Sister Chromatid Exchanges: 25 Years of Experimental Research Part B Genetic Toxicology and Human Studies

Front Matter....Pages i-xvii
Sister Chromatid Exchange Analysis in Cultured Peripheral Blood Leukocytes of the Coldwater Marine Fish, Pacific Staghorn Sculpin ( Leptocottus Armatus ): A Feasible System for Assessing Genotoxic Marine Pollutants....Pages 493-508
Sister Chromatid Exchange Studies in the Chick Embryo and Neonate: Actions of Mutagens in a Developing System....Pages 509-533
SCE Induction by Indirect Mutagens/Carcinogens in Metabolically Active Cultured Mammalian Cell Lines....Pages 535-545
Erythrocyte-Mediated Metabolic Activation Detected by SCE....Pages 547-559
The Effect of Erythrocytes and Hemoglobin on Sister Chromatid Exchange Induction in Cultured Human Lymphocytes Exposed to Aniline HC1....Pages 561-567
Development of Rodent Peripheral Blood Lymphocyte Culture Systems to Detect Cytogenetic Damage In Vivo....Pages 569-584
Accumulation of SCEs in Lymphocytes During Chronic Ingestion of a Mutagen....Pages 585-594
Elimination of Cyclophosphamide-Induced SCE in Lymphocytes of Rats with Time Post-Treatment....Pages 595-598
Detection of SCE in Rodent Cells Using the Activated Charcoal Bromodeoxyuridine System....Pages 599-611
Assessment of Sister Chromatid Exchange in Spermatogonia and Intestinal Epithelium in Chinese Hamsters....Pages 613-628
Sister Chromatid Exchanges in Mammalian Meiotic Chromosomes....Pages 629-645
Removal and Persistence of SCE-Inducing Damage in Human Lymphocytes in Vitro....Pages 647-662
Persistence of SCE-Inducing Lesions after G O Exposure of Human Lymphocytes to Differing Classes of DNA-Damaging Chemicals....Pages 663-676
Proliferative Kinetics and Chemical-Induced Sister Chromatid Exchanges in Human Lymphocyte Cultures....Pages 677-693
Importance of the Mitogen in Sister Chromatid Exchange Studies....Pages 695-714
Serum- and Plasma-Dependent Variations of Benzo(a)Pyrene-Induced Sister Chromatid Exchange in Human Lymphocytes....Pages 715-728
Analysis of Sister Chromatid Exchanges in Bloom Syndrome by Use of Endomitotic and Three-Way Differentiation Procedures....Pages 729-740
Complementation Studies in Murine/Human Hybrids Suggest Multiple Etiology for Increased Rate of Sister Chromatid Exchange in Mammalian Cells....Pages 741-763
Different Properties in Lymphoblastoid Cell Lines from Patients with Bloom Syndrome....Pages 765-774
Study of Basal Cell Nevus Syndrome Fibroblasts after Treatment with DNA-Damaging Agents....Pages 775-785
DNA Interstrand Cross-linking, Repair, and SCE Mechanism in Human Cells in Special Reference to Fanconi Anemia....Pages 787-800
Human Health Situation and Chromosome Alterations: Sister Chromatid Exchange Frequency in Lymphocytes from Passive Smokers and Patients with Hereditary Diseases....Pages 801-811
Sensitivities of Peripheral Lymphocytes from Healthy Humans and Cancer Patients to Induction of Sister Chromatid Exchanges by Genotoxicants....Pages 813-823
Value and Significance of SCE in Human Leukemia and Cancer....Pages 825-838
SCE and Cell Cycle Studies in Leukemia....Pages 839-853
Sister Chromatid Exchange in Phytohemagglutinin-Stimulated Lymphocytes of Nonfamilial Cutaneous Malignant Melanoma Patients....Pages 855-858
SCE Induction by Cytostatics and its Relation to Iatrogenic Leukemogenesis....Pages 859-884
Sister Chromatid Exchange Frequency and Cell Cycle Kinetics in Cancer Patients Treated with Cytostatic Drugs....Pages 885-893
Monitoring Patients on Long-Term Drug Therapy for Genotoxic Effects....Pages 895-905
Practical Applications of the SCE Studies for Guiding and Improving Chemotherapy....Pages 907-914
Genotoxicity of Antiamebic, Anthelmintic, and Antimycotic Drugs in Human Lymphocytes....Pages 915-925
Sister Chromatid Exchange Induction by Cigarette Smoke....Pages 927-937
The SCE Test as a Tool for Cytogenetic Monitoring of Human Exposure to Occupational and Environmental Mutagens....Pages 939-955
Sister Chromatid Exchanges in Workers Exposed to Low Doses of Styrene....Pages 957-963
The Effects of Hypolipidemic Peroxisome Proliferators on the Induction of Sister Chromatid Exchanges....Pages 965-974
Ethylene Oxide and Some Factors Affecting the Mutagen Sensitivity of Sister Chromatid Exchange in Humans....Pages 975-985
The Relevance of Sister Chromatid Exchange Studies to Public Health: Prevention and Intervention. Introduction to a General Discussion on the Interpretation of Sister Chromatid Exchange Data....Pages 987-990
Summary of General Discussion....Pages 991-1000
Back Matter....Pages 1001-1033