Stable Nanoemulsions: Self-Assembly in Nature and Nanomedicine

Content: 
Copyright
Page iv

Dedication
Page v

Preface
Pages vii-ix
Joseph S. D\'Arrigo

Chapter 1 - Occurrence of Dilute Gas-in-Liquid Emulsions in Natural Waters
Pages 3-28
Joseph D\'Arrigo

Chapter 2 - Early Work with Aqueous Carbohydrate Gels
Pages 29-44
Joseph D\'Arrigo

Chapter 3 - Comparison of Aqueous Soil Extracts with Carbohydrate Gels
Pages 45-54
Joseph D\'Arrigo

Chapter 4 - Characteristic Glycopeptide Fraction of Natural Microbubble Surfactant
Pages 55-80
Joseph D\'Arrigo

Chapter 5 - Ecological Chemistry of Microbubble Surfactant
Pages 83-95
Joseph D\'Arrigo

Chapter 6 - Surface Properties of Microbubble-Surfactant Monolayers
Pages 97-106
Joseph D\'Arrigo

Chapter 7 - Structure of Predominant Surfactant Components Stabilizing Natural Microbubbles
Pages 107-112
Joseph D\'Arrigo

Chapter 8 - Stable Microbubbles in Physiological Fluids: Competing Hypotheses
Pages 113-123
Joseph D\'Arrigo

Chapter 9 - Concentrated Gas-in-Liquid Emulsions in Artificial Media. I. Demonstration by Laser-Light Scattering
Pages 127-133
Joseph D\'Arrigo

Chapter 10 - Concentrated Gas-in-Liquid Emulsions in Artificial Media. II. Characterization by Photon Correlation Spectroscopy
Pages 135-168
Joseph D\'Arrigo

Chapter 11 - Concentrated Gas-in-Liquid Emulsions in Artificial Media. III. Review of Molecular Mechanisms Involved in Microbubble Stabilization
Pages 169-173
Joseph D\'Arrigo

Chapter 12 - Targeted Imaging of Tumors, and Targeted Cavitation Therapy, with Lipid-Coated Microbubbles (LCM)
Pages 177-187
Joseph D\'Arrigo

Chapter 13 - Targeted Drug-Delivery Therapy of Tumors Using LCM
Pages 189-205
Joseph D\'Arrigo

Chapter 14 - Proposed Mechanism of Selective LCM Uptake by Tumor Cells: Role of Lipoprotein Receptor-Mediated Endocytic Pathways
Pages 207-216
Joseph D\'Arrigo

Chapter 15 - Endocytotic Events Versus Particle Size: Multidisciplinary Analyses Demonstrate LCM Sizes are Mostly Submicron
Pages 217-220
Joseph D\'Arrigo

Chapter 16 - LCM and Nanoparticle Subpopulations for Drug Delivery
Pages 223-228
Joseph D\'Arrigo

Chapter 17 - Composition of LCM Governing Interplay with Nanoparticle Subpopulation
Pages 229-234
Joseph D\'Arrigo

Chapter 18 - Targeted Nanoparticle Subpopulation: Comparison with Self-Nanoemulsifying Drug-Delivery Systems in Pharmaceutical Research
Pages 235-238
Joseph D\'Arrigo

Chapter 19 - Clinical Development of an “LCM/Nanoparticle-Derived” Formulation: A Nanoemulsion Based Upon “Dispersed LMN”
Pages 239-246
Joseph D\'Arrigo

Chapter 20 - Selected Parenteral Lipid Nanoemulsions Under Clinical Study: Comparison Concerning Passive Accumulation in Tumors, Active Targeting of Tumors, and Validation Status
Pages 247-254
Joseph D\'Arrigo

Chapter 21 - Supplementary Operational Benefits Concerning “LCM/Nanoparticle-Derived” Formulations: Relation to Lipid-Nanoemulsion Structure
Pages 255-263
Joseph D\'Arrigo

Chapter 22 - Biological Lipid Polymorphs: Preferred Cubic Phase of “Dispersed LMN”
Pages 267-276
Joseph D\'Arrigo

Chapter 23 - Nonlamellar Phase(s) Facilitating Membrane Fusion: Endocytosis of Dispersed LMN
Pages 277-286
Joseph D\'Arrigo

Chapter 24 - Receptor-Mediated Endocytosis of (Mixed-Lipid) Dispersed LMN
Pages 287-303
Joseph D\'Arrigo

Chapter 25 - Further Chemotherapy with Lipid Nanoemulsions: Targeting Certain Hyperproliferative Diseases, as well as Neoplasias, via “Lipoprotein Receptor”-Mediated Endocytosis
Pages 305-321
Joseph D\'Arrigo

Chapter 26 - Related Clinical Trials and Human Epidemiological Studies
Pages 323-332
Joseph D\'Arrigo

Chapter 27 - Aspects of Future R&D Regarding Targeted Lipid Nanoemulsions
Pages 333-342
Joseph D\'Arrigo

Subject Index
Pages 411-415