Specificity and Function of Clonally Developing T Cells

Front Matter....Pages I-XV
Front Matter....Pages 1-1
Introductory Remarks....Pages 3-4
Development of T Lymphocytes Within the Thymus and Within Thymic Nurse Cells....Pages 5-18
Thymus Development....Pages 19-25
Major Histocompatibility-Restricted Cytolytic T-Lymphocyte Precursors from the Thymus of In Vivo Primed Mice: Increased Frequency and Resistance to Anti-Lyt-2 Antibody Inhibition....Pages 27-33
Thymic Stem Cells: Their Interaction with the Thymic Stroma and Tolerance Induction....Pages 35-41
Front Matter....Pages 43-43
Organization, Rearrangement, and Diversification of Mouse T-Cell Receptor Genes....Pages 45-51
Expression of T-Cell Receptor by a Mouse Monoclonal Antigen-Specific Suppressor T-Cell Line....Pages 53-61
Somatic Variation of Antigen-Recognition Specificity in H-2 b -TNP-Specific Cytotoxic T-Cell Clones....Pages 63-67
The Change of Specificity, Karyotype, and Antigen-Receptor Gene Expression is Correlated in Cytotoxic T-Cell Lines....Pages 69-74
Front Matter....Pages 75-75
Introductory Remarks....Pages 77-78
A Study of the Functional Potential of Mouse T-Cell Clones....Pages 79-91
Generation, Propagation, and Variation in Cloned, Antigen-Specific, Ia-Restricted Cytolytic T-Cell Lines....Pages 93-100
Significance of T4 or T8 Phenotype of Human Cytotoxic T-Lymphocyte Clones....Pages 101-109
Natural and Unnatural Killing by Cytolytic T Lymphocytes....Pages 111-119
Acquisition of Suppressive and Natural Killer-Like Activities Associated with Loss of Alloreactivity in Human “Helper” T-Lymphocyte Clones....Pages 121-130
Expression and Function of Class II I-A k Antigens on an Antigen-Specific T-Suppressor Cell Clone....Pages 131-140
Front Matter....Pages 139-139
Introductory Remarks....Pages 141-142
Heterogeneity of the Signal Requirements During the Primary Activation of Resting Lyt-2 + Cytotoxic T-Lymphocyte (CTL) Precursors into Clonally Developing CTL....Pages 143-153
Regulation of Lytic Function by Recombinant IL2 and Antigen....Pages 155-164
The Target Structure for T11: A Cell Interaction Molecule Involved in T-Cell Activation?....Pages 165-172
Front Matter....Pages 139-139
Antigen- and Lectin-Sensitized Murine Cytolytic T Lymphocyte-Precursors Require Both Interleukin 2 and Endogenously Produced Immune (γ) Interferon for Their Growth and Differentiation into Effector Cells....Pages 173-185
Activation Requirements for Resting T Lymphocytes....Pages 187-194
Front Matter....Pages 195-195
Introductory Remarks....Pages 197-198
Functional Clonal Deletion and Suppression as Complementary Mechanisms in T Lymphocyte Tolerance....Pages 199-205
Human T Cell Clones, Tolerance, and the Analysis of Autoimmunity....Pages 207-211
Antiself Suppressive (Veto) Activity of Responder Cells in Mixed Lymphocyte Cultures....Pages 213-223
Analysis of T Suppressor Cell Mediated Tumor Escape Mechanisms....Pages 225-230
The T-Cell Receptor Recognizes Nominal and Self Antigen Independently. A Theoretical Alternative to the Modified Self Concept....Pages 231-238
Front Matter....Pages 239-239
Introductory Remarks....Pages 241-242
T-Cell Reactivity to Polymorphic MHC Determinants I. MHC-Guided T-Cell Reactivity....Pages 243-257
T-Cell Reactivity to Polymorphic MHC Determinants II. Self-reactive and Self-restricted T Cells....Pages 259-274
T-Cell Reactivity to Polymorphic MHC Determinants III. Alloreactive and Allorestricted T Cells....Pages 275-289
Appearance of New Specificities in Lectin-Induced T-Cell Clones Obtained from Limiting Dilution T-Cell Cultures....Pages 291-299
Syngeneic Cytotoxicity and Veto Activity in Thymic Lymphoid Colonies and Their Expanded Progeny....Pages 301-309
Functional Analysis of a Self-I-A Reactive T-Cell Clone Which Preferentially Stimulates Activated B Cells....Pages 311-316