Serotonin: From Cell Biology to Pharmacology and Therapeutics

Front Matter....Pages i-xviii
Serotonin Research: Historical Overview....Pages 1-4
Front Matter....Pages 5-5
Molecular Biology of the Serotonin Receptor Family....Pages 7-11
Molecular Structure of the Central 5-HT 1A Receptor....Pages 13-17
Biochemical Characterization of the Cloned Human 5-HT1A Receptor Expressed in Mammalian Cells....Pages 19-24
Amplifying Effects of 5-Hydroxytryptamine on Human Platelets and Signal Transduction....Pages 25-31
Role of Phosphoinositide Hydrolysis and Protein Kinase C Activation in 5HT 2 Receptor Function in Smooth Muscle....Pages 33-37
Adenylate Cyclase-Linked 5-Hydroxytryptamine Receptors in the Brain....Pages 39-51
Characterization and Purification of the Neuronal 5-HT Transporter....Pages 53-60
Structure and functional expression of cloned human liver MAO A and B....Pages 61-65
Front Matter....Pages 67-67
Amplifying Effect of Serotonin in the Control of Vascular Tone....Pages 69-76
Amplification Mechanisms in Platelet Activation....Pages 77-80
The Role of the Endothelium in the Cardiovascular Response to Serotonin....Pages 81-96
Endothelium-Dependent Relaxations to Serotonin: Signal Transduction and Effects of Diets....Pages 97-104
5-Hydroxytryptamine in Cerebrovascular Sympathetic Nerves and its Effect on Brain Vessels....Pages 105-115
The 5-HT System of Blood Platelets: Physiological Variations and Pathophysiology in Essential Hypertension....Pages 117-121
Serotonergic Regulation of Renin and Vasopressin Secretion....Pages 123-129
5 HT, Platelets and Experimental Atherosclerosis....Pages 131-135
Responses to Serotonin in Atherosclerotic and Hypertensive Blood Vessels....Pages 137-140
Does the Serotonin Antagonist Ketanserin have Vascular Protective Effects?....Pages 141-146
Serotonin and Coexisting Peptides in Cat and Lamprey Spinal Cord....Pages 149-154
Front Matter....Pages 67-67
Is There an Endogenous Modulation of Serotonin Uptake?....Pages 155-159
Serotonin Receptors Regulating Transmitter Release....Pages 161-168
Galanin/5-HT Receptor Interactions. A New Integrative Mechanism in the Control of 5-HT Neurotransmission in the Central Nervous System....Pages 169-185
Changing Views on the Role of Serotonergic Mechanisms in the Control of the Sleep-Wakefulness Cycle....Pages 187-191
Serotonin Transmission and Food Intake....Pages 193-202
Serotonin in Medial Hypothalamic Nuclei Controls Circadian Patterns of Macronutrient Intake....Pages 203-211
Serotonin Receptor Sub-Types and the Organisation of Feeding Behaviour: Experimental Models....Pages 213-219
Tryptophan Availability and Serotonin Synthesis....Pages 221-225
Effects of Serotonin on Gastric Secretion in Vivo ....Pages 229-233
Serotonin in Intestinal Function....Pages 235-239
Messenger Function of Serotonin in the Enteric Nervous System....Pages 241-249
5-Hydroxytryptamine and Cholinergic Function in the Gastrointestinal Tract....Pages 251-255
Front Matter....Pages 257-257
Functional/Clinical Significance of 5-Hydroxytryptamine Binding Sites....Pages 259-263
Selective Agonists and Antagonists at 5-Hydroxytryptamine Receptor Subtypes....Pages 265-276
Electrophysiology of Brain Serotonin Receptors: Subtype Specificity for Effector Mechanisms....Pages 277-282
5-Hydroxytryptamine (5-HT) Receptor Subtypes in Invertebrates....Pages 283-288
5-Hydroxytryptamine 1A Receptors: Pharmacological and Functional Characterization....Pages 289-293
Modulation of Serotonin Release in the Central Nervous System via Presynaptic 5-HT Autoreceptors....Pages 295-300
Receptor Binding Correlates of Functional Terminal 5-HT Autoreceptors....Pages 301-307
Pharmacology, Function and Adaptive Regulation of 5HT-1c Receptors....Pages 309-315
Front Matter....Pages 257-257
Classification of Serotonergic Receptors: An Example of a Novel 5-HT 1 -Like Binding Site in the Rabbit Caudate Nucleus....Pages 317-321
Central and Peripheral 5-HT 2 Receptors: Role in Physiological Versus Pathological Conditions....Pages 323-329
5-HT 3 Receptors....Pages 331-338
Brain 5-HT 3 Receptors....Pages 339-345
Heart 5-HT Receptors. A Novel 5-HT Receptor in Human Atrium....Pages 347-354
Characterization of the Contractile 5HT Receptor in the Rat Stomach Fundus....Pages 355-359
Peripheral Neural 5-HT Receptors: Subtypes in the Enteric Nervous System....Pages 361-371
Antagonistic Modulation of A K + Channel Activity by Serotonin and the Peptide FMRFamide in Aplysia Sensory Neurons: Molecular Aspects and Functional Implications....Pages 373-381
Visualization of Serotonin Receptor Binding and Their Messenger RNA’S in the Mammalian Brain: An Update....Pages 383-387
Front Matter....Pages 389-389
Upregulation of Pain Transmission from Deficient Serotonergic Analgesia in Migraine....Pages 391-404
Selective 5-Hydroxytryptamine 1 -Like Receptor Agonists and Migraine....Pages 405-409
Recent Insights into the Antihypertensive Mechanism of Action of Ketanserin....Pages 411-416
Ketanserin Interactions with Nifedipine and Captopril: Two Italian Cross over Trials....Pages 417-427
International Study of Ketanserin in Raynaud’s Phenomenon....Pages 429-433
Serotonin and Portal Hypertension....Pages 435-438
Effects of Serotonin and Ketanserin on the Functional Morphology of Skin: Organotypical Cultures of Adult Human Skin and Embryonic Chick Skin as Experimental Models....Pages 439-446
Use of Antagonists to 5-HT2 Receptors of Serotonin by Topical Application in Healing Skin Ulcers....Pages 447-449
Ketanserin in Wound Healing and Fibrosis: Investigations into its Mechanism of Action....Pages 451-455
Serotonin Uptake Inhibitors....Pages 459-464
Serotonergic Re-Uptake Inhibition and Depression: The Effects of Fluvoxamine on Sleep in Depressed Patients....Pages 465-470
Front Matter....Pages 389-389
Chronobiological Studies of Serotonin Uptake Complex: Relevance to Antidepressant Action....Pages 471-479
Lack of Serotonergic Influence on Desipramine-Induced ß-Adrenergic Receptor Down-Regulation....Pages 481-485
Serotonin in Depression and Anxiety....Pages 487-491
Investigations of 5-HT Neuroendocrine Function in Depression....Pages 493-497
Electrophysiological Investigation of the Effects of Antidepressant Treatments on Serotonin Receptors....Pages 499-504
Role of 5HT2 Receptors in Anxiety and Depression....Pages 505-509
Effectiveness of Ritanserin on Pain and Depression in Chronic Headache Disorders....Pages 511-515
5-HT 1A Receptor Partial Agonists as Anxiolytics....Pages 517-522
5HT 2 Receptor Antagonism and Slow Wave Sleep in Man....Pages 523-530
Serotonin Involvement in the Action of Antipsychotic Drugs....Pages 531-541
Serotonin Control on Anxiety....Pages 543-548
Endocrine Changes and 5-Hydroxytryptamine Receptor Subtypes....Pages 551-557
Neuroendocrine Effects of Serotonin Agonists in Rhesus Monkeys, Healthy Humans and Patients with Depression or Anxiety Disorders: Effects of Antidepressant Treatment....Pages 559-563
Hormonal Responses to Serotonergic Drugs as a Means to Evaluate Brain Serotonergic Function in Humans....Pages 565-580
Role of Serotonin in the Control of Prolactin Secretion: Effect of Antiserotoninergic Drugs in Normal Subjects and in Hyperprolactinaemic States....Pages 581-588
Serotonin Agonist Induced Corticosterone and Prolactin Secretion: Role of 5-HT 2 and 5-HT 1A Receptors....Pages 589-593
Role of Serotonin in Regulation of the Pituitary-Adrenocortical Axis in Rats....Pages 595-599
Front Matter....Pages 601-601
Toxicity of Amphetamine-Related Drugs and Resulting Behavioral Changes....Pages 603-607
Effect of Chronic D-Fenfluramine Administration on Rat Brain Serotonin Levels and Release....Pages 609-613
Behavioral Effects of 5, 7-DHT and MDMA Treatment in Rats....Pages 615-623
Front Matter....Pages 601-601
Immunohistochemical and Autoradiographic Investigations of High-Dose Fenfluramine Treatment on Monoamine Neurons in Rat Brain....Pages 625-629
Long Term Actions of Dexfenfluramine on Food Intake, Body Weight and Brain Serotonin in Rodents....Pages 631-635
Significance of Fenfluramine Neurotoxicity: A Kinetic Approach....Pages 637-643
Effect of D-Fenfluramine on Appetite in Lean and Obese Human Subjects and on Changes Associated with PMS (Pre-Menstrual Syndrome)....Pages 645-649
Criteria for Assessing Drug-Induced Biochemical Alterations and Degeneration of Serotonergic Neurons....Pages 651-660
Back Matter....Pages 661-668