Selective Toxicity: The physico-chemical basis of therapy

Front Matter....Pages i-xiii
Front Matter....Pages 1-1
Selectivity in the service of man....Pages 3-18
Steps in the correlation of structure with biological action....Pages 19-50
Differences in distribution: the first principle of selectivity....Pages 51-102
Comparative biochemistry: the second principle of selectivity....Pages 103-151
Comparative cytology the third principle of selectivity....Pages 152-179
Chemotherapy: history and principles....Pages 180-234
Pharmacodynamics....Pages 235-273
Front Matter....Pages 275-275
The nature of chemical bonds. Adsorption....Pages 277-288
Metabolites, enzymes, and metabolite analogues....Pages 289-329
Ionization....Pages 330-384
Metal-binding substances....Pages 385-442
The covalent bond in selective toxicity....Pages 443-475
Steric factors....Pages 476-524
Surface chemistry. The modification of membranes by surface-active agents....Pages 525-542
Biological activity unrelated to structure. Ferguson’s principle....Pages 543-556
The perfection of a discovery....Pages 557-562
Back Matter....Pages 563-662