Selenium: Its Molecular Biology and Role in Human Health

Front Matter....Pages i-xxv
History of Selenium Research....Pages 1-19
Front Matter....Pages 21-21
Selenocysteine Biosynthesis and the Replacement of Selenocysteine with Cysteine in the Pathway....Pages 23-31
Molecular Mechanism of Eukaryotic Selenocysteine Incorporation....Pages 33-46
SECIS-Binding Proteins Regulate the Expression of the Selenoproteome....Pages 47-59
A Ribosomal Perspective on the Mechanism of Selenocysteine Incorporation....Pages 61-72
Chemical Basis for the Use of Selenocysteine....Pages 73-83
Evolutionary Basis for the Use of Selenocysteine....Pages 85-93
Selenocysteine Lyase: Mechanism, Structure, and Biological Role....Pages 95-105
Front Matter....Pages 107-107
Selenoproteins and Selenoproteomes....Pages 109-123
Structural Characterization of Mammalian Selenoproteins....Pages 125-136
Selenoproteins: Hierarchy, Requirements, and Biomarkers....Pages 137-152
Selenoproteins and the Thioredoxin System....Pages 153-165
Selenoproteins of the Glutathione Peroxidase Family....Pages 167-180
Glutathione Peroxidase-4....Pages 181-195
Selenoprotein M....Pages 197-203
Selenium Transport in Mammals: Selenoprotein P and Its Receptors....Pages 205-219
Selenoproteins in the Endoplasmic Reticulum....Pages 221-234
Selenoproteins in Nervous System Development, Function, and Degeneration....Pages 235-248
Selenoproteins in Cardiovascular Redox Pathology....Pages 249-259
Glutathione Peroxidase 1 and Diabetes....Pages 261-270
Front Matter....Pages 107-107
Glutathione Peroxidase 2 and Its Role in Cancer....Pages 271-282
Selenoprotein N: Its Role in Disease....Pages 283-294
Front Matter....Pages 295-295
Prostate Cancer Prevention and the Selenium and Vitamin E Cancer Prevention Trial (SELECT): A Selenium Perspective....Pages 297-311
Selenium as a Cancer Preventive Agent....Pages 313-323
Selenoproteins Harboring a Split Personality in Both Preventing and Promoting Cancer....Pages 325-333
An Emerging Picture of the Biological Roles of Selenoprotein K....Pages 335-344
Polymorphisms in Selenoprotein Genes and Cancer....Pages 345-354
Schizophrenia, Oxidative Stress and Selenium....Pages 355-367
Control of Thyroid Hormone Activation and Inactivation by the Iodothyronine Deiodinase Family of Selenoenzymes....Pages 369-381
Role of Selenium in HIV/AIDS....Pages 383-397
Seafood Selenium in Relation to Assessments of Methylmercury Exposure Risks....Pages 399-408
Selenium and Male Reproduction....Pages 409-417
Variations in Selenium Metabolism in Males and Females....Pages 419-432
Selenium in Alzheimer’s Disease....Pages 433-442
Selenium and Inflammation....Pages 443-456
Selenium Metabolism in Prokaryotes....Pages 457-470
Selenoproteins in Parasites....Pages 471-479
Selenium and Methionine Sulfoxide Reduction....Pages 481-492
Inactivation of Glutathione Peroxidase 1 and Peroxiredoxin 2 by Peroxides in Red Blood Cells....Pages 493-503
Functional Aspects of the Genomics of Selenoproteins and Selenocysteine Incorporation Machinery....Pages 505-515
Front Matter....Pages 295-295
Selenium: Dietary Sources and Human Requirements....Pages 517-529
Selenium and Adverse Health Conditions of Human Pregnancy....Pages 531-544
Front Matter....Pages 545-545
Mouse Models for Glutathione Peroxidase 4 (GPx4)....Pages 547-559
Mouse Models that Target Removal or Overexpression of the Selenocysteine tRNA [Ser]Sec Gene to Elucidate the Role of Selenoproteins in Health and Development....Pages 561-572
Selenoproteins in Skeletal Development and Disease: Lessons from Trsp Deletion in Murine Bone and Cartilage Progenitor Cells....Pages 573-587
Back Matter....Pages 589-598