Serotonin: Actions, Receptors, Pathophysiology

Front Matter....Pages i-xv
Front Matter....Pages 1-1
The Development of 5-HT2 Receptor Antagonists....Pages 3-11
The Development of 5-HT3 Receptor Antagonists....Pages 12-17
Front Matter....Pages 19-19
5-HT Receptors on Afferent Neurones....Pages 21-30
Electrophysiological Investigation of the Actions of 5-Hydroxytryptamine on Sympathetic Ganglionic Neurones....Pages 31-36
Multiple 5-HT Receptors in the Enteric Nervous System....Pages 37-47
Pre-synaptic 5-HT Receptors Mediating Inhibition of Transmitter Release from Peripheral Cholinergic and Noradrenergic Nerves....Pages 48-55
5-HT Receptors Mediating Pre-synaptic Autoinhibition in Central Serotoninergic Nerve Terminals....Pages 56-63
Need the Autoregulation of Raphe Neurones Involve 5-Hydroxytryptamine?....Pages 64-69
Neuronal Actions of 5-Hydroxytryptamine: An Overview....Pages 70-76
Front Matter....Pages 77-83
Behavioural Correlates of the Activation of 5-HT Receptors....Pages 85-85
5-HT3 Receptors in the Central Nervous System....Pages 87-94
Serotoninergic Function and Aggression in Animals....Pages 95-100
Behavioural Actions of 5-Hydroxytryptamine: An Overview....Pages 101-108
Front Matter....Pages 109-112
Cardiac Actions of 5-Hydroxytryptamine....Pages 113-113
Amplifying Action of 5-Hydroxytryptamine in the Rabbit Ear Artery....Pages 115-122
Serotonin-induced Vasoconstriction and Contractile Synergism with Noradrenaline: Role of α-Adrenoceptors....Pages 123-129
Pre-synaptic Sympathetic Inhibition and 5-Hydroxytryptamine-induced Vasodilatation....Pages 130-135
5-HT1A Receptors and Cardiovascular Control....Pages 136-145
Cardiac, Vascular and other Smooth-muscle Actions of 5-Hydroxytryptamine: An Overview....Pages 146-151
Front Matter....Pages 152-156
The Subclassification of Functional 5-HT1-like Receptors....Pages 157-157
New Pharmacological Tools for Studies of Central 5-HT1A Binding Sites....Pages 159-168
Serotonin 5-HT1C Receptors: What Do They Do?....Pages 169-179
Characterization of 5-HT1 Binding Site Subtypes Labelled by [3H]-5-Hydroxytryptamine....Pages 180-187
The Classification of 5-HT Receptors Using Tryptamine Analogues....Pages 188-194
Classification of 5-HT Receptors and Binding Sites: An Overview....Pages 195-203
Front Matter....Pages 204-221
Vascular Actions of Serotonin in Large and Small Arteries are Amplified by Loss of Endothelium, Atheroma and Hypertension....Pages 223-223
Sympathetic Nerves Associated with Brain Vessels Store and Release Serotonin which Interacts with Noradrenaline in Cerebrovascular Contraction....Pages 225-232
5-HT3 Receptors in the Gastrointestinal Tract....Pages 233-240
Different Recognition Sites for Serotonin: The Neuronal Na+-dependent Transporter and the Release-modulating Autoreceptor....Pages 241-248
Serotoninergic Function in Neuropsychiatric Disorders....Pages 249-256
Pharmacology and Function of Melatonin Receptors in the Mammalian Central Nervous System....Pages 257-264
PathoPhysiology of 5-Hydroxytryptamine: An Overview....Pages 265-273
Back Matter....Pages 274-279
....Pages 281-287