Skin Cancer and UV Radiation

Front Matter....Pages I-XLII
Front Matter....Pages 1-1
Sun and Man: An Ambivalent Relationship in the History of Medicine....Pages 3-12
History of Therapeutic UV Radiation....Pages 13-19
History of Skin Cancer....Pages 20-27
Front Matter....Pages 29-29
Basic Physical Aspects of Environmental UV Radiation....Pages 31-36
UV Prognosis and UV Index Services in Europe....Pages 37-49
Ozone Holes and UV-Radiation: Ecological Consequences for Plants....Pages 50-58
Public On-Line Information on Solar UV Irradiance Based on Spectrometric Measurements in a Sea Resort....Pages 59-64
UV-Expert: A Spectroradiometric System for Individual UV Dosimetry....Pages 65-73
Front Matter....Pages 75-75
Basic Aspects of Collagen Metabolism....Pages 77-93
Sunburn and Apoptosis....Pages 94-101
Dermal Elimination of Apoptotic and Vital Melanocytes After UVA1 Radiation....Pages 102-108
 Importance of Calcium-Magnesium Antagonism and Thiols for Diminution of UVA 1 -Induced Cell Damage....Pages 109-114
Molecular Role of Reactive Oxygen Species in Photoaging and Tumor Progression....Pages 115-127
How Much Sun Do We Need to Produce Vitamin D?....Pages 128-130
UV-Radiation and Urocanic Acid....Pages 131-136
Activation of Human Endogenous Retroviral Sequences by UVB....Pages 137-147
Melanins and Related Metabolites in Skin Photoprotection....Pages 148-157
Physiology of Skin Pigmentation: Recent Results....Pages 158-163
Time Course of UV Erythema....Pages 164-168
Measurement of Constitutive Skin Phototypes....Pages 169-180
Front Matter....Pages 75-75
Photoprotection by Total Melanin Content and Pigment Phenotype (Eumelanin, Pheomelanin) in Human Melanoma Cell Lines....Pages 181-185
Melatonin: Multiple Functions in Signaling and Protection....Pages 186-198
Principles of Phototesting and Photopatch Testing....Pages 199-204
Optics of Human Skin: UV Effects Investigated with Dye Lasers....Pages 205-210
Quantitative Evaluation of the UV Reaction at 325 nm with a Two-Dimensional Laser Doppler Perfusion Imager....Pages 211-218
UV Radiation and Cytokines....Pages 219-226
Effect of UV Light on the Production of Proopiomelanocortin- Derived Peptides and Melanocortin Receptors in the Skin....Pages 227-237
Cytokines, Cytokine Receptors and Cytokine Antibodies: Clinical Implications....Pages 238-248
Mexoryl SX Protects Against Photoimmunosuppression....Pages 249-262
Front Matter....Pages 263-263
The Evolution of Recent Sunscreen....Pages 265-275
Sunscreens in Europe: Recent Developments....Pages 276-295
UV Protection by Sunscreens....Pages 296-313
Photostable Suncare Products: Major Progress in Sun Protection....Pages 314-319
Evaluation of Sunscreens....Pages 320-324
Regulations on Sunscreens....Pages 325-332
Use and Misuse of Sunscreens....Pages 333-342
Sunscreens in Melanoma Protection - Pros and Cons....Pages 343-356
Influence of Sunscreen on the Spectral Energy Distribution of Ultraviolet Radiation in Human Skin....Pages 357-362
Clothing as a Protection Against the Sun....Pages 363-373
Developing a United States Sun-Protective Clothing Standard....Pages 374-381
Front Matter....Pages 263-263
New UV Absorbers for Sun Protective Fabrics....Pages 382-387
Novel Approaches to Photoprotection....Pages 388-394
Betacarotene in the Prevention of Chronic Ultraviolet Damage and Non-melanoma Skin Cancer....Pages 395-402
Front Matter....Pages 403-403
Balneophototherapy....Pages 405-409
A New Psoralen-Containing Gel for Topical PUVA Therapy: Development and Treatment Results with Palmoplantar and Plaque-Type Psoriasis, Pustulosis Palmaris et Plantaris and Chronic/Hyperkeratotic Eczema....Pages 410-415
PUVA, Psoralens and Skin Cancer....Pages 416-424
PUVA Bath Therapy: A Therapeutic Alternative to Systemic Photochemotherapy....Pages 425-429
Artificial Light Sources for Phototherapy....Pages 430-433
Trioxsalen Bath PUVA Does Not Increase the Risk of Squamous Cell Skin Carcinoma: A Joint Analysis of 1124 Swedish and Finnish Patients Followed Up for 10 Years....Pages 434-439
Photoaging and Other Side Effects Due to the Long-Term PUVA Therapy....Pages 440-441
Evaluation of Psoralen Plus Ultraviolet A Bath Therapy for Sclerosing Dermatoses by In vivo Measurement of Skin Elasticity Using Cutometer SEM 575....Pages 442-445
Kinetics of 8-Methoxypsoralen - Induced Skin Photosensitization in PUVA Bath Photochemotherapy....Pages 446-449
8-Methoxypsoralen Plasma Levels in Patients with Different Dermatoses Following PUVA Bath Photochemotherapy....Pages 450-454
A New Treatment Modality of Localized Scleroderma: Low-Dose UVA 1 Phototherapy....Pages 455-461
Influences of UV Radiation in the Therapy of Psoriasis Vulgaris....Pages 462-468
Assessment of Actinic Elastosis by 20-MHz Sonography....Pages 469-476
Photopheresis as a Therapeutical Alternative for PUVA....Pages 477-483
Extracorporeal Photochemotherapy in the Treatment of Cutaneous T Cell Lymphoma....Pages 484-491
Modifications in Cutaneous Infiltrate and Death Rate of Lymphoid Cells in Mycosis Fungoides Patients Treated with Photopheresis....Pages 492-497
Front Matter....Pages 499-499
Future Trends in the Incidence of Cutaneous Malignant Melanoma in White Populations....Pages 501-506
Front Matter....Pages 499-499
Recent Epidemiological Trends of Cutaneous Melanoma in Germany, Austria and Switzerland. Results of the Central Malignant Melanoma Registry....Pages 507-518
Seasonal Patterns in the Diagnosis of Cutaneous Malignant Melanoma due to Differential Detection Rather than Biological Causes. An Analysis of the Data of the German Central Malignant Melanoma Registry....Pages 519-526
Parametric Estimation of the “Risk of Melanoma-Related Death” with the Recursion Formula of the Gompertz Survival Function....Pages 527-533
Nonmelanoma Skin Cancer Mortality....Pages 534-539
Basal and Squamous Cell Carcinoma: Sex, Age and Location Distribution....Pages 540-546
Meta-analysis of the Role of Oral Contraceptives in the Development of Malignant Melanoma Based on Published Case-Control Studies Revealed no Evidence for an Association....Pages 547-551
Demographic and Enviromental Factors Associated with Excess Risk for Malignant Melanoma and Non-melanocytic Skin Cancers in Alberta, Canada....Pages 552-558
Front Matter....Pages 559-559
Defining Individual Risk Factors for Skin Melanoma....Pages 561-570
Pregnancy, Nevi, and Melanoma....Pages 571-576
Allelic Loss and Skin Cancer....Pages 577-581
Cancer Prone Genophotodermatoses....Pages 582-588
Nevi and Initiation by Sun....Pages 589-594
Children and Sun....Pages 595-600
Skin Cancer Risks from Ultraviolet Lamps and Sunbeds....Pages 601-610
Artificial Light Sources and Skin Cancer: Definition of a Carcinogenic Action Spectrum....Pages 611-620
Efficiency of Therapeutic UV Devices and the Risk of Skin Cancer....Pages 621-631
Occupation and Skin Cancer....Pages 632-634
Skin Cancers in Organ Transplant Recipients....Pages 635-642
Malignant and Virus-Induced Skin Tumors in a 49-Year-Old Patient with a Heart Transplant....Pages 643-647
HIV Infection and Malignancies....Pages 648-677
Front Matter....Pages 559-559
Thermal Injury and UV Radiation as Cofactors in Scar-Associated Malignant Melanoma: Case Report and Review of the Literature....Pages 678-683
Naevi and Solar Keratoses as Risk Factors for Melanoma in Australia....Pages 684-687
Front Matter....Pages 689-689
Immunology of Melanoma....Pages 691-699
The Genetics of Actinic Keratoses....Pages 700-708
Multiple p53 Mutations are Common in Basal Cell Carcinoma....Pages 709-714
Nuclear Reactivity Relationship Among p53 and Some of its Downstream Proteins is Predictive of p53 Functional State....Pages 715-722
DNA Photodamage and its Repair in Human Epidermis In Vivo....Pages 723-726
UVB Irradiation, Mismatch Repair and Cutaneous Melanoma....Pages 727-737
Human Photoimmunology: The Relevance of Ultraviolet Radiation-Induced Immunosuppression for Photocarcinogenesis....Pages 738-743
The Induction of Nevi and Skin Tumors in Pigmented Hairless Mice (HRA, HRII-c/+SKH) by 9,10-Dimethyl-1,2-Benzanthracene and Ultraviolet Radiation....Pages 744-747
The Role of Human Papillomaviruses in Non-melanoma Skin Cancer....Pages 748-758
Presence of HPV DNA in Trichilemmomas Detected by Polymerase Chain Reaction....Pages 759-765
Immunhistology of Skin Cancer....Pages 766-776
Biochemical Cell Markers Used in Diagnosis of Spinous Cellular Carcinoma of the Lower Lip....Pages 777-785
Immunohistochemical Evaluation of Cell Cycle Regulating Proteins in Epithelial Skin Tumors....Pages 786-791
Front Matter....Pages 793-793
Skin Cancer Prevention....Pages 795-819
Do Not Give Skin Cancer A Chance....Pages 820-849
Worldwide Experience with the Realization of Educational Campaignes....Pages 850-856
Legislation of Skin Cancer Prevention in Europe....Pages 857-862
European Screening Projects: Experience in Germany....Pages 863-867
Front Matter....Pages 793-793
Addendum Campaign “Save your Skin”....Pages 868-875
Skin Cancer Prevention on Germany....Pages 876-883
The Activities of German Cancer Aid for the Prevention and Early Detection of Skin Cancer....Pages 884-888
Skin Cancer Prevention in North Rhine-Westphalia: How to Place the Message....Pages 889-894
Health and Fun: A Program for Preventive Care in Primary Schools....Pages 895-899
Primary prevention of Skin Cancer: A Model Conception in Cooperation with Schools and Kindergartens....Pages 900-901
Cost Effectiveness in Skin Cancers Prevention....Pages 902-908
Public Health Potential for Cancer Prevention in Europe....Pages 909-914
The Knowledge about Melanoma Risk Factors in the Public: Has it Changed for the Better?....Pages 915-919
Preventive Suggestions to Avoid Excessive Sunlight Exposure....Pages 920-922
The Improvement of Sun Protection Among Children: Empirical Evidence from Successive Studies in Göttingen....Pages 923-929
Multimedia Techniques in the Primary and Secondary Prevention of Malignant Melanoma....Pages 930-941
Statistical Methods for Evaluating the Efficacy of Screening Programs for Skin Cancer....Pages 942-954
Quality Assurance in Cancer Screening....Pages 955-963
General Guidelines for Quality Assurance of Skin Cancer Screening....Pages 964-967
Front Matter....Pages 969-969
Pitfalls in the Diagnosis of Pigmented Skin Tumors....Pages 971-992
Epiluminescence Microscopy: Diagnostic Standard....Pages 993-998
Differential Diagnosis of Skin Tumors Using Tumor Microcirculation....Pages 999-1006
High-Frequency Ultrasound of Skin Tumors....Pages 1007-1022
High-Frequency Ultrasound (50–150 MHz) in Dermatology....Pages 1023-1051
Front Matter....Pages 969-969
Computerised Diagnosis of Skin Cancer Using Neural Networks....Pages 1052-1063
Automated Instrumentation for the Diagnosis of Invasive Melanoma: Image Analysis of Oil Epiluminescence Microscopy....Pages 1064-1070
Noninvasive Bioengineering Techniques to Measure UV Effects in Human Skin....Pages 1071-1074
Influence of Two Minimal Erythema Doses on the Dermoscopic Image of Acquired Melanocytic Nevi....Pages 1075-1079
Instrumental Evaluation of Skin Colour and Melanoma Risk....Pages 1080-1085
Nevocellular Nevus, Malignant Melanoma, Basal Cell Carcinoma and Seborrheic Keratosis Can Be Differentiated Using Magnetic Resonance Microscopy....Pages 1086-1102
Skin Cancer Evaluation using Texture and Form Analysis of Sonograms....Pages 1103-1110
The Pre-operative Lympho-scintigraphy: Drainage Pathways and Variability in the Malignant Melanoma of the Trunc....Pages 1111-1119
Positron Emission Tomography: Evaluation of the Diagnostic Validity in Metastatic Melanoma....Pages 1120-1130
Tyrosinase Fails as an Early Melanoma Progression Marker....Pages 1131-1135
Evaluation of Serum Protein S-100 as a New Melanoma Marker....Pages 1136-1144
Single Dimensional Line Measurement with a Laser Sensor by Dynamic Focusing Principle as a Tool of Modern Skin Physiology....Pages 1145-1161
Telecommunication of Digitized Dermatoscopic Images Improves Histopathological Examination and Surgical Treatment of Skin Lesions....Pages 1162-1164
Front Matter....Pages 1165-1165
Recent Developments in Melanoma Surgery....Pages 1167-1173
Surgical Treatment of Non-Melanoma Skin Cancer....Pages 1174-1182
New Aspects in the Chemotherapy of Malignant Melanoma....Pages 1183-1188
The Sentinel Lymphonodectomy in the Treatment of Malignant Melanomas....Pages 1189-1197
Advances in the Adjuvant Therapy of Melanoma....Pages 1198-1199
Adjuvant Therapy for Malignant Melanoma....Pages 1200-1214
Active Immunotherapy in Melanoma Patients: New Experiences at National Cancer Institute of Milan....Pages 1215-1220
Front Matter....Pages 1165-1165
New Developments in (Chemo)Immunotherapy in the Management of Micrometastatic and Macrometastatic Melanoma....Pages 1221-1232
Follow-Up of Malignant Skin Tumors....Pages 1233-1241
Vaccination Against the Mouse B16 Melanoma: Irradiated Tumor Cells Mixed with Liposome-Encapsulated IL-2 as an Alternative to IL-2 Gene Transfected Tumor Cells....Pages 1242-1249
Fotemustine Monochemotherapy in Patients with Advanced Melanoma....Pages 1250-1255
Quality of Life and Pain Management of Terminal III Melanoma Patients: A Retrospective Study....Pages 1256-1264
Retinoids and Photocarcinogenesis: An End to the Controversy?....Pages 1265-1272
The Short-Term Use of 5-Fluorouracil to Identify Subclinical Actinic Keratoses in Young Adults with Subsequent Long-Term Application of Tretinoin to Prevent Tumor Progression....Pages 1273-1283
Improvement of the Therapy of Actinic Keratoses with 5-Fluorouracil: Clinical Results of a Treatment with a Low Dose Patch....Pages 1284-1287
Photodynamic Therapy of Skin Cancers: A New Therapeutic Alternative?....Pages 1288-1295
The Application of Nd-Yag Laser in the Surgical Treatment of Skin Cancer....Pages 1296-1298
Front Matter....Pages 1299-1299
Desmoplastic Malignant Melanoma: Case Report....Pages 1301-1305
Amelanotic Malignant Melanoma: Case Report....Pages 1306-1308
An Unusual Case of Dermatofibrosarcoma Protuberans....Pages 1309-1314
Mistletoe Treatment for Melanoma Brain Metastases: A Single Case....Pages 1315-1322
Back Matter....Pages 1323-1331