Small Animal Imaging: Basics and Practical Guide

Front Matter....Pages i-xix
Front Matter....Pages 1-1
Noninvasive Imaging for Supporting Basic Research....Pages 3-32
Non-invasive Imaging in the Pharmaceutical Industry....Pages 33-46
Designing a Small Animal Imaging Center....Pages 47-67
Noninvasive Small Rodent Imaging: Significance for the 3R Principles....Pages 69-87
Front Matter....Pages 89-89
Institutional Preconditions for Small Animal Imaging....Pages 91-99
Statistical Considerations for Animal Imaging Studies....Pages 101-116
Anesthesia and Analgesia in Laboratory Animals....Pages 117-126
Drug Administration....Pages 127-152
Front Matter....Pages 153-153
How to Choose the Right Imaging Modality....Pages 155-161
How to Identify Suitable Molecular Imaging Biomarkers....Pages 163-176
Concepts in Diagnostic Probe Design....Pages 177-200
X-Ray and X-Ray-CT....Pages 201-225
MRI....Pages 227-324
Ultrasound....Pages 325-360
PET and SPECT....Pages 361-402
Optical Imaging....Pages 403-490
Multimodal Imaging and Image Fusion....Pages 491-507
Front Matter....Pages 509-509
In Vitro Methods for In Vivo Quantitation of PET and SPECT Imaging Probes: Autoradiography and Gamma Counting....Pages 511-525
Front Matter....Pages 527-527
Qualitative and Quantitative Data Analysis....Pages 529-545
Guidelines for Nuclear Image Analysis....Pages 547-557
Front Matter....Pages 527-527
Kinetic Modeling....Pages 559-580
Data Management in Small Animal Imaging: Conceptual and Technical Considerations....Pages 581-590
Front Matter....Pages 591-591
Cell Tracking and Transplant Imaging....Pages 593-603
Beta Cell Imaging as Part of “Imaging on Metabolic Diseases”....Pages 605-625
In Vivo Preclinical Imaging of Developmental Biology....Pages 627-650
Imaging in Gynecology Research....Pages 651-662
Imaging in Cardiovascular Research....Pages 663-688
Imaging in Neurooncology....Pages 689-725
Imaging in Neurology Research II: Exploring Plasticity and Cognitive Networks by In Vivo MRI....Pages 727-760
Imaging in Neurology Research III: Neurodegenerative Diseases....Pages 761-772
When Photons Meet Protons: Optogenetics, Calcium Signal Detection, and fMRI in Small Animals....Pages 773-791
Imaging in Oncology Research....Pages 793-819
PET Imaging in Immunology....Pages 821-844
Molecular Imaging of Infectious Diseases....Pages 845-856
Back Matter....Pages 857-875