Selenium in Biology and Medicine

Front Matter....Pages I-XVII
Front Matter....Pages 1-1
The Regulation of Glutathione Peroxidase Gene Expression; Implication for Species Difference and the Effect of Dietary Selenium Manipulation....Pages 3-7
Regulation of Expression of Glutathione Peroxidase by Selenium....Pages 8-13
Studies on New Selenoproteins and Specific Selenium Target Tissues....Pages 14-20
Selenium-Containing Proteins in Plasma of Higher Primates....Pages 21-24
Involvement of a Selenoprotein in Glycine, Sarcosine, and Betaine Reduction by Eubacterium acidaminophilum ....Pages 25-28
Dependence of Mouse Liver Phospholipid Hydroperoxide Glutathione Peroxidase on Dietary Selenium....Pages 29-32
Interaction of Heparin with a Selenoprotein in Human Plasma....Pages 33-37
Selenium-Independent Glutathione Peroxidase in Malaria Parasites....Pages 38-42
Synthesis of a Selenium Analogue of Neurospora crassa Metallothionein and Its Properties....Pages 43-46
Reactions of the Thioredoxin System with Selenium....Pages 47-51
Selenite-Induced Variation of Glutathione Peroxidase Activity in Mammalian Cells and Its Consequences for Cellular Radiation Resistance....Pages 52-59
Effects of Selenium Supplementation on Platelet Function as Assessed by Platelet Aggregation and Glutathione Peroxidase Activity....Pages 60-62
Role of Glutathione Peroxidase and α -Tocopherol in Protecting Rat Erythrocytes Against tert -Butyl Hydroperoxide-Induced Hemolysis in Vitro....Pages 63-69
Active Oxygen Generation by the Reaction of Selenite with Reduced Glutathione in Vitro....Pages 70-73
Studies on Selenite-Induced DNA Fragmentation and the Role of Poly(ADP Ribose)Polymerase in Selenite Toxicity....Pages 74-78
Involvement of Cellular Sulfhydryl Compounds in the Inhibition of DNA and RNA Synthesis by Selenite....Pages 79-82
Front Matter....Pages 83-83
Selenium-Dependent Metabolic Modulations in Mouse Liver....Pages 85-89
Selenium Deficiency and Thyroid Hormone Metabolism....Pages 90-95
Glutathione Metabolism as Affected by Selenium Deficiency....Pages 96-100
Selenium-Deficiency and the Metabolism of Ketone Bodies....Pages 101-108
Front Matter....Pages 83-83
Transport of Selenomethionine and Methionine Across the Intestinal Brush Border Membrane....Pages 109-113
Plasma Malondialdehyde and Exhaled Hydrocarbons: Are They Reliable Indicators of Lipid Peroxidation and Glutathione Peroxidase Activity?....Pages 114-116
Biochemical Studies on Selenium and Keshan Disease — The Oxidant Stress and Defence Capacity in Blood of Selenium-Deficient Children....Pages 117-121
Effect of Growth Phase on Deposition of Selenium (Se) in Tissues of Rats Fed Elevated Dietary Levels of Se as Either L-Selenomethionine or Sodium Selenate....Pages 122-125
Selenium Intake Induces Growth Retardation Through Reversible Growth Hormone and Irreversible Somatomedin C Suppression....Pages 126-129
Selenium in the Central Nervous System of the Rat After Exposure to 75-Se-L-Selenomethionine....Pages 130-132
Effect of Selenium on Adriamycin-Induced Cardiotoxicity in Mice....Pages 133-136
Effects of Selenium Deficiency on Mouse Articular Cartilage....Pages 137-141
Myocardial and Pancreatic Damage in Selenium Vitamin E Deficient Mice....Pages 142-150
Front Matter....Pages 151-151
Metabolism and Disposition of Ebselen....Pages 153-162
The Use of Highly Enriched 77 Se in Metabolic Studies of Ebselen in Man — An NMR Investigation....Pages 163-168
Effect of Ebselen (PZ-51) in Liver Failure Induced by Propionibacterium acnes ( P. acnes )....Pages 169-172
Ebselen (PZ-51) Inhibits the Formation of Ischemic Brain Edema....Pages 173-176
Effects of Ebselen (PZ-51) on Experimental Cerebral Vasospasm....Pages 177-184
Ebselen, a Seleno-Organic Compound, Inhibits Leukocyte Aggregation and Reduces the Plasma Leukotriene B 4 Level in Humans and Rats....Pages 185-188
Binding of Ebselen to Plasma Protein....Pages 189-193
Protection of Experimental Cobalt Cardiomyopathy in the Rat by Selenium Pretreatment....Pages 194-198
Correlation of Levels of Platinum and Selenium in Rats Treated with Cisplatin and Sodium Selenite....Pages 199-202
Front Matter....Pages 203-203
Progress in Establishing Human Nutritional Requirements and Dietary Recommendations for Selenium....Pages 205-209
Supplementation of a Population with Selenium — Reasons for Action and Initial Experience....Pages 210-213
Front Matter....Pages 203-203
Selenium Status and Cardiovascular Disease: Dutch Epidemiologic Data....Pages 214-218
Bioavailability of Selenium in a Selected Dutch Population....Pages 219-222
Studies of Human Maximal and Minimal Safe Intake and Requirement of Selenium....Pages 223-228
Are Germans Selenium-Deficient?....Pages 229-233
Blood Selenium Levels of Norwegians Compared to Their Se Intakes....Pages 234-237
The Intake of Selenium and Other Nutrients in a Group of Norwegian Rheumatics....Pages 238-241
Se Supplementation of Fertilizers Has Increased the Se Intake and Serum-Se Concentration of Finnish People....Pages 242-245
Selenium Status of Children and Adults in Northern Germany....Pages 246-249
Urinary Excretion of Selenium (Se) and Trimethyl-selenonium (TMSe) by NZ Women During Long Term Supplementation with Selenate or Selenomethionine (Semet)....Pages 250-253
Selenium (Se) and Glutathione Peroxidase (GSH-Px) in Blood Components of NZ Women During Long Term Supplementation with Selenate or Selenomethionine (Semet)....Pages 254-257
Comparison of Human Response to Low Doses of Inorganic and Organic Selenium....Pages 258-262
The Relativity Between Some Epidemiological Characteristics of Kaschin-Beck Disease and Selenium Deficiency....Pages 263-269
The Selenium and Phospholipid (Phosphatidylcholine) Deficiency and Low Temperature of Environment May be the Pathogenetic Basis of Kaschin-Beck Disease....Pages 270-276
Low Selenium State and Increased Erucic Acid in Children from Keshan Endemic Areas — A Pilot Study....Pages 277-280
Selenium in Children with Acute Leukaemia During Selenium Chemotherapy....Pages 281-285
Selenium Status and Age Effects....Pages 286-293
Front Matter....Pages 295-295
The Influence of Dietary Selenium on Colon, Pancreas, and Skin Tumorigenesis....Pages 297-304
Is Selenium Metabolism Necessary for Its Anticarcinogenic Activity?....Pages 305-312
Low Serum Selenium Level and Elevated Risk of Lung Cancer....Pages 313-316
Study on the Relation of Se, Mn, Fe and Mo to Liver Cancer Mortality....Pages 317-322
Front Matter....Pages 295-295
Determination of Selenium Contents in Sera, Hair and Glutathione Peroxidase Activities in Whole Blood of Nasopharyngeal Carcinoma (NPC) Patients....Pages 323-325
Back Matter....Pages 327-330