Signal Transduction and Protein Phosphorylation

Front Matter....Pages i-x
Front Matter....Pages 1-1
Protein Phosphorylation: A Historical Overview....Pages 3-10
Signal Transduction through cAMP and cGMP....Pages 11-15
Signal Cascades in Regulation of Glycogenolysis....Pages 17-30
The Role of Zero-Order Ultrasensitivity Amplification in the Regulation of the Glycogen Phosphorylase A — Phosphorylase B Cycle....Pages 31-35
Protein Sequencing and Covalent Processing....Pages 37-43
Protein Crystallography....Pages 45-54
Signal Transduction by the Adenylate Cyclase System....Pages 55-63
Protein Phosphorylation/Dephosphorylation and Reversible Phosphoprotein Binding in Rhabdomeric Photoreceptors....Pages 65-70
Utilization of a Monoclonal Antibody to Study in Vitro Phosphorylation of a Low Km Phosphodiesterase....Pages 71-79
Sensitivity of a cAMP PDE to Rolipram in Different Organs....Pages 81-85
Immunolocalization of Proteins in Situ by Light and Electron Microscopy....Pages 87-91
Fluorescent Probes....Pages 93-97
Binding of Fluorescent Analogs of Cyclic GMP to cGMP-Dependent Protein Kinase....Pages 99-104
Front Matter....Pages 105-105
Regulation of Actomyosin ATPase....Pages 107-113
Regulation of Muscle Contraction....Pages 115-119
Determination of Phosphates in Cardiac Troponin by Phosphate Analysis and Phosphoserine Modification....Pages 121-125
Myosin Light Chain Kinase....Pages 127-133
Contractile Protein Isoforms....Pages 135-139
Actin Polymerization....Pages 141-147
ADP-Ribosylation of Actin by Botulinum C2 Toxin....Pages 149-153
Front Matter....Pages 105-105
Actin-Binding Proteins....Pages 155-160
Modulation of Cardiac Ca Channels by Phosphorylation....Pages 161-175
Regulation of the Ca-Channel by Phosphorylation-Dephosphorylation....Pages 177-181
Front Matter....Pages 183-183
The Protein Kinase Family....Pages 185-193
Protein Kinase C of Intestinal Epithelium: Its Role in the Control of Ionic Transport....Pages 195-199
Prostaglandin-E 1 - and Sodium Nitroprusside-Regulated Protein Phosphorylation in Platelets....Pages 201-205
Structure, Function and Regulation of Protein Phosphatase....Pages 207-217
High Molecular Weight Phosphorylase Phosphatase from Muscle Glycogen Particles....Pages 219-223
Subcellular Distribution and Characteristics of Hepatic Protein Phosphatases Acting on Glycogen Phosphorylase and on Glycogen Synthase....Pages 225-230
Acute Hormonal Regulation of Lipolysis and Steroidogenesis....Pages 231-237
The Role of Phosphorylation in the Regulation of Acetyl-CoA Carboxylase Activity by Insulin and other Hormones....Pages 239-242
Glycogen Metabolism in Smooth Muscle....Pages 243-257
The Sites of Interaction of Calmodulin with Phosphofructokinase....Pages 259-263
Phosphorylation Sites on Tyrosine Hydroxylase....Pages 265-269
Front Matter....Pages 271-271
Regulation of Amino Acids Biosynthesis in Prokaryotes....Pages 273-287
Desensitization of Glucagon-Stimulated Adenylate Cyclase is Mediated by Stimulation of Inositol Phospholipid Metabolism....Pages 289-292
Phosphoinositide-Hydrolysis in a Stimulated Murine T Cell Clone....Pages 293-297
Phosphorylation of Two Different forms of the Cytoskeletal Protein Caldesmon by Protein Kinase C....Pages 299-303
Guanine Nucleotide Regulatory Protein Couples Angiotensin II Receptors to Phospholipase C in Mesangial Cells....Pages 305-309
Metabolism of Phosphatidylinositol in Reticulocytes — Isoproterenol Affects the Turnover of Polyphosphoinositides....Pages 311-316
Front Matter....Pages 271-271
Role of Cytoplasmic pH for Stimulus-Induced CA 2+ Mobilization in Human Platelets....Pages 317-321
Phosphatidylinositol Phosphorylation in Fast Skeletal Muscle Membranes....Pages 323-327
The Role of Phosphorylation in Growth Control and Malignant Transformation....Pages 329-344
The Effects of Botulinum Neurotoxin and Tetrodotoxin on Protein Phosphorylation in Pure Cholinergic Synaptosomes....Pages 345-350
Protein Phosphorylation in Membranes of Nicotiana Tabacum....Pages 351-356
Interleukin 1 Induces Tyrosine Phosphorylation in Plasma Membranes of the Tumor Cell Lines K 562 and BW 5147....Pages 357-361
The Regulation of cAMP-Dependent Protein Kinases in Normal and Transformed L6 Myoblasts....Pages 363-367
Protein Phosphorylation in Response to Diverse Mitogenic Agents in Dog Thyroid Cells....Pages 369-373
Control of Protein Synthesis Initiation Factor eIF-2α Phosphorylation by Interferon....Pages 375-381
Growth Factor-Mediated Activation of S6 Phosphorylation and Protein Synthesis....Pages 383-389
Inactivation of an S6 Kinase by Protein Phosphatases....Pages 391-396
Back Matter....Pages 397-400