Signalling Mechanisms — from Transcription Factors to Oxidative Stress

Front Matter....Pages I-X
The [Ca 2+ ] i Concept: from whole Cell to Microdomains....Pages 1-10
Versatile functions of Ca 2+ -binding proteins in signal transduction and Ca 2+ homeostasis....Pages 11-21
Purification of a neurite growth inhibitor (NI-250) from bovine CNS myelin....Pages 23-28
Protein Kinase C and Lipid Signalling for Cellular Regulation....Pages 29-47
Phospholipase D Regulation in Relationship with Several Protein Kinases Activation in Human Neutrophil....Pages 49-55
Phosphatidic Acid Phosphohydrolase: Its Role in Cell Signalling....Pages 57-64
A Novel Form of Type-IV A cAMP Phosphodiesterase found in rat brain....Pages 65-76
Interaction of the Retinal Cyclic Gmp-Phosphodiesterase Inhibitor with Transducin (G t ) and with Other G-Proteins (G i , G o and G s )....Pages 77-85
Identification of stable opioid receptor Go-protein complexes using GTP-binding protein selective antisera....Pages 87-98
The Use of Stably Transfected Cell Lines in the Analysis of Functional Interactions between Goα1 & Giα2 and the α2C10 Adrenoceptor....Pages 99-113
Modulation of the Ampa/Kainate Receptors by Protein Kinase C....Pages 115-124
Interaction of MARCKS, a major protein kinase C substrate, with the membrane....Pages 125-137
Phosphorylase Kinase: A Protein Kinase For All Seasons....Pages 139-156
Signal, Messenger and Trigger Molecules from Free Radical Reactions and their Control by Antioxidants....Pages 157-164
Strategies of Antioxidant Defense: Relations to Oxidative Stress....Pages 165-186
Antioxidants: Molecular Interactions Between Vitamins E And C, Biothiols and Carotenes....Pages 187-216
Biokinetics of Vitamin E in Lipoproteins and Cells....Pages 217-228
Role of Mitochondria in Radical Generation and Toxicity of τ-Butylhydroperoxide Towards Cultured Human Endothelial Cells....Pages 229-240
Hypoxia and Endothelial Cell Adhesiveness....Pages 241-250
Hypoxia activates endothelial cells to release inflammatory mediators and growth factors....Pages 251-260
Oxidative Stress Induced by γ-interferon and Lipopolysaccharide in Rat Hepatocyte Cultures. Relationship with Nitric Oxide Production....Pages 261-269
Effects of Nitric Oxide on Morris Water Maze Performance in Rats: Correlation with cGMP Levels....Pages 271-277
Signal Transduction from the Cytoplasm to the Cell Nucleus by NF-κB/Rel Transcription Factors....Pages 279-303
Functional Analysis of the Glucocorticoid Receptor....Pages 305-364
Adipocyte Differentiation is Dependent on the Induction of the Acyl-CoA Binding Protein....Pages 365-374
TNF-induced Mechanisms for IL6 Gene Induction....Pages 375-382
Regulation of 14 kDa Group II PLA 2 in Rat Mesangial Cells....Pages 383-393
Multifunctional growth factors in morphogenesis and tumor progression....Pages 395-405
Gene Targeting of the Receptor-Like Protein Tyrosine Phosphatase Lar by Homologous Recombination in Mouse Embryonic Stem Cells....Pages 407-419
Lipid Modifications of Eukaryotic Proteins: Biochemistry and Function....Pages 421-428
Intracellular Synthesis, Transport and Sorting of Glycosphingolipids....Pages 429-441
Note to the Addendum....Pages 443-443
Interleukin lα and Tumor Necrosis Factor-α modulate the nuclear phosphoinositide signaling system....Pages 445-452
Back Matter....Pages 453-462