SOURCEBOOK OF MODELS FOR BIOMEDICAL RESEARCH

Front Matter....Pages i-xvi
Front Matter....Pages 1-1
Animal Models for Human Diseases....Pages 3-8
Selection of Biomedical Animal Models....Pages 9-15
Improved Models for Animal Research....Pages 17-24
Front Matter....Pages 25-25
The Ethical Basis for Animal Use in Research....Pages 27-33
Bibliographic Searching Tools on Disease Models to Locate Alternatives for Animals in Research....Pages 35-41
NIH Policies on Sharing of Model Organisms and Related Research Resources....Pages 43-48
Databases for Biomedical Animal Resources....Pages 49-54
Psychological Enrichment for Animals in Captivity....Pages 55-63
Front Matter....Pages 65-65
Integrated Network Modeling of Molecular and Genetic Interactions....Pages 67-74
The Sponge as a Model of Cellular Recognition....Pages 75-83
Sea Urchin Embryo....Pages 85-90
 Caenorhabditis elegans Models of Human Neurodegenerative Diseases....Pages 91-101
Zebrafish as a Model for Development....Pages 103-112
Zebrafish as a Model for Studying Adult Effects of Challenges to the Embryonic Nervous System....Pages 113-120
Modeling Cognitive and Neurodegenerative Disorders in Drosophila melanogaster ....Pages 121-128
Biomedical Research with Honey Bees....Pages 129-138
Establishing and Maintaining a Xenopus laevis Colony for Research Laboratories....Pages 139-160
The Chicken as a Model Organism....Pages 161-167
Rat Knockout and Mutant Models....Pages 171-178
Rodent Genetics, Models, and Genotyping Methods....Pages 179-186
Front Matter....Pages 65-65
The House Mouse in Biomedical Research....Pages 187-190
Mouse Model for Alzheimer’s Disease....Pages 191-199
Guinea Pigs as Models for Human Cholesterol and Lipoprotein Metabolism....Pages 201-212
Reliability of Rodent Models....Pages 213-217
The Domestic Cat, Felis catus , as a Model of Hereditary and Infectious Disease....Pages 221-232
Swine in Biomedical Research....Pages 233-239
The Minipig as an Animal Model in Biomedical Stem Cell Research....Pages 241-248
The Nonhuman Primate as a Model for Biomedical Research....Pages 251-258
Primates as Models of Behavior in Biomedical Research....Pages 259-266
Primate Models for Understanding Brain Mechanisms of Cognitive Behavior....Pages 267-276
Front Matter....Pages 277-277
Animal Models for Eye Diseases and Therapeutics....Pages 279-287
Animal Models of Noise-Induced Hearing Loss....Pages 289-301
Human and Animal Models for the Study of Muscle Pain....Pages 305-312
Animal Models of Parkinson’s Disease....Pages 313-322
Transgenic Animal Models of Neurodegenerative Diseases....Pages 323-331
Animal Models of Nociception and Pain....Pages 333-339
Nonmammalian Models for the Study of Pain....Pages 341-352
Front Matter....Pages 353-353
Animal Models of Vascular Development and Endothelial Cell Biology....Pages 355-360
Models of Behavior....Pages 361-368
Animal Models for Atherosclerosis, Restenosis, and Endovascular Aneurysm Repair....Pages 369-384
Front Matter....Pages 353-353
Rat Models of Experimental Autoimmune Encephalomyelitis....Pages 547-556
Animal Models in Virology....Pages 557-563
Nonhuman Primate Models for AIDS....Pages 565-572
Primate Models for the Assisted Reproductive Technologies and Embryonic Stem Cell Biology....Pages 397-404
Rat Models of Polycystic Ovary Syndrome....Pages 405-410
Murine Models for Reproduction....Pages 411-423
Pig Model to Study Dynamics of Steroids During Ovarian Follicular Growth and Maturation....Pages 425-436
Gene Targeting in Human Somatic Cells....Pages 509-525
Animal Models for Investigating the Causes and Mechanisms of Mammalian Germ Cell Aneuploidy....Pages 527-537
Genetic Models of Alzheimer’s Disease....Pages 539-544
Molecular Genetic Approach to Identify Inhibitors of Signal Transduction Pathways....Pages 439-443
Yeast as a Model System to Study DNA Damage and DNA Repair....Pages 445-453
Human Models of Space Physiology....Pages 457-464
Developmental Space Biology of Mammals....Pages 465-472
A Practical Approach to Animal Models of Sepsis....Pages 473-482
Animal Models in Functional Magnetic Resonance Imaging....Pages 483-498
Animal Models in Aging Research....Pages 499-506
Transgenic mouse models of HIV-1/AIDS and cardiac performance....Pages 385-393
Front Matter....Pages 573-573
Use of Congenic Mouse Strains for Candidate Disease Gene Identification in Complex Traits....Pages 575-581
Animal Models of Sudden Infant Death Syndrome....Pages 583-590
Front Matter....Pages 573-573
Animal Models of Posttraumatic Stress Disorder....Pages 591-601
Animal Models for Studying Fetal Alcohol Syndrome, Alcohol-Related Birth Defects, and Alcohol-Related Neurodevelopmental Disorder....Pages 603-614
Modeling Drug and Alcohol Abuse....Pages 615-622
Mouse Models for Experimental Cancer Therapy....Pages 623-629
Rat Models of Skin Wound Healing....Pages 631-638
Animal Models of Prostate Cancer....Pages 639-649
Animal Models of Diabetes....Pages 651-656
Animal Models of Kidney Diseases....Pages 657-664
Animal Models of Multiple Sclerosis....Pages 665-676
Canine and Feline Models for Cancer....Pages 677-682
Obese Mouse Models....Pages 683-702
Study of Polycystic Kidney Disease in the Nematode Caenorhabditis elegans ....Pages 703-711
Animal Models of Myelofibrosis....Pages 713-723
Animal Models for Bone Tissue Engineering Purposes....Pages 725-736
Front Matter....Pages 737-737
Markov Processes for Biomedical Data Analysis....Pages 739-745
Software Tools for Modeling Biomedical Systems....Pages 747-752
Developing Websites for Biomedical Research and Training....Pages 753-757
Building Virtual Research Communities Using Web Technology....Pages 759-762
Back Matter....Pages 763-778