Selective Activation of Drugs by Redox Processes

Front Matter....Pages i-xi
Characteristics of Hypoxic Cells that Enhance their Susceptibility to Chemical Injury....Pages 1-9
Prediction and Measurement of Redox Properties of Drugs and Biomolecules....Pages 11-24
Metal-Catalyzed Redox Processes in Biological Systems and Drug Activation....Pages 25-37
Redox Systems Generated by Electrochemical Oxidations and Reductions....Pages 39-51
The Role of DNA Damage in the Bioreductive Action of 2-Nitroimidazoles....Pages 53-61
Redox Properties of Radiation Induced Free Radicals....Pages 63-78
Reduction of Bleomycin-Fe by Reductases and Active Oxygen Formation....Pages 79-87
Redox Activation of Drugs by the Red Blood Cell Membrane....Pages 89-95
Induction of Stress Proteins and Drug Resistance by Hypoxia and Applications of Magnetic Resonance Spectroscopy and Cryospectrophotometry for Detecting Hypoxia in Tumors....Pages 97-111
Mechanisms of Activation of Mitomycin C and AZQ in Aerobic and Hypoxic Mammalian Cells....Pages 113-123
Molecular Interactions and Biological Effects of the Products of Reduction of Nitroimidazoles....Pages 125-136
Redox Activation of Benzotriazine N-Oxides: Mechanisms and Potential as Anticancer Drugs....Pages 137-148
Nitroacridines and Nitroquinolines as DNA-Affinic Hypoxia-Selective Cytotoxins....Pages 149-158
Metabolic Effects of Hypoxic Cell Sensitizers....Pages 159-164
Does Ro 03–8799 Concentration in Human Tumour Xenografts Predict Radiosensitization? Comparison with SR-2508....Pages 165-172
Enzyme-Directed Bioreductive Drug Development....Pages 173-191
Improved Treatment of Tumours in vivo by Combining the Bioreductive Drug RSU-1069, Hydralazine and Hyperthermia....Pages 193-202
The Assessment of Bioreductive Drug Toxicity in vitro and in Experimental Tumours in vivo ....Pages 203-212
Activity of Bioreductive Agents in Human and Rodent Tumor Cells....Pages 213-222
The Control of Tumour Oxygenation in Mice: The Importance of Tumour Site....Pages 223-228
Critical Events in the Toxicity of Redox Active Drugs....Pages 229-235
The Reduction Activation of Nitroimidazoles; Modification by Oxygen and other Redox-Active Molecules in Cellular Systems....Pages 237-247
Fluorescent Probes for Hypoxia: Chemical Aspects....Pages 249-262
Toxicity of Metal Complexes with Radiosensitizing Properties....Pages 263-273
Effects on DNA of Bioreducible Nitroimidazole and Benzotriazine Drugs....Pages 275-283
Response of Repair and Reduction Deficient Mutants to Agents Requiring Bioreduction....Pages 285-294
Bioreductive Drugs and Radiation: Pharmacokinetics and Clinical Trials of Etanidazole Radiosensitizer....Pages 295-302
The Oncogenic Potential of Bioreductive Drugs....Pages 303-312
Adduct Formation by 2-Nitroimidazole Drugs in Mammalian Cells: Optimization of Markers for Tissue Oxygenation....Pages 313-323
Tumour Blood Flow and Its Modulation: Implications for Bioreductive Drug Activity in vivo ....Pages 325-336
Cellular Gsh Metabolism During Hypoxia....Pages 337-353
Back Matter....Pages 355-361