Serotonin and Behavior

Content: 
Front Matter, Page iii
Copyright, Page iv
Biography, Page v
CONTRIBUTORS, Pages xiii-xix
PRECLINICAL PSYCHOPHARMACOLOGY RESEARCH REVIEW COMMITTEE (JANUARY 1972), Page xxi
PREFACE, Pages xxiii-xxiv, Jack Barchas, Earl Usdin
WELCOMING STATEMENT, Page xxv, David A. Hamburg
Session 1 - BIOCHEMISTRY AND PHARMACOLOGY: TRYPTOPHAN HYDROXYLASE AND INHIBITORS OF TRYPTOPHAN HYDROXYLASE, Page 3, M.A. Lipton Moderator
DOES THE TOTAL TURNOVER OF BRAIN 5-HT REFLECT THE FUNCTIONAL ACTIVITY OF 5-HT IN BRAIN?, Pages 5-7, D.G. Grahame-Smith
METABOLISM OF p-CHLOROPHENYLALANINE AND THE MOLECULAR ASPECTS OF ITS ACTION, Pages 9-18, E.M. Gál
ASSAYS AND PROPERTIES OF TRYPTOPHAN 5-HYDROXYLASE, Pages 19-32, J. Renson
COMPARATIVE STUDIES ON THE EFFECT OF PARACHLOROPHENYLALANINE ON HYDROXYLATION OF TRYPTOPHAN IN PINEAL AND BRAIN OF RAT, Pages 33-47, T. Deguchi, J. Barchas
PHYSIOLOGIC AND DRUG-INDUCED REGULATION OF SEROTONIN SYNTHESIS, Pages 49-54, W. Lovenberg, G.H. Besselaar, R.E. Bensinger, R.L. Jackson
TRYPTOPHAN HYDROXYLASE INHIBITORS OTHER THAN PCPA, Pages 55-59, E.G. McGeer
SOME DRUG EFFECTS ON THE FUNCTIONS OF THE TWO MEASURABLE FORMS OF TRYPTOPHAN-5-HYDROXYLASE: INFLUENCE ON HYDROXYLATION AND UPTAKE OF SUBSTRATE, Pages 61-71, S. Knapp, A.J. Mandell
DISCUSSION - BIOCHEMISTRY AND PHARMACOLOGY: TRYPTOPHAN HYDROXYLASE AND INHIBITORS OF TRYPTOPHAN HYDROXYLASE, Pages 73-82
Session 2 - PHYSIOLOGY AND PHARMACOLOGY: LOCALIZATION, UPTAKE, AND METABOLISM OF SEROTONIN, Page 85, S. Spector Moderator
LOCALIZATION AND TRANSPORT OF SEROTONIN, Pages 87-96, A. Dahlström, J. Häggendal, C. Atack
SEROTONIN UPTAKE SYSTEMS IN BRAIN TISSUE, Pages 97-108, S.H. Snyder, E.G. Shaskan, M.J. Kuhar
THE ROLE OF SEROTONIN N-ACETYLTRANSFERASE IN THE ADRENERGIC REGULATION OF INDOLE METABOLISM IN THE PINEAL GLAND, Pages 109-119, D.C. Klein
CONTROL OF BRAIN 5-HT CONTENT BY DIETARY CARBOHYDRATES, Pages 121-128, J.D. Fernstrom, R.J. Wurtman
THE NORMAL OCCURRENCE OF TRYPTAMINE IN BRAIN AND ITS CONVERSION TO N-METHYL AND N-DIMETHYLTRYPTAMINE IN VITRO AND IN VIVO, Pages 129-135, J.M. Saavedra, J. Axelrod
THE ROLE OF BRAIN SEROTONIN IN THE PHARMACOLOGIC EFFECTS OF THE METHYL XANTHINES, Pages 137-147, B. Berkowitz, S. Spector
SUPPRESSION OF BRAIN SEROTONIN SYNTHESIS AND METABOLISM BY BENZODIAZEPINE MINOR TRANQUILIZERS, Pages 149-155, J.A. Dominic
DISCUSSION - PHYSIOLOGY AND PHARMACOLOGY: LOCALIZATION, UPTAKE, AND METABOLISM OF SEROTONIN, Pages 157-162
Session 3 - PHYSIOLOGY AND PHARMACOLOGY: DEPLETION OF SEROTONIN, Pages 165-166, A. Weissman Moderator
SEROTONIN AND CONVULSIONS, Pages 167-172, W.O. Boggan
BRAIN SEROTONIN AND THE PITUITARY-ADRENAL SYSTEM, Pages 173-177, J. Vernikos-Danellis, P.A. Berger
RELATIONSHIP BETWEEN TELENCEPHALIC CONTENT OF SEROTONIN AND PAIN SENSITIVITY, Pages 179-189, J.A. Harvey, L.M. Yunger
RECENT STUDIES ON THE MECHANISM OF ACTION OF CHLORINATED AMPHETAMINES, Pages 191-199, E. Sanders-Bush
AN APPROACH TO THE ASSAY OF SEROTONIN USING GAS-LIQUID CHROMATOGRAPHY AND MASS FRAGMENTOGRAPHY - THE PINEAL GLAND AS A MODEL SYSTEM, Pages 201-207, J. DoAmaral
EFFECTS OF 5,6-DIHYDROXYTRYPTAMINE ON BRAIN MONOAMINE NEURONS IN THE RAT, Pages 209-224, H.G. Baumgarten, H.G. Schlossberger
DISCUSSION - PHYSIOLOGY AND PHARMACOLOGY: DEPLETION OF SEROTONIN, Pages 225-229
Session 4 - NEUROPHYSIOLOGY: EFFECTS OF ALTERING SEROTONIN ON CENTRAL NERVOUS SYSTEM NEURONS, Page 233, J.A. Harvey Moderator
BEHAVIORAL PHARMACOLOGY OF p-CHLOROPHENYLALANINE (PCPA), Pages 235-248, A. Weissman
THE PHYSIOLOGY AND PHARMACOLOGY OF SEROTONIN MEDIATED SYNAPSES, Pages 249-261, F.E. Bloom, B.J. Hoffer, C. Nelson, Y-s. Sheu, G.R. Siggins
DIRECT AND INDIRECT ACTIONS OF LSD, SEROTONIN AND RELATED COMPOUNDS ON SEROTONIN-CONTAINING NEURONS, Pages 263-266, G.K. Aghajanian, H.J. Haigler
5-HT-CONTAINING NEURONS: UNIT ACTIVITY IN BEHAVING CATS, Pages 267-279, D.J. McGinty, R.M. Harper, M.K. Fairbanks
AMYGDALA UNIT ACTIVITY AS A REFLECTION OF FUNCTIONAL CHANGES IN BRAIN SEROTONERGIC NEURONS, Pages 281-289, B.L. Jacobs
SEROTONERGIC RECEPTORS IN THE CENTRAL NERVOUS SYSTEM, Pages 291-292, S.G.A. Alivisatos
THE ROLE OF HYPOTHALAMIC SEROTONIN IN THERMOREGULATION, Pages 293-302, R.D. Myers
DISCUSSION - NEUROPHYSIOLOGY: EFFECTS OF ALTERING SEROTONIN ON CENTRAL NERVOUS SYSTEM NEURONS, Pages 303-308
SESSION 5 - ANIMAL BEHAVIORAL STUDIES: BEHAVIORAL EFFECTS OF ALTERING SEROTONIN IN ANIMALS, Pages 311-314, J.D. Barchas Moderator
EFFECTS OF BEHAVIORAL MANIPULATIONS UPON BRAIN SEROTONIN AND DOPAMINE, Pages 315-324, E.L. Bliss
EFFECTS OF PCPA ON FIGHTING BEHAVIOR AND HABITUATION OF STARTLE RESPONSE IN RATS, Pages 325-333, R.L. Conner, J.M. Stolk, S. Levine
BIOCHEMICAL AND BEHAVIORAL CHANGES IN RATS WITH EXPERIMENTAL PHENYLKETONURIA, Pages 335-349, A.E. Andersen, A.Z. Abramowitz, G. Guroff
EFFECTS OF SEROTONIN DEPLETION ON BEHAVIOR IN MONKEYS, Pages 351-356, J.W. Maas, D.E. Redmond Jr., R. Gauen
EFFECTS OF PARACHLOROPHENYLALANINE ON THE BEHAVIOR OF MONKEYS, Pages 357-364, R.C. Boelkins
CHANGES IN BRAIN SEROTONIN LEVEL AND MALE SEXUAL BEHAVIOR, Pages 365-370, A. Zitrin
DISCUSSION - ANIMAL BEHAVIORAL STUDIES: BEHAVIORAL EFFECTS OF ALTERING SEROTONIN IN ANIMALS, Pages 371-377
Session 6 - ANIMAL BEHAVIORAL STUDIES — SLEEP: THE RELATION OF SEROTONIN TO SLEEP, Pages 381-383, D.X. Freedman Moderator
SEROTONIN AND SLEEP IN THE CAT, Pages 385-400, M. Jouvet
THE EFFECT OF PARACHLOROPHENYLALANINE ON SLEEP IN THE RAT: SOME IMPLICATIONS FOR THE SEROTONIN-SLEEP HYPOTHESIS, Pages 401-418, A. Rechtschaffen, R.A. Lovell, D.X. Freedman, W.E. Whitehead, M. Aldrich
THE EFFECT OF THE CHRONIC ADMINISTRATION OF PARACHLOROPHENYLALANINE (PCPA) ON SLEEP PARAMETERS IN THE CAT, Pages 419-424, W. Dement, S. Henriksen, J. Ferguson
CAT BRAIN SEROTONIN CONTENT DURING SLEEP AND WAKEFULNESS, Pages 425-426, A.K. Sinha
MONOAMINERGIC SYSTEMS IN THE BRAIN AND THEIR ROLE IN THE SLEEP STATES, Pages 427-442, P.J. Morgane, W.C. Stern
5-HTP AND THE SYNDROME OF INTENTION OR ACTION MYOCLONUS AS A SEQUEL TO HYPOXIC ENCEPHALOPATHY, Pages 443-444, C. Guilleminault
DISCUSSION - ANIMAL BEHAVIORAL STUDIES – SLEEP: THE RELATION OF SEROTONIN TO SLEEP, Pages 445-452
Session 7 - HUMAN BEHAVIOR: TESTS FOR SEROTONIN UTILIZATION IN HUMANS AND EFFECTS OF PRECURSOR LOADING IN VARIOUS DISORDERS, Pages 455-456, J.W. Maas Moderator
MONAMINE METABOLISM IN DEPRESSION: CLINICAL APPLICATION OF THE PROBENECID TEST, Pages 457-468, H.M. van Praag, J. Korf
THE USE OF PROBENECID IN HIGH DOSES FOR THE ESTIMATION OF CENTRAL SEROTONIN TURNOVER IN AFFECTIVE ILLNESS AND ADDICTS ON METHADONE, Pages 469-480, F.K. Goodwin, R.M. Post
PRECURSOR LOADING STRATEGIES, Pages 481-482, B.J. Carroll
CEREBROSPINAL FLUID LEVELS OF 5-HYDROXYINDOLEACETIC ACID IN PSYCHIATRIC DISORDERS: A CRITICAL ASSESSMENT, Pages 483-486, S. Wilk
5-HYDROXYTRYPTOPHAN AND CHRONIC SCHIZOPHRENIA - A PRELIMINARY STUDY, Pages 487-497, R.J. Wyatt, T. Vaughan, J. Kaplan, M. Galanter, R. Green
ORAL 5-HYDROXYTRYPTOPHAN EFFECTS ON SLEEP, Pages 499-509, V.P. Zarcone, E. Hoddes, H. Smythe
DISCUSSION - HUMAN BEHAVIOR: TESTS FOR SEROTONIN UTILIZATION IN HUMANS AND EFFECTS OF PRECURSOR LOADING IN VARIOUS DISORDERS, Pages 511-518
SESSION 8 - HUMAN BEHAVIOR: TESTS FOR SEROTONIN UTILIZATION IN HUMANS AND EFFECTS OF PRECURSOR LOADING IN VARIOUS DISORDERS, Page 521, D.A. Hamburg Moderator
ROLE OF SEROTONIN IN AFFECTIVE DISORDERS, Pages 523-527, A. Coppen
BEHAVIORAL AND METABOLIC EFFECTS OF L-TRYPTOPHAN IN UNIPOLAR DEPRESSED PATIENTS, Pages 529-537, D.L. Murphy, M. Baker, J. Kotin, W.E. Bunney Jr.
BALANCE, PERMISSION, AND DISCRIMINATION AMONG AMINES: A THEORETICAL CONSIDERATION OF THE ACTIONS OF L-TRYPTOPHAN IN DISORDERS OF MOVEMENTS AND AFFECT, Pages 539-548, A.J. Prange Jr., J.L. Sisk, I.C. Wilson, C.E. Morris, C.D. Hall, J.S. Carman
CLINICAL STUDIES OF L-5-HYDROXYTRYPTOPHAN IN DEPRESSION, Pages 549-559, H.K.H. Brodie, R. Sack, L. Siever
DISCUSSION - HUMAN BEHAVIOR: TESTS FOR SEROTONIN UTILIZATION IN HUMANS AND EFFECTS OF PRECURSOR LOADING IN VARIOUS DISORDERS, Pages 561-564
SUMMARY OF SEROTONIN AND BEHAVIOR CONFERENCE, Pages 565-568, M.A. Lipton
REFERENCES, Pages 569-627
ABBREVIATIONS, Pages 629-631
SUBJECT INDEX, Pages 633-642