Side Effects of Anti-Inflammatory Drugs IV: The Proceedings of the IVth International Meeting on Side Effects of Anti-inflammatory Drugs, held in Sheffield, UK, 7–9 August 1995

Front Matter....Pages i-xii
Front Matter....Pages 1-1
Current Status of Side-Effects from Anti-Inflammatory Drugs....Pages 3-7
Front Matter....Pages 9-9
The Placebo Response: Clinical Efficacy and Toxicity....Pages 11-23
Side-Effects of Non-Steroidal Anti-Inflammatory Drugs: Studies from the Tayside Medicines Monitoring Unit....Pages 25-30
Treatment Decisions, Side-Effect Liability and Cost-Effectiveness in Osteoarthritis....Pages 31-34
Measuring Beneficial and Adverse Events in Osteoarthritis Clinical Trials....Pages 35-42
Do NSAIDs Adversely Affect Joint Pathology in Osteoarthritis?....Pages 43-53
Safety of Non-Steroidal Anti-Inflammatory Drugs during Pregnancy and Lactation....Pages 55-65
Side-Effects from Biologics in the Therapy of Rheumatic Diseases....Pages 67-76
Oral Tolerance from a General Perspective, and the Possible Role of Side-Effects in the Gut....Pages 77-80
Summary of Debate....Pages 81-84
Front Matter....Pages 85-85
The Concept of Conditional Pharmacology and Toxicology....Pages 87-95
Inflammation, Stress and Environmental Factors as Determinants of Nsaid Efficacy and Toxicity....Pages 97-101
Do You Really Know What Your Drug Looks Like or How it Reacts?....Pages 103-118
Front Matter....Pages 119-119
Intestinal Pathology from NSAIDs....Pages 121-138
A Clinician’s View of Strategies for Preventing Nsaid-Induced Gastrointestinal Ulcers....Pages 139-152
Protection from Nsaid-Induced Gastrointestinal Damage....Pages 153-159
An Overview of the Key Role of Misoprostol in the Prophylaxis of Nsaid-Associated Ulcers and Their Complications....Pages 161-170
Clinical Update of the Relative Safety of Nabumetone in Long-Term Clinical Trials....Pages 171-181
Global Analysis of Gastrointestinal Safety of a New Nsaid, Meloxicam....Pages 183-193
Front Matter....Pages 195-195
Gastrointestinal Adaptation, Regulation of Eicosanoids, and Mucosal Protection from NSAIDs....Pages 197-205
Front Matter....Pages 195-195
New Insight into Nsaid-Induced Gastropathy....Pages 207-210
Cyclooxygenase Selectivity and NSAIDs: Cyclooxygenase-2 Selectivity of Etodolac (Lodine)....Pages 211-221
Differential Inhibition of Cyclooxygenase-1 (COX-1) and -2 (COX-2) by NSAIDs: Consequences on Anti-Inflammatory Activity Versus Gastric and Renal Safety....Pages 223-232
Polymer Delivery of the Mucosal Protective Prostaglandin Misoprostol....Pages 233-234
Nitric Oxide-Releasing NSAIDs, a Novel Class of Safe and Effective Anti-Inflammatory Agents....Pages 235-242
Mitochondrial Function and Modification of Nsaid Carboxyl Moiety....Pages 243-248
Effects of a New Class of No-Releasing NSAIDs on Platelets and Isolated Arteries....Pages 249-256
A 1 and A 2 Adenosine Receptors Mediate Opposite Effects on Nsaid-Induced Gastric Ulcers in the Rat....Pages 257-263
Role of Vagal Nerve in Defence Mechanisms against NSAID-Induced Gastrointestinal Mucosal Damage....Pages 265-286
Analysis of the Inhibiting Activity of Presynaptic α 2 -Adrenoceptors against NSAID-induced Gastric Mucosal Lesions in the Rat....Pages 287-294
Front Matter....Pages 295-295
Mechanisms of Adverse Reactions in the Skin from Anti-Rheumatic Drugs....Pages 297-303
Can In-Vitro Assays Predict Chemically-Induced Skin Damage?....Pages 305-314
Front Matter....Pages 315-315
The Use of Ketorolac Tromethamine Oral Rinse for the Treatment of Periodontitis in Adults....Pages 317-324
Front Matter....Pages 325-325
Variability in Risk of Major Upper Gastro-Intestinal Complications with Individual NSAIDs. Importance of Drug Dose and Half-Life; Results of Meta Analysis....Pages 327-327
Non-Steroidal Associated Ulcer Bleeding — Defining the Risk Factors....Pages 328-328
Variability in Exposure to NSAIDs in Relation to Safety....Pages 328-329
Non-Steroidal Anti-Inflammatory Drugs and Infertility....Pages 329-330
Perioperative Use of NSAID and Postoperative Infectious Complications....Pages 330-330
Medico-Legal Issues of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)....Pages 330-332
The Use of DMARDs and Combination Therapies....Pages 333-333
Front Matter....Pages 325-325
Non-Steroidal Anti-Inflammatory Drugs and Acute Appendicitis: A Case-Control Study....Pages 333-334
Non-Steroidal Anti-Inflammatory Drugs and Colitis: A Record-Linkage Case-Control Study....Pages 334-334
New Exposure to NSAIDs and Hospitalisation for Upper Gastrointestinal Events....Pages 335-335
Topical NSAIDs and Upper Gastrointestinal Bleeding and Perforation....Pages 335-336
Non-Steroidal Anti-Inflammatory Drugs, Aspirin and Colo-Rectal Cancer....Pages 336-337
The Pattern of Prescribing of Community Dispensed Ulcer-Healing Drugs in Tayside....Pages 337-338
Clinical Trials of the Relative Safety of Nabumetone in Long-Term Clinical Trials: Proposed Rationale for Safety Profile....Pages 338-339
Cyclooxygenase-2: A Novel Target for Safer Anti-Inflammatory Drugs....Pages 339-340
Inhiibitory Action of Hydrophilic Polymers on Gastric Lesions Induced by Indomethacin in Rats....Pages 340-341
Copper-Derivatives and Gastroprotection....Pages 341-342
The β 3 -Adrenoceptor Agonist CL316243 Prevents Indomethacin-Induced Jejunal Ulceration in the Rat....Pages 343-344
Front Matter....Pages 345-345
The Dilemma of Modern Medicine....Pages 347-350
Back Matter....Pages 351-356