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نویسندگان: Andrei Hent and John Andraos
سری:
ISBN (شابک) : 9780128128237
ناشر: Academic Press
سال نشر: 2019
تعداد صفحات: 873
زبان: English
فرمت فایل : PDF (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود)
حجم فایل: 34 مگابایت
در صورت تبدیل فایل کتاب Strategies and Solutions to Advanced Organic Reaction Mechanisms به فرمت های PDF، EPUB، AZW3، MOBI و یا DJVU می توانید به پشتیبان اطلاع دهید تا فایل مورد نظر را تبدیل نمایند.
توجه داشته باشید کتاب استراتژی ها و راه حل های مکانیزم های پیشرفته واکنش آلی نسخه زبان اصلی می باشد و کتاب ترجمه شده به فارسی نمی باشد. وبسایت اینترنشنال لایبرری ارائه دهنده کتاب های زبان اصلی می باشد و هیچ گونه کتاب ترجمه شده یا نوشته شده به فارسی را ارائه نمی دهد.
استراتژیها و راهحلهای مکانیزمهای واکنش آلی پیشرفته: دیدگاهی جدید در مورد مشکلات مککیلوپ بر اساس متن محبوب الکساندر (ساندی) مککیلوپ، راهحلهایی برای مشکلات پیشرفته مککیلوپ در مکانیسمهای واکنش آلی، یک رویکرد روششناختی واحد را ارائه میکند. رسیدگی به مشکلات مکانیسم واکنش آلی این کتاب منحصر به فرد، منطق، بینش تجربی و رویکردهای راهبرد حل مسئله موجود در هنگام برخورد با مشکلات مکانیسم واکنش آلی را تشریح می کند. این روشهای ارزشمند بر رویکردی ساختاریافته و کاربردی که هم برای دانشآموزان و هم برای متخصصان این حوزه مرتبط است، تأکید دارند. با استفاده از روش های شرح داده شده، دانشجویان و محققان پیشرفته به طور یکسان قادر خواهند بود با مشکلات مکانیسم واکنش آلی، از ساده و مستقیم تا پیشرفته، مقابله کنند. روشهای راهبردی را برای حل مسائل مکانیکی پیشرفته ارائه میکند و آن تکنیکها را برای 300 مسئله اصلی در اولین انتشار به کار میبرد. در دسترس است تا به دانشجویان و محققان پیشرفته در انتخاب پروژه تحقیقاتی بعدی خود کمک کند
Strategies and Solutions to Advanced Organic Reaction Mechanisms: A New Perspective on McKillop\'s Problems builds upon Alexander (Sandy) McKillop\'s popular text, Solutions to McKillop\'s Advanced Problems in Organic Reaction Mechanisms, providing a unified methodological approach to dealing with problems of organic reaction mechanism. This unique book outlines the logic, experimental insight and problem-solving strategy approaches available when dealing with problems of organic reaction mechanism. These valuable methods emphasize a structured and widely applicable approach relevant for both students and experts in the field. By using the methods described, advanced students and researchers alike will be able to tackle problems in organic reaction mechanism, from the simple and straight forward to the advanced. Provides strategic methods for solving advanced mechanistic problems and applies those techniques to the 300 original problems in the first publication Replaces reliance on memorization with the understanding brought by pattern recognition to new problems Supplements worked examples with synthesis strategy, green metrics analysis and novel research, where available, to help advanced students and researchers in choosing their next research project
Front-Matter_2019_Strategies-and-Solutions-to-Advanced-Organic-Reaction-Mech Front Matter Copyright_2019_Strategies-and-Solutions-to-Advanced-Organic-Reaction-Mechani Copyright Dedication_2019_Strategies-and-Solutions-to-Advanced-Organic-Reaction-Mechan Dedication Preface_2019_Strategies-and-Solutions-to-Advanced-Organic-Reaction-Mechanism Preface The Purpose of Writing This Book What This Book Offers Organization of Book and Layout of Solutions Acknowledgments References Chapter-1---The-Logic-of-Organic_2019_Strategies-and-Solutions-to-Advanced-O The Logic of Organic Reaction Mechanisms What is an Organic Chemical Reaction? The Balanced Chemical Equation What Is Contained in a Reaction Scheme? Principle of Conservation of Structural Aspect Curly Arrow Notation Baeyer-Villiger Oxidation Mechanism Table of Recommended Textbooks on Physical Organic Chemistry Base Strength and pKA Autoxidation References Chapter-2---Evidence-for-Organic_2019_Strategies-and-Solutions-to-Advanced-O Evidence for Organic Reaction Mechanisms What Is Physical Organic Chemistry? Experimental Physical Organic Chemistry Applying Experimental Techniques-Baeyer-Villiger Oxidation Revisited References Chapter-3---Problem-Solving-Organ_2019_Strategies-and-Solutions-to-Advanced- Problem Solving Organic Reaction Mechanisms Theoretical Problem-Solving Strategy Experimental Problem-Solving Strategy Case Study: Rearrangement of Cinenic Acid to Geronic Acid Current State of Pedagogy and Academic and Future Directions References Chapter-4---Solutions-_2019_Strategies-and-Solutions-to-Advanced-Organic-Rea Solutions 1 - 50 A Tandem Route to 1,2,3,4-Tetrasubstituted Naphthalenes Solution: 1 to 2 Solution: 2 to 3 Solution: D to 4 Balanced chemical equations Key Steps Explained Additional Resources References Hydroazulenes by Radical Cyclization Solution Balanced chemical equation Key Steps Explained Additional Resources References Cinnolines to Indoles Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Rearrangement During NMR Studies Solution Key Steps Explained Additional Resources References Synthesis of Trifluoromethyl Heterocycles Solution: 1 to 2 Solution: 2 to 3 Solution: 3 to 4 Balanced chemical equations Key Steps Explained Additional Resources References 3-Substituted Chromones From Pyranobenzopyrans Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Acid-Catalyzed Rearrangements of 1-Arylindoles Solution: 1 to 2 Balanced Chemical Equation Key Steps Explained Additional Resources References An Unusual Deprotection of an Aryl Ester Solution: 2 to 3 Balanced Chemical Equation Key Steps Explained Additional Resources References 3,1-Benzoxathiin Formation Solution: Mechanism 1 Solution: Mechanism 2 Key Steps Explained Additional Resources References Arylacetone Synthesis by Carroll-Type Rearrangement Solution: 1 and 2 to 3 Solution: 3 to 4 Key Steps Explained Additional Resources References Attempted Knoevenagel Reaction Gives Mannich-Type Products Solution: 1 to 2 Balanced Chemical Equation: 1 to 2 Solution: 3 to 2 Balanced Chemical Equation: 3 to 2 Key Steps Explained Additional Resources References Pyridinium Salt Rearrangements Solution: 1 to 2 Solution: 3 to 4 Balanced Chemical Equations Key Steps Explained Additional Resources References A Pyridazine From a Thiophene Dioxide Solution: 1 and 2 to 3 Solution: 3 to 4 Balanced Chemical Equations Key Steps Explained Additional Resources References Biomimetic Synthesis of Litebamine Solution: 1 to 2 Balanced Chemical Equation: 1 to 2 Solution: 4 to 5 Solution: 5 to 6 Balanced Chemical Equation: 5 to 6 Key Steps Explained Additional Resources References Acid-Catalyzed Degradation of N-Nitroso-2,3-didehydromorpholine Solution Balanced Chemical Equation Key Steps Explained Additional Resources References A New Route to 4-Amino-3-arylcinnolines Solution: 2 to 3 (Path a) Solution: 2 to 3 (Path b) Balanced Chemical Equation Key Steps Explained Additional Resources References Base-Induced Cyclizations of o-Ethynylaryl-Substituted Benzyl Alcohols Solution: 1 to 2 Solution: 3 to 5 Key Steps Explained Additional Resources References Trifluoromethylpyrroles From Trifluoromethyloxazolones Solution Balanced Chemical Equation Key Steps Explained Additional Resources References The Hooker Oxidation Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Synthesis of 1,3-Disubstituted Pyrroles Solution: 3 to 4 Balanced Chemical Equation Key Steps Explained Additional Resources References Grob Fragmentation of a 1-Azaadamantane Solution: 1 to 2 Balanced Chemical Equation Solution: 2 to 3 Balanced Chemical Equation Key Steps Explained Additional Resources References Selective Substitution of 3-Methoxypyrazine N-Oxide Solution: 1, 2, and 3 to 4 (When ZnBr2 Present) Balanced Chemical Equation Key Steps Explained Additional Resources References Reactions of Ethacrylate Esters With NO2BF4 Solution: 1 to 2 Solution: A to 3 Solution: 4 to 5 Balanced Chemical Equation: 4 to 5 Solution: C to 6 Balanced Chemical Equation: 4 to 6 Key Steps Explained Additional Resources References A Furan Synthesis Solution: 1 to 2 Solution: 2 to 3 (Authors Mechanism) Balanced Chemical Equations Key Steps Explained Additional Resources References Dimerization of Vinca Alkaloids Solution Key Steps Explained Additional Resources References Nitration of a Quinoline Derivative Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Synthesis of Binaphthyldiquinones Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Heterocyclic Fun With DMAD Solution: Mechanism 1 Solution: Mechanism 2 Balanced Chemical Equation Key Steps Explained Additional Resources References Unexpected Formation of a 1,5-Benzodiazonine Solution Balanced Chemical Equation Key Steps Explained Additional Resources References A Thiopyran to Thiophene Transformation Solution: 1 to 2 Solution: 3 to 4 (Path a: F to 4) Solution: 3 to 4 (Path b: F to 4) Balanced Chemical Equations Key Steps Explained Additional Resources References Skeletal Rearrangements of a Diterpene Solution: 1 to 2 Solution: B to 4 Solution: 4 to 3 Solution: 3 to 5 Balanced Chemical Equations Key Steps Explained Additional Resources References Reissert Reactions of Quinoxaline N-Oxides Solution: 1 to 2 Solution: 1 to 3 Solution: 4 to 5 Balanced Chemical Equations Key Steps Explained Additional Resources References Unexpected Results in Directed Metalation Solution: 3 to 4/5 Key Steps Explained Additional Resources References 1,4-Dioxene in Synthesis Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Collins Oxidation of Phenylethanols Solution: 1 to 2 Solution: 4 to 5 Balanced Chemical Equations Key Steps Explained Additional Resources References Allene Sulfoxide Rearrangement Solution: 2 to 3 Solution: 3 to 4 Balanced Chemical Equations Key Steps Explained Additional Resources References A Failed ``Pinacol-Type´´ Rearrangement Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Allylation of 1,4-Benzoquinones Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Benzopyrene Synthesis-By Accident Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Rearrangement of Ketene Acetals Solution: 2E to 3 Solution: 2Z to 3 Balanced Chemical Equation Key Steps Explained Additional Resources References Nucleophilic Additions to a Heterocyclic o-Quinone Solution: 1 to 2 Solution: 1 to 3 Key Steps Explained Additional Resources References How Mitomycin C Can Crosslink DNA Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Two Carbon Ring Expansions of Cycloalkanones Solution: 1 to 2 Balanced Chemical Equation: 1 to 2 Solution: 3 to 4 Balanced Chemical Equation: 3 to 4 Solution: 3 to 5 Balanced Chemical Equation: 3 to 5 Key Steps Explained Additional Resources References Fulgides: Synthesis and Photochromism Solution: 1 and 2 to 3 (Stobbe Condensation) Balanced Chemical Equation: 1 and 2 to 3 Solution: 3 to 4 (Lactone Opening Esterification) Balanced Chemical Equation: 3 to 4 Solution: 4 to 5 (Stobbe Condensation) Balanced Chemical Equation: 4 to 5 Solution: 5 to 6 (Saponification of Diester to Diacid) Balanced Chemical Equation: 5 to 6 Solution: 6 to 7 Balanced Chemical Equation: 6 to 7 Solution: 7 to 8 (Base-Assisted Ring Opening Alkylation) Balanced Chemical Equation: 7 to 8 Solution: 8 to 9 (Acetyl Chloride-Assisted Cyclization) Balanced Chemical Equation: 8 to 9 Solution: 9 to 10 (Photochromism Mechanism) Key Steps Explained Additional Resources References Benzodiazepines From (R)-(+)-Pulegone Solution Key Steps Explained Additional Resources References A Furan to Pyran Ring Expansion Solution: 1 to 2 (Mechanism 1: Consistent With Deuterium Labeling Study) Solution: 1 to 2 (Mechanism 2: Inconsistent With Deuterium Labeling Study) Key Steps Explained References A Structure and Mechanism Correction Solution: 1 and 2 to 3 (Claimed Reaction) Solution: 3 to 4 (Claimed Reaction) Solution: 1 and 2 to 5 (Actual Reaction) Solution: 5 to 4 (Actual Reaction) Balanced Chemical Equations Key Steps Explained Additional Resources References Propargylbenzotriazoles to Five-membered Heterocycles Solution: 1 and 2 to 3 Balanced Chemical Equation: 1 and 2 to 3 Solution: 3 to 4 Balanced Chemical Equation: 3 to 4 Key Steps Explained Additional Resources References From Carvone to an Isoxazoloazepine Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Isoxazoles From Cyclopropanes Solution: 1 to 2 Balanced Chemical Equation Key Steps Explained Additional Resources References Chapter-5---Solutions-5_2019_Strategies-and-Solutions-to-Advanced-Organic-Re Solutions 51 - 100 A Radical Cascade From a Ketene Dithioacetal Solution Balanced Chemical Equation Key Steps Explained Additional Resources References A Synthesis of 3-Alkyl-1-naphthols Solution: 2 to 3 Solution: 4 to 5 Solution: 6 to 7 Key Steps Explained Additional Resources References An Entry to Indole Alkaloids of Unusual Structural Type Solution: 1 to 2 Solution: 2 to 3 Solution: 3 to 5 and 4 Balanced Chemical Equations Key Steps Explained Additional Resources References Cyclization as a Key Step to Hirsutene Solution Key Steps Explained Additional Resources References A 1,3-Cyclopentanedione to 1,4-Cyclohexanedione Transformation Solution: Originally Proposed Mechanism for 1 to 2 Solution: Revised Mechanism for 1 to 2 Part 1: 1 to 3 Solution: Revised Mechanism for 1 to 2 Part 2: 3 to 2 Key Steps Explained Additional Resources References Conversion of o-Hydroxyaryl Ketones Into 1,2-Diacylbenzenes Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Mechanisms of Bimane Formation Solution: 1 to syn-2 Solution: A and B to anti-2 Balanced Chemical Equation: 1 to syn-2/anti-2 Solution: 3 to syn-4 Balanced Chemical Equation: 3 to syn-4 Key Steps Explained Additional Resources References A Carbohydrate to Cyclopentanol Conversion Solution Balanced Chemical Equation Key Steps Explained Balanced Chemical Equation: Scheme 2 Balanced Chemical Equation: Scheme 3 Balanced Chemical Equation: Scheme 4 Additional Resources References Pyridazines From 1,2,4-Triazines Solution: 1 to 2 Using 15N Label on Phenylacetonitrile Solution: 2 to 3 Using 15N Label on Phenylacetonitrile Balanced Chemical Equations Key Steps Explained Additional Resources References Natural Product Degradation During Extraction and/or Chromatography Solution: Authors Proposal (Ionic Mechanism) Solution: Alternative Proposal (Radical Mechanism) Balanced Chemical Equation Key Steps Explained Additional Resources References Simple Access to Oxaadamantanes Solution: 1 to 2 Balanced Chemical Equation: 1 to 2 Solution: I to 3 Balanced Chemical Equation: 1 to 3 Solution: D to 4 Balanced Chemical Equation: 1 to 4 Key Steps Explained Additional Resources References A Pyrimidine Rearrangement Solution Balanced Chemical Equation Key Steps Explained Additional Resources References 1,4-Thiazin-3-ones From 1,4-Oxathiins Solution Balanced Chemical Equation Key Steps Explained Additional Resources References An Unusual Route to 3-Acylfurans Solution: 1 to 2 Solution: 2 to 3 Balanced Chemical Equations Key Steps Explained Additional Resources References Reaction of PQQ With l-Tryptophan Solution Additional Resources References An Unexpected Result From an Attempted Double Bischler-Napieralski Reaction Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Bis-Indole Alkaloid Formation Solution: 1 to 2 Solution: 3 to 4 and 5 Solution: 6 to 7 and 8 Balanced Chemical Equations Key Steps Explained Additional Resources References Azaphenalene Alkaloid Synthesis: A Key Step Solution: Path A Solution: Path B (C to 2 Alternative) Balanced Chemical Equation Key Steps Explained Additional Resources References A Primary Nitroalkane to Carboxylic Acid Transformation Solution: 1 to 2 Solution: 3 to 2 Balanced Chemical Equations Key Steps Explained Additional Resources References α-Diazoketones With Rhodium(II) Acetate Solution: 1 to 2 Solution: E to 3 Solution: C to J and 4 Balanced Chemical Equations Key Steps Explained Additional Resources References Pyrrolo[1,2-a]benzimidazole Synthesis by Ortho Nitro Interaction Solution: 1 to 2 Solution: H to 3 Solution: H to 4 Balanced Chemical Equations Key Steps Explained Additional Resources References Horner-Wittig Reaction on a Bifuranylidenedione Solution: 1 and 2 to 3 Solution: 3 to 4 Balanced Chemical Equations Key Steps Explained Additional Resources References Lactone Ammonolysis Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Intramolecular Schmidt Reaction Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Indolizidones by Intermolecular Photochemical Reaction Solution: 1 to E Solution: E to G Solution: G to 3 (Author Mechanism) Solution: G to 3 (Alternative Proposal) Balanced Chemical Equations Key Steps Explained Additional Resources References An Unexpected Product From Amine Oxidation Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Degradation of Pyripyropene A Solution: 1 to 2 Balanced Chemical Equation: 1 to 2 Solution: 2 to 3 and 4 Balanced Chemical Equation: 2 to 3 and 4 Key Steps Explained Additional Resources References Benzofurans From Cyclobutenediones Solution: 1 and 2 to 3 Solution: 3 to 4 Solution: 4 to 5 Solution: 5 to 6 Balanced Chemical Equations Key Steps Explained Additional Resources References Acid-Catalyzed Condensation of Indole With Acetone Solution Balanced Chemical Equation Key Steps Explained Additional Resources References A Synthesis of 2-Formylpyrrolidines Solution: 1 to 2 Solution: 2 to 3 Balanced Chemical Equation: 2 to 3 Solution: 3 to 4 Key Steps Explained Additional Resources References An Abnormal Claisen Rearrangement Solution Key Steps Explained Additional Resources References Benzoxepinones From Phthalides Solution Balanced Chemical Equation Key Steps Explained Additional Resources References m-Terphenyls From Pyrones Solution: 1 to 2 Solution: B to 3 Balanced Chemical Equations Key Steps Explained Additional Resources References A Cascade Reaction Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Photochemical Ortho Rearrangements Solution: 1 to 3 Balanced Chemical Equations Key Steps Explained Additional Resources References From Bicycle to Pentacycle to Tricycle Solution: 1 and 2 to 3 Solution: 3 to 4 Balanced Chemical Equation Key Steps Explained Additional Resources References Lewis Acid-Catalyzed Cyclopropyl Ketone Rearrangement Solution Key Steps Explained Additional Resources References An Intramolecular Ring Closure Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Photochemical Rearrangement of Pyran-2-ones Solution: 1 to 2 Solution: F to H (Alternative Path) Key Steps Explained Additional Resources References A Paclitaxel Rearrangement Solution Balanced Chemical Equation Key Steps Explained Additional Resources References An Ionic Diels-Alder Reaction Solution Balanced Chemical Equation Key Steps Explained Additional Resources References The Eschenmoser Fragmentation Reaction Extended Solution Balanced Chemical Equation Key Steps Explained Additional Resources References A Modified Batcho-Leimgruber Synthesis Solution: 1 to 4 p-TsOH Acid Catalysis Key Steps Explained Additional Resources References A Pyrone to Pyran Conversion Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Conformationally Rigid 4-Oxoquinolines Solution Balanced Chemical Equation Key Steps Explained Additional Resources References An Efficient Chromene Synthesis Solution: 1 and 2 to 3 Solution: 3 to 4 Balanced Chemical Equations Key Steps Explained Additional Resources References Flash Vacuum Pyrolysis of o-Xylylene Dimers Solution: 1 to 2 Solution: 3 to 4 Key Steps Explained Additional Resources References Synthesis of a Neocarzinostatin Building Block Solution Key Steps Explained Additional Resources References Oxazole Esters From α-Amino Acids Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Unexpected Formation of a Phenazine Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Chapter-6---Solutions-1_2019_Strategies-and-Solutions-to-Advanced-Organic-Re Solutions 101 - 150 Conversion of Primary Amides Into Nitriles Solution Balanced Chemical Equation Key Steps Explained Additional Resources References An Efficient Benzo[b]fluorene Synthesis Solution Balanced Chemical Equation Key Steps Explained Additional Resources References A Facile Synthesis of Tetracyclic Pyrroloquinazolines Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Ethyl 2-Chloronicotinate From Acyclic Precursors Solution: 1, 2, and 3 to 4 Solution: 4 to 5 Balanced Chemical Equation: 1, 2, and 3 to 4 Balanced Chemical Equation: 4 to 5 Key Steps Explained Additional Resources References A 2-Arylpropanoic Acid Synthesis Solution: 1 to 2 Solution: 2 to 3 Solution: 3 to 4 Balanced Chemical Equations Key Steps Explained Additional Resources References Synthesis of Isoquinolin-4-ones Solution: 1 to 2 Solution: 1 to 3 Key Steps Explained Additional Resources References Naphthopyrandione From 1,4-Naphthoquinone Solution: 1a to 3 Solution: 1b to 4 Balanced Chemical Equations Key Steps Explained Reference A Photochromic Product for Sunglasses Solution: 1 to 2 Solution: 2 to 3 Balanced Chemical Equations Key Steps Explained Additional Resources References A Quick Entry to the Aklavinone Ring System Solution Balanced Chemical Equation Key Steps Explained Additional Resources References A ``Stable Enol´´ That Doesnt Exist Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Conversion of an Indole-Based Bicyclo[5.3.1]undecane Into a Bicyclo[5.4.0]undecane Solution Balanced Chemical Equation Key Steps Explained Additional Resources References A Classical Mannich Approach to Isoquinoline Alkaloids Leads to an Unexpected Product Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Reaction of Benzothiazole With DMAD Solution Key Steps Explained Additional Resources References Inhibition of the l-DOPA to l-Dopaquinone Oxidation Solution Balanced Chemical Equation Key Steps Explained Additional Resources References A One-Pot Synthesis of 1,3,6,8-Tetramethyl-2,7-naphthyridine Solution: Formation of 1 Part 1 (A to H) Solution: Formation of 1 Part 2 (H to 1 Path A) Solution: Formation of 1 Part 3 (H to 1 Path B) Solution: Formation of 1 Part 4 (ALTERNATE ROUTE: B to O1) Solution: Formation of 1 Part 5 (ALTERNATE ROUTE: S to H) Solution: Formation of 2 Balanced Chemical Equations Key Steps Explained References Unexpected Course of a Mannich Reaction in Alkaloid Synthesis Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Synthesis of Thioindigo Solution Balanced Chemical Equation Key Steps Explained Additional Resources References An Unexpected Reaction During Studies of Amine Oxide Rearrangements Solution: 1 to 3 (Expected Product) Solution: 1 to 2 (Observed Product) Balanced Chemical Equation Key Steps Explained Additional Resources References An Unusual Phosphite-Induced Deoxygenation of a Nitronaphthalene Solution: 1 to 2 Authors Mechanism Solution: 1 to 2 Alternative Mechanism Solution: 3 to 2 Authors Mechanism Solution: 3 to 2 Alternative Mechanism Balanced Chemical Equation Key Steps Explained Additional Resources References A Benzimidazole to Pyrroloquinoxaline Transformation Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Acid-Catalyzed Benzophenone Isomerization Solution: Hayashi Mechanism1 Solution: Sandin Mechanism2 Solution: Wang Mechanism3 Key Steps Explained Additional Resources References 2-Oxabicyclo[1.1.0]butanone Is Not Easily Accessible Solution: Authors Mechanism Solution: Alternative Mechanism Balanced Chemical Equation Key Steps Explained Additional Resources References A Simple Synthesis of the Indole Alkaloid Yuehchukene Solution Key Steps Explained Additional Resources References Isoquinoline Rearrangement Solution Key Steps Explained Additional Resources References Multiple Sigmatropic Rearrangements Solution: 1 to 2 in PhCl Solution: 1 to 2 and 3 in PhCl and AIBN Solution: 1 to 3 in pTsOH Key Steps Explained Additional Resources References A Vilsmeier-Induced Annulation to Benzene Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Isopropylidene to 2-Alkyne Conversion Solution: Corey2 Mechanism Solution: Zard4 Mechanism Balanced Chemical Equations Key Steps Explained Additional Resources References A Tryptamine to Pentacyclic Indoline Transformation Solution: 1 to 2 Catalyst Regeneration Balanced Chemical Equation: 1 to 2 Solution: 1 to 3 Balanced Chemical Equation: 1 to 3 Key Steps Explained Additional Resources References Ring Contractions of a Dibenzothiepinone Solution: 1 to 2 Solution: 1 to 3 Solution: 1 to 4 Balanced Chemical Equations Key Steps Explained Additional Resources References Steroid Fragmentation With DDQ Solution: 1 to 2 Solution: 1 to 3 Solution: 1 to 4 Balanced Chemical Equations Key Steps Explained Additional Resources References A Base-Induced Vinylcyclopropane Rearrangement Solution Balanced Chemical Equation Key Steps Explained Additional Resources References 4-Demethoxydaunomycin: The Desired Result, but Not According to Plan Solution: 1 to 3 Solution: 3 to 4 Solution: 4 to 5 Solution: 5 to 2 Key Steps Explained Additional Resources References Three Isomeric Hexadienols Give the Same Bicyclic Lactone Solution: 1 to 4 Solution: 2 to 4 Solution: 3 to 4 Key Steps Explained Additional Resources References Degradation of Antibiotic X-537A Solution: 2 to 3 and A Solution: A to 5 Balanced Chemical Equation: 2 to 3 and 5 Solution: 2 to 4 Solution: D to 6 Balanced Chemical Equation: 2 to 3 and 6 Key Steps Explained Additional Resources References Steroid Rearrangements: Appearances Can Be Deceptive Solution Additional Resources References Synthesis of Eburna and Aspidosperma Alkaloids Solution: 2 to 3a and 3b Balanced Chemical Equation: 2 to 3a and 3b Solution: 2 to 4 and 5 Balanced Chemical Equations: 2 to 4 and 5 Key Steps Explained Additional Resources References Synthesis of Highly Hindered Cyclic Amines Solution: 1 to 2 Solution: 1 to 3 Balanced Chemical Equations: 1 to 2 and 3 Solution: 4 to 5 and 6 Balanced Chemical Equations: 4 to 5 and 6 Key Steps Explained Additional Resources References A 1,2-Dihydrobenzocyclobutane to Isochroman-3-one Conversion Solution Key Steps Explained Additional Resources References An Unexpectedly Facile Decarboxylation Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Regiospecific Synthesis of a 1,2-Dihydronaphthalene Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Degradation of Terramycin Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Synthesis of Bi-indane-l,3-dione Solution: 1 and 2 to 3 Solution: 3 to 4 Solution: 4 to 5 Solution: 5 to 6 Key Steps Explained Additional Resources References A Coumarin to Cyclopentenone Transformation Solution Balanced Chemical Equation Key Steps Explained Additional Resources References ``Synthetic Heroin´´ and Parkinsonism Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Rearrangement of 6-Hydroxyprotopine to Dihydrosanguinarine Solution Key Steps Explained Additional Resources References Biotin Synthesis: Sulfur Preempts a Beckmann Rearrangement Solution Key Steps Explained Additional Resources References A 1,4-Dithiin to Thiophene Rearrangement Solution: 1 to 2 Solution: 1 to 3 Balanced Chemical Equation: 1 to 3 Key Steps Explained Additional Resources References An Intramolecular Wittig Reaction Solution: 1 to 2 Solution: 1 to 3 Key Steps Explained Additional Resources References Amination of a Cephalosporin Solution: 1 to 2 Solution: 2 to 3 Key Steps Explained Additional Resources References A Uracil to 1,2,3-Triazole Conversion Solution: Authors Mechanism Solution: Alternative Mechanism Balanced Chemical Equation Key Steps Explained Additional Resources References Chapter-7---Solutions-1_2019_Strategies-and-Solutions-to-Advanced-Organic-Re Solutions 151 - 200 Schumm Devinylation of Vinyl Porphyrins Solution: Mechanism 1A Solution: Mechanism 1B Solution: Mechanism 2A Solution: Mechanism 2B Solution: Mechanism 3 Solution: Mechanism 4 Key Steps Explained Additional Resources References A Uracil to Substituted Benzene Transformation Solution: 1 to 2 Solution: 1 to 3 Key Steps Explained Additional Resources References γ-Lactones From Vinyl Sulfoxides Solution Key Steps Explained Additional Resources References Tetrahydrothieno[2,3-c]- and -[3,2-c]pyridine Synthesis Solution: 1 to 2 (Weakly Acidic Medium) Solution: 1 to 2 and 3 (Strongly Acidic Medium) Key Steps Explained Additional Resources References Oxothiolan Oxathian Oxothiolan Oxathian Solution: 1 to 2 Balanced Chemical Equation: 1 to 2 Solution: 2 to 3 Balanced Chemical Equation: 2 to 3 Solution: 3 to 4 Balanced Chemical Equation: 3 to 4 Key Steps Explained Additional Resources References A Thiazolopyrimidine to Pyrrolopyrimidine Transformation Solution: 1 and 2 to 3 Balanced Chemical Equation: 1 and 2 to 3 Solution: 3 to 6 to 5 Balanced Chemical Equation: 3 to 6 to 5 Solution: 5 to 4 Key Steps Explained Additional Resources References Oxidation of 1,5-Diacetoxynaphthalene With NBS Solution: 1 to 3 to 2 Balanced Chemical Equation: 1 to 3 Balanced Chemical Equation: 3 to 2 Balanced Chemical Equation: 4 to 2 Key Steps Explained Additional Resources References Badly Chosen Reaction Conditions? Solution Balanced Chemical Equation Key Steps Explained Additional Resources References One Step Synthesis of a Highly Symmetrical Hexacyclic System From a Simple Naphthol Solution Balanced Chemical Equation Key Steps Explained Additional Resources References A Method for Aryloxylation of p-Cresol Solution: 1 to 2 Balanced Chemical Equation: 1 to 2 Solution: 2 to 3 Solution: 2 to 3 Alternative Balanced Chemical Equation: 2 to 3 Solution: 3 to 4 Balanced Chemical Equation: 3 to 4 Solution: 3 to 5 Balanced Chemical Equation: 3 to 5 Key Steps Explained Additional Resources References Nitriles From N-Chlorosulfonylamides Solution: Nitrile Formation Via Triethylamine Solution: Nitrile Formation Via Dimethylformamide (DMF) Key Steps Explained Additional Resources References Synthesis of Perylenequinone Solution Balanced Chemical Equation Balanced Chemical Redox Equation Key Steps Explained Additional Resources References A Route to 2-Vinylindoles Solution Key Steps Explained Additional Resources References Brain Cancer: The Mechanism of Action of Temozolomide Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Attempted Nef-Type Reaction Leads to 3-Arylpyridine Synthesis Solution: Part 1-Reduction Solution: Part 2-Rearrangement Balanced Chemical Equation Key Steps Explained Additional Resources References The ArCOMe ArCCH Transformation Solution: 1 to 2 Balanced Chemical Equation: 1 to 2 Solution: 2 to 3 Balanced Chemical Equation: 2 to 3 Key Steps Explained Additional Resources References β-Amino Nitriles From Azetidones Solution Key Steps Explained Additional Resources References A New Route to 1,3-Disubstituted Naphthalenes Solution Balanced Chemical Equation Key Steps Explained Additional Resources References An Efficient Annulation Route to 6-Substituted Indoles Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Failure of a Rearrangement: From a Useful Compound to a Useless Product Solution Key Steps Explained Additional Resources References Synthesis of Trisubstituted Isoxazoles Solution: 1 to 2 and 2 to 3 Balanced Chemical Equation Key Steps Explained Additional Resources References 2,3-Dihydrobenzofurans From 1,4-Benzoquinones Solution: 1 and 2 to 3 and 3 to 4 Solution: 5 and 6 to 7 Solution: 7 to 8 Balanced Chemical Equation Key Steps Explained Additional Resources References Easy Construction of a Tricyclic Indole Related to the Mitomycins Solution: 1 to 2 Solution: 2 to 3 Key Steps Explained Additional Resources References Cycloaddition to a Benzothiopyrylium Salt Solution: 3 to 4 Solution: 3 to 5 Key Steps Explained Additional Resources References Benzotriazole From 1,2,4-Benzotriazine N-Oxides Solution: 1 to 3 Solution: 2 to 3 Key Steps Explained Additional Resources References A Furan Furan Transformation Solution Key Steps Explained Additional Resources References Ring Expansion of Both Rings of Penicillin Sulfoxides Solution Balanced Chemical Equation Key Steps Explained Additional Resources References A Retro-Pictet-Spengler Reaction Solution: Epimerization Mechanism 1 (C1N2 Bond Scission) Solution: Epimerization Mechanism 2 (Olefin Protonation) Solution: Epimerization Mechanism 3 (Iminium Ion Formation) Solution: Degradation Mechanism 1 (Retro-Pictet-Spengler) Path A Solution: Degradation Mechanism 1 (Retro-Pictet-Spengler) Path B Key Steps Explained Additional Resources References An Olefin to α-Hydroxy Ketone Transformation Solution Balanced Chemical Equation Key Steps Explained Additional Resources References A Benzofuran From a Cyclopropachromone Solution Balanced Chemical Equation Key Steps Explained Additional Resources References A Pyridocarbazole to Pyridazinocarbazole Rearrangement Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Substituent Group Effect During Sulfide Sulfoxide Oxidation Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Ring Contraction of a Benzodiazepine Solution: Mechanism 1A (Authors Mechanism) Solution: Mechanism 1B (Authors Mechanism) Solution: Mechanism 2 (Alternative Mechanism) Balanced Chemical Equation Key Steps Explained Additional Resources References An Indane-1,3-dione Synthesis Solution: Mechanism 1 (Mosher and Meier) Solution: Mechanism 2 (Alternative) Balanced Chemical Equation Key Steps Explained Additional Resources References An Azepine to Cyclohexadienone Ring Contraction Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Xanthopterin From Pterin 8-Oxide Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Fused Dihydro-l,4-dithiins From Chromanones Solution Balanced Chemical Equation Key Steps Explained Additional Resources References The ``Additive Pummerer Reaction´´ Solution: 1 to 3 Solution: 1 to 4 Key Steps Explained Additional Resources References An Illustration of the Problem of Artifacts in Natural Product Chemistry Solution Key Steps Explained Additional Resources References Vinylogy, and a Stereochemical Puzzle Solution: Mechanism 1 (Kiehlmann et al.) Balanced Chemical Equation: Mechanism 1 Solution: Mechanism 2 (Acevado et al.) Balanced Chemical Equation: Mechanism 2 Key Steps Explained Additional Resources References A Simple, High Yielding Route to a Cage Compound Solution: 1 to 2 Solution: 1 to 3 Key Steps Explained Additional Resources References Not All Ketals Hydrolyze Easily in the Expected Manner Solution: 1 to 2 Solution: 1 to 2 and 3 Key Steps Explained Additional Resources References From a Tricycle to a Ring Expanded Bicycle Solution Key Steps Explained Additional Resources References A Flavone From a Chromanone Solution: 1 to 2 Solution: 2 to 3 (at Elevated Temperature) Solution: 2 to 4 (at Elevated Temperature NO Added Base) Solution: 1 to 4 (With Added Base) Key Steps Explained Additional Resources References Thiophene Ylide Rearrangement Solution Key Steps Explained Additional Resources References A Stepwise 2π+2π Intermolecular Cycloaddition Solution Key Steps Explained Additional Resources References Rearrangement of an Aryl Propargyl Ether Solution Key Steps Explained Additional Resources References The Best Laid Plans Solution: 1 to 2 (Expected Result) Step 1 Solution: 1 to 2 (Expected Result) Step 2 Solution: 1 to 3 (Observed Result) Alternative Pathway From Intermediate D Balanced Chemical Equations Key Steps Explained Additional Resources References A New Synthesis of Substituted Ninhydrins Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Thermal Elimination Reactions Often Fail Solution Key Steps Explained Additional Resources References Chapter-8---Solutions-2_2019_Strategies-and-Solutions-to-Advanced-Organic-Re Solutions 201 - 250 The Wrong Choice of Reaction Conditions? How Not to Prepare an Acid Chloride Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Quantitative Yield Isomerization of a Xylenol Derivative Solution Key Steps Explained Additional Resources References and an Alternative Route to the Starting Material for Problem 202 Solution: 1 to 2 Solution: 1 to A Solution: A to 2 Key Steps Explained Additional Resources References Hydride-Induced Rearrangements With Indole Alkaloid Intermediates Solution Balanced Chemical Equation Work-Up Reaction Key Steps Explained Additional Resources References An Unusual ``Hydrolysis´´ Product of 2-Nitrosopyridine Solution Balanced Chemical Equation Key Steps Explained Additional Resources References A Quinolizine to Indolizine Transformation Solution: 1 to A Solution: A to 2 Key Steps Explained Additional Resources References SNHetAr Reactions Often Proceed With Complications Solution: 1 to 2 (ipso Substitution) Solution: 1 to 3 (tele Substitution) Solution: 1 to 4 (ANRORC Mechanism) Balanced Chemical Equations Key Steps Explained Additional Resources References Rearrangement During Recrystallization Solution: 1 and 2 to 3 Solution: 3 to 4 Solution: 4 to 5 Balanced Chemical Equation (4 to 5) Key Steps Explained Additional Resources References Another Attempt to Reduce a Ketone Goes Wrong Solution Balanced Chemical Equation Key Steps Explained Additional Resources References A More Complex Benzocyclobutane to Isochroman-3-one Rearrangement (c.f. Problem 138) Solution Key Steps Explained Additional Resources References Indoles by Solvometalation Ring Closure Solution Balanced Chemical Equation Key Steps Explained Additional Resources References An Unusual-But Inefficient-Synthesis of Methyl 1-Hydroxynaphthalene-2-carboxylate Solution: Mechanism A Solution: Mechanism B Solution: Mechanism C Key Steps Explained Additional Resources References Synthesis of α-Arylalkanoic Acids From Acetophenones Solution: B to C Solution: C to D Solution: D to 2 Key Steps Explained Additional Resources References Triazene-Triazole-Triazole Interconversions Solution: 1 to 2 to 3 Key Steps Explained Additional Resources References Reissert Compounds as Precursors to Novel Phthalides Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Di-t-butylacetylene Does Not Cycloadd to 2-Pyrone Solution Key Steps Explained Additional Resources References A Failed Thorpe-Dieckmann Cyclization: ``Obvious´´ Reactions Are Not Always Well Behaved Solution Balanced Chemical Equation Key Steps Explained Additional Resources References and Can Lead to Remarkable Rearrangements: A Failed Thorpe-Ziegler Cyclization Solution Key Steps Explained Additional Resources References A Remarkably Stable Tertiary Alcohol by Solvolysis of a Primary Tosylate Solution: Mechanism A-Bornyl Path (Helicopter View) Solution: Mechanism B-Fenchyl Path (Helicopter View) Key Steps Explained Additional Resources References ``Anionic Activation´´ for the Preparation of Fluoroheterocycles Solution: 1 to 2 Via Phenylacetylene Balanced Chemical Equation: 1 to 2 Via Phenylacetylene Solution: 1 to 2 Via Acetophenone Balanced Chemical Equation: 1 to 2 Via Acetophenone Solution: 3 to 4 Balanced Chemical Equation: 3 to 4 Key Steps Explained Additional Resources References Synthesis of a 5-(2-Quinolyl)pyrimidine Solution: B to C Balanced Chemical Equation: B to C Key Steps Explained Additional Resources References ``Obvious´´ and ``Nonobvious´´ Pathways to a Highly Substituted Pyridine and Aniline Solution: Formation of 3 Balanced Chemical Equation for Formation of 3 Solution: Formation of 4 Obvious Pathway Balanced Chemical Equation for Formation of 4 Obvious Pathway Solution: Formation of 4 Nonobvious Pathway Balanced Chemical Equation for Formation of 4 Nonobvious Pathway Key Steps Explained Additional Resources References A 1-Isoquinolone Synthesis Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Selective Cleavage of the Mycinose Sugar From the Macrolide Antibiotic Tylosin Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Unexpected Formation of an Enamide Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Highly Functionalized Furans From 3-Bromochromone Solution Key Steps Explained Additional Resources References A One-Pot Benzene Naphthalene Transformation Solution Key Steps Explained Additional Resources References Vicarious Nucleophilic Substitution Routes From Simple to Complex Phenols Solution: Formation of 1 Solution: Formation of 2 (Mechanism Version 1) Solution: Formation of 3 (Mechanism Version 2) Solution: Formation of 4 (Mechanism Version 3) Key Steps Explained Additional Resources References Lewis Acid-Catalyzed Rearrangement of Humulene 8,9-Epoxide Solution Key Steps Explained Additional Resources References From a Dihydrofuran to an Indole-3-acetate Solution: Formation of 1 Solution: Formation of 2 Key Steps Explained Additional Resources References Reaction of Fervenulin 4-Oxide With DMAD: The Role of Solvent Solution: 1 2 Solution: 1 3 Solution: 1 4 Balanced Chemical Equations Key Steps Explained Additional Resources References Rearrangement of 4-Quinazolinylhydrazines Solution: Rearrangement Under Neutral pH Solution: Hydrolysis Under Acidic pH Solution: Hydrolysis Under Basic pH Key Steps Explained Additional Resources References A Failed Approach to the Oxetan-3-one System Balanced Chemical Equations Additional Resources References Tricyclics From Furfural Solution: Furfural to 2 Solution: 2 to 3 Solution: 3 to 4 Solution: 4 to 5 Solution: 5 to 6 Key Steps Explained Additional Resources References Further Reading An Ylide-Based Synthesis of 4-Phenylisocoumarin Solution: 1 2 Solution: 2 3 Balanced Chemical Equations Key Steps Explained Additional Resources References Model Studies for Mitomycin A Synthesis Lead to a New Preparation of Pyrroloindoles Solution: 1 2 Solution: 1 3 Solution: 1 4 Key Steps Explained Additional Resources References Formation of N-Cyanofluoren-9-imine From 9-Dinitromethylenefluorene Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Methylphenylacetic Acids From Butenolides Solution: 1 2 Solution: 3 4 Key Steps Explained Additional Resources References Base-Induced Quinoline Rearrangements Solution Balanced Chemical Equation Key Steps Explained Additional Resources References The Angucyclines: Rearrangement of Angular to Linear Tetracycles Solution Key Steps Explained Additional Resources References 1,2-Dihydropyridines From 2,3-Dihydro-4-pyridones Solution Key Steps Explained Additional Resources References The Vitamin K to Vitamin K Oxide Transformation Solution: Mechanism 1 Solution: Mechanism 2 Key Steps Explained Additional Resources References Rearrangement During Intramolecular Cyclization to the Indole 4-Position Solution Key Steps Explained Additional Resources References 4-Quinolone Antibacterials: A New Synthesis Solution: 1 to 2 Solution: 2 to 3 Solution: 3 to 4 Key Steps Explained Additional Resources References An Efficient Synthesis of Fused 1,3-Dithiol-2-ones Solution Key Steps Explained Additional Resources References The ``Double Functional Group Transformation´´: Terminally Unsaturated Nitriles From 1-Nitrocycl ... Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Lewis Acid-Catalyzed Condensation of Indole With 1,3-Cydohexanedione Solution: Formation of 1 Solution: Formation of 2 Key Steps Explained Additional Resources References Serendipitous Preparation of a Pyrrole Precursor to Porphyrins Solution Balanced Chemical Equation Key Steps Explained Additional Resources References A Chromone Ring Contraction Solution Balanced Chemical Equation Key Steps Explained Additional Resources References A Simple Conversion of Hydroquinone to a Benzofuran, but Which Mechanism? Solution: Mechanism 1 (C-Alkylation-Lactonization) Solution: Mechanism 2 (O-Alkylation-Michael-Lactonization) Balanced Chemical Equation Key Steps Explained Additional Resources References Chapter-9---Solutions-2_2019_Strategies-and-Solutions-to-Advanced-Organic-Re Solutions 251 - 300 A Remarkable Loss of One Carbon Atom in the Indole Alkaloid Field Solution Solution-Possibility 1 (With Intervention of Retro-Mannich Process) Solution-Possibility 2 (Without Intervention of Retro-Mannich Process) Balanced Chemical Equation Key Steps Explained Additional Resources References A ``Nonobvious´´ Cycloaddition Reaction Solution Balanced Chemical Equation Key Steps Explained Additional Resources References More Radical Cascades and a Formal [2+2+2] Cycloaddition of a Dienyne Solution Key Steps Explained Additional Resources References LTA-Induced Acetoxylation and Rearrangement of a Phenol Key Steps Explained Solution Balanced Chemical Equation Mechanism for 3 Additional Resources References How Cocaine Decomposes at 550C Solution Key Steps Explained Additional Resources References A Highly Efficient Anilide to Benzimidazole Transformation Solution Balanced Chemical Equation Key Steps Explained Additional Resources References The Baeyer-Drewson Synthesis of Indigo Solution Balanced Chemical Equation Key Steps Explained Additional Resources References The Marschalk Reaction Solution Balanced Chemical Equation Key Steps Explained Additional Resources References A 1,3-Cyclohexanedione to 2-Cyclohexenone Conversion Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Reaction of a Steroidal Olefin With Br2/AgOAc Key Steps Explained Solution Balanced Chemical Equation Additional Resources References A Most Unusual Synthesis of Tropones From Phenols Solution: 1 to 2 Solution: 3 to G Solution: G to 4 Balanced Chemical Equation: G to 4 Key Steps Explained Additional Resources References Side-Chain Manipulation With a Purine Derivative: Unexpected Formation of a Thietane Solution Key Steps Explained Additional Resources References An Isoxazoline to Pyridine N-Oxide Transformation Solution Key Steps Explained Additional Resources References A Simple Synthesis of the Lignan Carpanone Solution Key Steps Explained Additional Resources References Cyclopentaquinolines by Tandem Reactions Solution Experimental Results and Verification Additional Resources References Epimerization of Herqueinone Solution: Brooks Mechanism Solution: Proposed Mechanism Key Steps Explained Additional Resources References A New Method for Amide Bond Formation Solution Key Steps Explained Additional Resources References A Benzothiazole From Oxidation of Mammalian Red Hair With Hydrogen Peroxide Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Cyclopentenones From 1,3-Cyclopentanediones Solution: 12 Solution: C3 Key Steps Explained Additional Resources References A New Synthesis of 1- and 2-Chloronaphthalenes by an Annulation Process Solution: 1 2 Solution: 3 4 Key Steps Explained Additional Resources References From the Diterpene Carnosol to the Benzodiazepine Agonist Miltirone Solution: 1A Solution: A2a Solution: A2b Balanced Chemical Equation: 12a Solution: 2b3 Solution: 34 Balanced Chemical Equation: 12b Balanced Chemical Equation: 2b3 Balanced Chemical Equation: 34 Key Steps Explained Additional Resources References Synthesis of Chiral Phthalimidine Derivatives Solution: Synthesis of 1 Solution: Synthesis of 1: Pathway A Solution: Synthesis of 1: Pathway B Solution: Synthesis of 2 Balanced Chemical Equation for the Synthesis of 1 Key Steps Explained Additional Resources References Remarkable Rearrangement of a Camphor Derivative Solution Balanced Chemical Equation Key Steps Explained Additional Resources References A Failed Attempt to Prepare Benzylidenethiophthalide by the ``Obvious´´ Method Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Base-Catalyzed Reactions of Highly Hindered Phenols Used as Antioxidants Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Oxidative Rearrangement of an Aconitine Derivative Solution: 1 to 2 Balanced Redox Chemical Equation for 1 to 2 Solution: 2 to 3 Balanced Chemical Equation for 2 to 3 Key Steps Explained Balanced Chemical Equation for Hydroxydiphenylacetaldehyde to Benzophenone Transformation Additional Resources References Decomposition of Akuammicine Solution: Decomposition at 100C Solution: Decomposition at 140C Balanced Chemical Equation: Decomposition at 100C Balanced Chemical Equation: Decomposition at 140C Key Steps Explained Additional Resources References Extending the Favorskii Reaction Solution: 12 Solution: 13 Solution: 14 Balanced Chemical Equation: 12 Balanced Chemical Equation: 13 Balanced Chemical Equation: 14 Key Steps Explained Additional Resources References Dihydroxylation/Base Treatment of the Westphalen Ketone Solution: 1A Balanced Chemical Equation: 1A Solution: A2 Solution: B3 Balanced Chemical Equation: A2 Balanced Chemical Equation: 23 Key Steps Explained Additional Resources References Quantitative Conversion of a Vinylogous Thioamide Into a Thiophene Solution: Possibility 1: Sulfonium Ion Intermediate Solution: Possibility 2: Iminium Ion Intermediate Solution: Possibility 3 Key Steps Explained Additional Resources References Rearrangements During Synthetic Studies on Carba-Sugars Solution: (i) 23 With Triflic Anhydride Solution: (ii) Dihydroxylation Mechanism Balanced Chemical Equation: Dihydroxylation of 4 Solution: (ii) Formation of 6 Solution: (ii) Formation of 5 Key Steps Explained Additional Resources References A Pyrimidine to Pyrazole Transformation Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Attempted Diastereocontrol in Synthesis of a Homoallylic Alcohol Solution Key Steps Explained Additional Resources References Arsonium Ylides for Cyclopropane Synthesis Solution Alternate Possible Pathway Key Steps Explained Additional Resources References Pyridoacridines From 4-Quinolones Solution: 1 to 2 Balanced Chemical Equation: 12 Solution: F to 3 Balanced Chemical Equation: 13 Solution: CAN Oxidation of 24 Balanced Chemical Equation: 24 Solution: CAN Oxidation of 34 Balanced Chemical Equation: 34 Additional Resources References Further Reading Imidoyl Radicals in a New Quinoline Synthesis Solution-1 to B Solution-B to 2 Solution-B to 3 Key Steps Explained Additional Resources References Electrolytic Fluorinative Ring Expansion Reactions Solution Key Steps Explained Additional Resources References An Isoxazole to 1,3-Oxazine Transformation Key Steps Explained Solution: 3-Phenyl-5-isoxazolone 1 Solution: 1 2 Additional Resources References Synthesis of Folate Antimetabolites: A Furan to Pyrrole Transformation Solution: Mechanism A Solution: Mechanism B Balanced Chemical Equation (Applies to Both Mechanism A and B) Key Steps Explained Additional Resources References Rearrangement of a Silylacetylenic Ketone Solution Key Steps Explained Additional Resources References And More Silyl Rearrangements: A Brook-Retro-Brook Sequence Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Two Syntheses of Dehydrorotenone Solution: (i) From 21 Balanced Chemical Equation for (i) Solution: (ii) From 3 and 42 Mechanism A Balanced Chemical Equation for Mechanism A Solution: (ii) From 3 and 42 Mechanism B Balanced Chemical Equation for Mechanism B Key Steps Explained Additional Resources References Radical-Induced Decarboxylation of a Lactone Solution: Pathway A Pathway B Key Steps Explained Additional Resources References Aryl Azide Thermolysis: ``A Series of Rather Involved Rearrangement Reactions´´ Solution Balanced Chemical Equation Key Steps Explained Balanced Chemical Equation Balanced Chemical Equation Additional Resources References An Efficient Route to Hexakis(trifluoromethyl)cyclopentadiene Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Exploitation of the Boulton-Katritzky Rearrangement: Synthesis of 4,4-Diamino-3,3-bifurazan Solution Additional Resources References Rearrangement During Hydrolysis of a Cyclohexadienone Solution: 12 Balanced Chemical Equation: 12 Solution: 23, 4 Balanced Chemical Equation: 13, 4 Key Steps Explained Additional Resources References Less Common Sigmatropic Rearrangements: [3,4], [3,5], or Even [2,3]? Solution: Thionation Mechanism Solution: A2 Balanced Chemical Equation: 12 Solution: B3 Balanced Chemical Equation: 13 Key Steps Explained Additional Resources References Failure to Construct an Oxetane by SN Rearrangement Solution Balanced Chemical Equation Key Steps Explained Additional Resources References Acid-Catalyzed Isomerization of a Tetraspiroketone Solution: 12 Solution: 13 Key Steps Explained Additional Resources References Index_2019_Strategies-and-Solutions-to-Advanced-Organic-Reaction-Mechanisms Index A B C D E F G H I J K L M N O P Q R S T U V W X Y Z