Special Focus on the Biology of Aging

Front Matter....Pages i-xiii
Overview of Biological Mechanism of Aging....Pages 1-22
Genetic Diseases of Premature Aging as Models of Senescence....Pages 23-42
Growth Factors and Cell Aging....Pages 43-52
Role of Endogenous Proteins as Negative Growth Modulators During In Vitro Cellular Aging of Human Diploid Fibroblasts....Pages 53-70
T-Cell Function in Aging: Mechanisms of Decline....Pages 71-96
Molecular Genetic Approaches to Mechanisms of Senescence....Pages 97-116
Altered Protein Metabolism in Aging....Pages 117-131
Mechanisms of Altered Hormone-Neurotransmitter Action During Aging: From Receptors to Calcium Mobilization....Pages 132-146
Skeletal Muscle Weakness and Fatigue in Old Age: Underlying Mechanisms....Pages 147-166
Vulnerability of the Neuronal Cytoskeleton in Aging and Alzheimer Disease: Widespread Involvement of All Three Major Filament Systems....Pages 167-182
Dietary Restriction as a Probe of Mechanisms of Senescence....Pages 183-197
Role of Free Radicals in Senescence....Pages 198-213
Back Matter....Pages 215-225