEN-SPECIFIC RECEPTORS FROM A NETWORK POINT OF VIEW, Pages 401-403, Geoffrey W. Hoffmann
ARE IDIOTYPIC INTERACTIONS SYMMETRICAL?, Pages 405-408, R.B. Taylor
TRIGGERING AND TOLERANCE, Pages 409-411, Göran Möller
B CELL-ANTIGEN INTERACTIONS, Pages 413-416, John W. Schrader
THE SECRET LIFE OF THE ANTIGEN-BINDING CELL, Pages 417-420, R. Ashman
INTRODUCTION TO FUNCTION OF IgD, Page 421
TURNING CELLS ON AND OFF: TRIGGERING AND TOLERANCE, Pages 423-425, John Cambier
B CELL TRIGGERING AND TOLERANCE: ROLE OF SURFACE RECEPTORS, Pages 427-430, D.W. Scott
HEAVY CHAIN CLASS SWITCHING AND A ROLE FOR IMMUNOGLOBULIN D, Pages 431-433, R.M.E. Parkhouse
AN ALTERNATIVE ROLE FOR IgD, Pages 435-437, E.S. Vitetta
A ROLE FOR IgD: DISSOCIATION OF MEMORY INDUCTION FROM AFFINITY MATURATION, Pages 439-440, Leonore A. Herzenberg, Samuel J. Black, Takeshi Tokuhisa, Leonard A. Herzenberg
INTRODUCTION TO LYMPHOCYTE MATURATION, Page 441
RECEPTOR AND MARKER EXPRESSION DURING DIFFERENTIATION AND MATURATION, Pages 443-445, Alan Williamson
SURFACE IMMUNOGLOBULINS (Ig) AND PHYSIOLOGICAL CHARACTERISTICS OF VIRGIN AND MEMORY B CELLS, Pages 447-449, S. Strober
DIFFERENTIAL LIGHT CHAIN EXPRESSION, Pages 451-452, B. Blomberg
CLONAL AND NONCLONAL SELECTION AND EXPANSION OF B CELLS, Pages 453-455, Stratis Avrameas
SINGLE CELLS RESPONDING TO TWO UNRELATED ANTIGENS, Pages 457-462, P. Liacopoulos, J. Couderc
CLASS SWITCHING IN B CELLS, Page 463, M. Brittle, J.H.L. Playfair
COMMENTS ON THYMOCYTE AND T CELL DIFFERENTIATION CORRELATED WITH FUNCTION, Pages 465-466, Bonnie J. Mathieson
ON THE RELATIONSHIP BETWEEN Lyt PHENOTYPES, MHC SUBREGIONS, AND T CELL FUNCTION, Pages 467-470, Susan L. Swain, Richard W. Dutton
INTRODUCTION TO IDIOTYPIC REGULATION, Page 471
IDIOTYPIC NETWORKS, RESTRICTIVE RECOGNITION, AND REGULATION IN THE IMMUNE SYSTEM, Pages 473-479, J. Urbain
THE NATURE OF RECEPTOR ANTIBODIES ON T LYMPHOCYTES, Pages 481-482, Olli Mäkelä
THE ANTIGEN BRIDGE AND IDIOTYPIC INTERACTIONS AS PARALLEL COMMUNICATION SYSTEMS, Pages 483-485, Luciano Adorini, Michael Harvey, Eli Sercarz
ANALOGOUS DUAL SPECIFICITY OF HELPER T CELLS COOPERATING IN THE GENERATION OF CLONALLY RESTRICTED ANTIBODY RESPONSES, Pages 487-492, K. Bottomly, D.E. Mosier
CLONAL DOMINANCE–A PRODUCT OF IDIOTYPE-SPECIFIC INTERACTION, Pages 493-495, Heinz Köhler
RELIABLE VACCINES USING HYBRIDOMA PRODUCTS WITH DEFINED IDIOTYPES, Pages 497-498, A.J. Cunningham
INTRODUCTION TO CONTROL OF ANTI SELF REACTIONS, Page 499
CONTROL OF AUTOIMMUNITY, Pages 501-502, Norman Talal
AUTOIMMUNITY, Pages 503-504, Alfred D. Steinberg
SPECIFICITY OF T SUPPRESSORS OF AUTOIMMUNITY, Pages 505-506, A. Cooke, P.R. Hutchings, J.H.L. Playfair
HOW A SPECIFIC ANTISELF DELETION MECHANISM CAN AFFECT THE GENERATION OF THE SPECIFICITY REPERTOIRE, Pages 507-512, Richard G. Miller
SELF-TOLERANCE: AN ALTERNATIVE VIEW, Pages 513-516, Erwin Diener, Cory A. Waters
VARYING SENSITIVITY TO TOLERANCE INDUCTION THROUGHOUT MATURATION, Pages 517-520, G.J.V. Nossal
CENTRAL VERSUS PERIPHERAL MECHANISMS IN THE CONTROL OF ANTISELF REACTIONS, Pages 521-522, William O. Weigle
THE BROAD SPECTRUM OF AUTOANTIGENS AND THE FUNCTION OF SELF-REACTIVE T AND B CELLS, Pages 523-527, Noel R. Rose
AUTOIMMUNITY AS A REFLECTION OF IMMUNE DEFICIENCY OF T CELL SUBPOPULATIONS, Pages 529-532, H. Hugh Fudenberg
INDEX, Pages 533-537