Store-Operated Ca2+ Entry (SOCE) Pathways: Emerging Signaling Concepts in Human (Patho)physiology

Front Matter ....Pages i-xxix
Front Matter ....Pages 1-1
 Introduction  (James W. Putney)....Pages 3-13
 The STIM-Orai Pathway: STIM-Orai Structures: Isolated and in Complex  (Jinhui Zhu, Qingping Feng, Peter B. Stathopulos)....Pages 15-38
 The STIM-Orai Pathway: Orai, the Pore-Forming Subunit of the CRAC Channel  (Aparna Gudlur, Patrick G. Hogan)....Pages 39-57
 The STIM-Orai Pathway: The Interactions Between STIM and Orai  (Marc Fahrner, Rainer Schindl, Martin Muik, Isabella Derler, Christoph Romanin)....Pages 59-81
 The STIM-Orai Pathway: Conformational Coupling Between STIM and Orai in the Activation of Store-Operated Ca2+ Entry  (Robert M. Nwokonko, Xiangyu Cai, Natalia A. Loktionova, Youjun Wang, Yandong Zhou, Donald L. Gill)....Pages 83-98
 The STIM-Orai Pathway: Regulation of STIM and Orai by Thiol Modifications  (Barbara A. Niemeyer)....Pages 99-116
 The STIM-Orai Pathway: Light-Operated Ca2+ Entry Through Engineered CRAC Channels  (Guolin Ma, Shufan Wen, Yun Huang, Yubin Zhou)....Pages 117-138
 STIM-TRP Pathways and Microdomain Organization: Ca2+ Influx Channels: The Orai-STIM1-TRPC Complexes  (Dora Bodnar, Woo Young Chung, Dongki Yang, Jeong Hee Hong, Archana Jha, Shmuel Muallem)....Pages 139-157
 STIM-TRP Pathways and Microdomain Organization: Contribution of TRPC1 in Store-Operated Ca2+ Entry: Impact on Ca2+ Signaling and Cell Function  (Hwei Ling Ong, Indu S. Ambudkar)....Pages 159-188
 STIM-TRP Pathways and Microdomain Organization: Auxiliary Proteins of the STIM/Orai Complex  (Jonathan Pacheco, Luis Vaca)....Pages 189-210
Front Matter ....Pages 211-211
 Introduction  (Alexei V. Tepikin)....Pages 213-216
 New Aspects of the Contribution of ER to SOCE Regulation: The Role of the ER and ER-Plasma Membrane Junctions in the Regulation of SOCE  (Hayley Dingsdale, Emmanuel Okeke, Lee Haynes, Gyorgy Lur, Alexei V. Tepikin)....Pages 217-237
 New Aspects of the Contribution of ER to SOCE Regulation: TRPC Proteins as a Link Between Plasma Membrane Ion Transport and Intracellular Ca2+ Stores  (Alexis Bavencoffe, Michael Xi Zhu, Jin-bin Tian)....Pages 239-255
 The Role of Mitochondria in the Activation/Maintenance of SOCE: Store-Operated Ca2+ Entry and Mitochondria  (András Spät, Gergö Szanda)....Pages 257-275
 The Role of Mitochondria in the Activation/Maintenance of SOCE: Membrane Contact Sites as Signaling Hubs Sustaining Store-Operated Ca2+ Entry  (Nicolas Demaurex, Daniele Guido)....Pages 277-296
 The Role of Mitochondria in the Activation/Maintenance of SOCE: The Contribution of Mitochondrial Ca2+ Uptake, Mitochondrial Motility, and Location to Store-Operated Ca2+ Entry  (Roland Malli, Wolfgang F. Graier)....Pages 297-319
 Tissue Specificity: The Role of Organellar Membrane Nanojunctions in Smooth Muscle Ca2+ Signaling  (Nicola Fameli, A. Mark Evans, Cornelis van Breemen)....Pages 321-342
 Tissue Specificity: SOCE: Implications for Ca2+ Handling in Endothelial Cells  (Lothar A. Blatter)....Pages 343-361
 Tissue Specificity: Store-Operated Ca2+ Entry in Cardiac Myocytes  (Martin D. Bootman, Katja Rietdorf)....Pages 363-387
Front Matter ....Pages 389-389
 Introduction: Overview of the Pathophysiological Implications of Store-Operated Calcium Entry in Mammalian Cells  (Juan A. Rosado)....Pages 391-395
 Immunological Disorders: Regulation of Ca2+ Signaling in T Lymphocytes  (Sonal Srikanth, Jin Seok Woo, Zuoming Sun, Yousang Gwack)....Pages 397-424
 Cardiovascular and Hemostatic Disorders: Role of STIM and Orai Proteins in Vascular Disorders  (Jyoti Tanwar, Mohamed Trebak, Rajender K. Motiani)....Pages 425-452
 Cardiovascular and Hemostatic Disorders: SOCE and Ca2+ Handling in Platelet Dysfunction  (Jose J. Lopez, Gines M. Salido, Juan A. Rosado)....Pages 453-472
 Cardiovascular and Hemostatic Disorders: SOCE in Cardiovascular Cells: Emerging Targets for Therapeutic Intervention  (Klaus Groschner, Niroj Shrestha, Nicola Fameli)....Pages 473-503
 Cardiac Remodeling and Disease: SOCE and TRPC Signaling in Cardiac Pathology  (Petra Eder)....Pages 505-521
 Cardiac Remodeling and Disease: Current Understanding of STIM1/Orai1-Mediated Store-Operated Ca2+ Entry in Cardiac Function and Pathology  (Fiona Bartoli, Jessica Sabourin)....Pages 523-534
 Neurological and Motor Disorders: Neuronal Store-Operated Ca2+ Signaling: An Overview and Its Function  (Sunitha Bollimuntha, Biswaranjan Pani, Brij B. Singh)....Pages 535-556
 Neurological and Motor Disorders: TRPC in the Skeletal Muscle  (Sophie Saüc, Maud Frieden)....Pages 557-575
 Fertility: Store-Operated Ca2+ Entry in Germ Cells: Role in Egg Activation  (Zoltan Machaty, Chunmin Wang, Kiho Lee, Lu Zhang)....Pages 577-593
 Metabolic Disorders and Cancer: Hepatocyte Store-Operated Ca2+ Channels in Nonalcoholic Fatty Liver Disease  (Eunüs S. Ali, Grigori Y. Rychkov, Greg J. Barritt)....Pages 595-621
 Metabolic Disorders and Cancer: Store-Operated Ca2+ Entry in Cancer: Focus on IP3R-Mediated Ca2+ Release from Intracellular Stores and Its Role in Migration and Invasion  (Abigaël Ritaine, George Shapovalov, Natalia Prevarskaya)....Pages 623-637
Back Matter ....Pages 639-645