Skin lipids

Content: Front Cover
 Skin Lipids
 Copyright Page
 Table of Contents
 PREFACE
 Chapter 1. Structural and Lipid Biochemical Correlates of the Epidermal PermeabilityBarrier
 I. Introduction and Historical Perspective
 II. Stratum Corneum Two-Compartment Model
 III. Cellular Basis for Lipid-Protein Sequestration in the StratumCorneum of Terrestrial Mammals
 IV. Insights from Aves and Marine Mammals (Cetaceans)
 V. Intercellular Membrane Structures in Mammalian Stratum Corneum
 VI. Structural Alterations in Pathological Stratum Corneum
 VII. Structural-LipidBiochemical Correlates
 VIII. Summary. ACKNOWLEDGMENTSReferences
 Chapter 2. The Biochemistry and Function of Stratum Corneum Lipids
 I. Introduction
 II. Historical Overview
 III. Biochemistry and Function
 IV. Essential Fatty Acid Metabolism
 V. Fatty Acid Uptake and Binding
 References
 Chapter 3. The Regulation and Role of Epidermal Lipid Synthesis
 I. Introduction
 II. Methodological Considerations
 III. Lipid Synthesis in the Skin
 IV. Systemic Regulation of Epidermal Lipid Synthesis
 V. Local Regulationof Epidermal Lipid Synthesis-Role of the Barrier
 VI. Importance of Epidermal Lipid Synthesis for Barrier Repair. VII. Signals Initiating Barrier RepairVIII. Local Regulation of Epidermal Lipid Synthesis-Potential Role of CellProliferation
 IX. Summary
 References
 Chapter 4. Lipid Metabolism in Cultured Keratinocytes
 I. Introduction
 II. Changes in LDL Receptor Expression and in Regulation of CholesterolSynthesis in Relation to Keratinocyte Differentiation
 III. Differentiation-Linked Changes in the Rate of Lipid Synthesis: Effect of Extracellular Lipoproteins
 IV. Differentiation-Linked Modulations of Keratinocyte Lipid Composition. V. Changes in the Plasma Membrane Lipid Composition and Fluidity in Relation to Keratinocyte DifferentiationVI. Retinoid-Induced Modulations of Lipid Composition in Cultured Keratinocytes
 VII. Conclusion
 VIII. Appendix
 ACKNOWLEDGMENTS
 References
 Chapter 5. Lipid Modulators of Epidermal Proliferation and Differentiation
 I. Introduction
 II. Ether Phospholipids: Platelet-Activating Factor
 III. Phospholipase-Initiated Signaling Mechanisms
 IV. Sphingolipids as Effector Molecules
 V. Miscellaneous Lipid Effectors
 VI. Summary
 References. Chapter 6. X-Ray Diffraction and Electron Paramagnetic Resonance Spectroscopy of Mammalian Stratum Corneum Lipid DomainsI. Introduction
 II. X-Ray Diffraction
 III. Electron Paramagnetic Resonance
 IV. Conclusions
 ACKNOWLEDGMENTS
 References
 Chapter 7. Strategies to Enhance Permeability via Stratum Corneum Lipid Pathways
 I. Introduction
 II. In Vitro Studies
 III. In Vivo Studies: Use of Attenuated Total ReflectanceInfrared Spectroscopy to Evaluate the SC
 IV. Conclusion
 ACKNOWLEDGMENTS
 References
 Chapter 8. Lipids in Normal and Pathological Desquamation
 I. Introduction.