Stories of Success-Personal Recollections. XI

Comprehensive biochemistry......Page 1
Elsevier......Page 2
Preface to volume 46......Page 3
References......Page 5
Contributors to this volume......Page 6
Half a Century Later and, Still, I’m Not Disenchanted with Science......Page 8
Instead of a Preface......Page 9
My Parents......Page 10
Fate of the Family During the War, 1941-1945......Page 15
After the War. The ‘‘Doctor’s Plot.’’ The Death of Stalin......Page 28
School Life......Page 31
University: Student Community and Lysenko......Page 35
Linus Pauling Visits Moscow University......Page 45
The Engelhardt’s Institute: First Years......Page 46
A Digression from Biochemistry into the Physics of Biopolymers......Page 58
Macromolecular Structure of Transfer RNA in Solution......Page 60
Aminoacyl-tRNA Synthetases......Page 61
The Role of Anticodon in the Second Genetic Code......Page 63
IUB Congress in New York: The First Trip Abroad......Page 65
Visits to France, 1967 and 1974......Page 73
The Revertase Project: Deviation from the Mainstream......Page 80
Russian Version of the Human Genome Project......Page 82
Paris Once More hellip......Page 84
Termination Translation in Eukaryotes: Last Love?......Page 88
Human Frontiers Science Program: Intercontinental Cooperation......Page 98
Editorial Activities......Page 99
Scientific Research as a Source of Optimism......Page 101
Acknowledgments......Page 106
Russian journals Biokhimiya and Molekularnaya Biologiya are available in English. Although the volumes and years coincide in both versions, the page numbers differ. Here they are given for Russian edition if not specified otherwise.......Page 107
A Farewell......Page 120
The Pathway to the Institut Pasteur: Chance or Destiny......Page 121
The Pathway to Protein Folding......Page 144
A Detour Through Molecular Enzymology: The Catalytic Mechanism of Tryptophan Synthase......Page 152
Back and Deep into Protein Folding: The ‘‘Globule’’ Model......Page 165
Without Monsieur Monod: Globules, Molten Globules, and the Tryptophan Synthase Folding Pathway......Page 176
From Molten Globules to Pre-Molten Globules......Page 181
Probing the Conformation of Proteins and Folding Intermediates with Monoclonal Antibodies......Page 184
Analogies between the Folding Mechanisms of Tryptophan Synthase and other Proteins......Page 191
From Aggregates to Prions: Back to Early Concerns......Page 199
My Proteinless Studies......Page 215
Administration and Transmission of Science......Page 222
Concluding Remarks......Page 230
References......Page 233
Explosive Extracellular Matrix Research from 1960 to 2000. A Personal Recollection of the Work Pioneered by Rupert Timpl......Page 237
Biographical Notes......Page 238
Training in Chemistry and First Contacts with Biology......Page 241
The State of the Art of Matrix Research in the 1960s......Page 243
From Immunology to the Complexity and Structure of the Extracellular Matrix......Page 245
The Basement Membrane Proteins Collagen IV and the Discovery of Laminin......Page 249
Discovery of Laminin’s Cell Biological Activities......Page 252
Basement Membrane Proteoglycans......Page 254
Nidogen/Entactin, Collagen VI, and BM-40/SPARC......Page 255
Ringberg and Other Meetings......Page 257
Domains and Interacting Proteins at Atomic Resolution......Page 260
Promotion to Scientific Member of the Max-Planck-Society and the arrival of Takako Sasaki......Page 262
Cellular Receptors for Matrix Proteins......Page 265
Collagen XVIII and Endostatin......Page 266
The Last Years......Page 268
The Memorial Symposium, a Summary and Outlook......Page 270
References......Page 274
A Life with Yeast Molecular Biology......Page 280
My Early Years and Education......Page 281
Institute of Genetics and tRNA......Page 290
Institute of Physiological Chemistry in Munich tRNA Biogenesis......Page 296
Yeast tRNA Genes and Ty Elements......Page 300
The Yeast Genome Project......Page 307
Yeast 26S Proteasome and Triple A Proteins......Page 310
Administration and Teaching Medical Students......Page 313
FEBS......Page 314
Spetses Summer Schools......Page 320
Gene Technology......Page 322
Sonderforschungsbereich 190......Page 324
Other Encounters......Page 325
Epilogue......Page 326
Acknowledgment......Page 328
References......Page 329
A Botanist Going Astray: 77 Semesters of Studying Membrane Transport and Protein Glycosylation......Page 339
Youth and Eight Semesters of Studies in Munich......Page 340
My PhD Work at Purdue University......Page 343
Back in Munich: ‘‘Wissenschaftlicher Assistent’’ and Finding my Own Way......Page 344
University/German Science Advisory Board/DFG......Page 350
The Dichotomy of Basic Science in Germany: Universities Versus Max-Planck Institutes......Page 355
My Excursion into Real Botany......Page 358
An Inducible Active Transport System in a Eukaryotic Cell......Page 363
The Membrane Potential......Page 368
Transport Kinetics plus/minus Protons......Page 369
Can the Transport Protein also Act as a Facilitator?......Page 372
Cloning the Gene Coding for the Hexose Uptake Protein (HUP1)......Page 373
Structure/Function Relationships in HUP1......Page 374
In vitro Transport Tests and HUP1 Protein Purification......Page 375
Over 40 Years of Membrane Transport Proteins: How about the Role of Lipids?......Page 377
Rafts or Raft Clusters or a New Type of Plasma Membrane Micro-Domains......Page 379
Biochemistry and Molecular Biology......Page 381
Functional Aspects of Protein Glycosylation......Page 387
Balance Sheet and Outlook......Page 390
References......Page 391
Viktor Mutt: A Giant in the Field of Bioactive Peptides......Page 401
Early Days......Page 402
Secretin......Page 406
The Post-Secretin Period......Page 409
Viktor: Teacher, Scientist, and Friend......Page 412
Conclusions......Page 416
References......Page 417
Sailing Side by Side......Page 421
BMJ and HJ: About this Chapter......Page 422
HJ: Growing Up in the Orbit of Chemistry......Page 423
BMJ: The Roots: Memories from an Uneventful Childhood......Page 427
HJ: Too Many Years of Lessons and Lectures......Page 428
BMJ: Education in Science......Page 432
HJ: Everybody Should have been to Tuumlbingen......Page 436
HJ: Ending Halfway up the Hill......Page 440
BMJ: A Munich-Tuumlbingen Connection......Page 441
HJ: In the Dungeons: From Phytopathology to Protein Stability......Page 442
BMJ: From Ant Lions to Pond Snails......Page 452
BMJ and HJ: From the East Coast to the Midwest, by Beetle......Page 455
HJ: ‘‘Harold from Biophysics’’......Page 459
BMJ: An Acellular Model of the Cancer Cell......Page 461
HJ and BMJ: Founding a Family in Good Old Tübingen......Page 463
HJ: From Virus to Mould......Page 464
BMJ: Would a Slime Mould Thrive at Tuumlbingen?......Page 467
HJ: ‘‘hellip zum Städtele hinaus’’ - Leaving Tübingen for Good......Page 469
HJ: Changing Fields Again......Page 470
BMJ: From Slime Mould to Vertebrate Cells......Page 472
HJ: Down the Rhine: From Basel to Heidelberg......Page 474
HJ and BMJ: On the Move Again......Page 475
BMJ: A Step up the Hill: EMBL at Heidelberg......Page 476
HJ: Brain and Muscle......Page 480
BMJ and HJ: Settling the Family up North......Page 482
HJ: ‘‘Where is Bielefeld?’ - From Mouse to Man......Page 484
BMJ: Making the Best of it: Bielefeld University......Page 495
HJ: Cytoskeletal Diseases of Muscle......Page 499
BMJ: The last Bielefeld Years: Research and Science Politics......Page 510
HJ: Genes, Chromosomes, and Sick Neurons......Page 516
BMJ: Greener Pastures in Lower Saxony......Page 525
HJ: The Resurrection of TMV......Page 526
BMJ: Research at the ‘‘Carolo Wilhelmina’’......Page 527
HJ: Morphogenesis and a Bit of Mathematics......Page 540
BMJ and HJ: Returning to Southern Germany......Page 543
HJ: Shop Closed, Business Continues......Page 544
BMJ: Closing the Circle......Page 546
HJ and BMJ: Special Places, Special People......Page 548
HJ and BMJ: A Privileged Life......Page 554
References......Page 555
Abbreviations and Symbols......Page 567
Technical Information Relating to HJ......Page 568
sdarticle_011.pdf......Page 569