Scleroderma: From Pathogenesis to Comprehensive Management

Front Matter....Pages i-xx
Front Matter....Pages 1-1
Historical Perspective....Pages 3-6
Therapeutic Evolution: A Professor’s View....Pages 7-12
Front Matter....Pages 13-13
Overview: Epidemiology, Genetics and Classification....Pages 15-15
Epidemiology and Environmental Risk Factors....Pages 17-28
Genetic Factors....Pages 29-44
Disease Subsets in Clinical Practice....Pages 45-52
Evolving Concepts of Diagnosis and Classification....Pages 53-69
Disease Classification Using Molecular Signatures....Pages 71-81
Front Matter....Pages 83-83
Juvenile Localized Scleroderma....Pages 85-92
Juvenile Systemic Sclerosis....Pages 93-100
Front Matter....Pages 101-101
Scleroderma Mimics....Pages 103-111
Localized Forms of Scleroderma....Pages 113-135
Nephrogenic Systemic Fibrosis....Pages 137-159
Front Matter....Pages 161-161
Overview: Pathogenesis Integrated....Pages 163-164
Immunological Mechanisms....Pages 165-189
Innate Immunity....Pages 191-197
Autoantibodies in Pathogenesis....Pages 199-208
The Clinical Aspects of Autoantibodies....Pages 209-225
Mechanisms of Vascular Disease....Pages 227-246
Vascular Biomarkers....Pages 247-253
Front Matter....Pages 161-161
Mechanism of Fibrosis....Pages 255-265
Fibrosis: Insights from the Stiff Skin Syndrome....Pages 267-282
Biomarkers of Fibrosis....Pages 283-290
Overview of Animal Models....Pages 291-307
Front Matter....Pages 309-309
Overview: Cardiovascular Manifestations and Management....Pages 311-312
Raynaud’s Phenomenon....Pages 313-329
Nailfold Capillaroscopy....Pages 331-346
Systemic Vascular Disease....Pages 347-359
Scleroderma Renal Crisis....Pages 361-371
Cardiac Involvement....Pages 373-393
Erectile Dysfunction....Pages 395-398
Front Matter....Pages 399-399
Overview: Pulmonary Manifestations and Management....Pages 401-402
Clinical Assessment of Lung Disease....Pages 403-413
Computerized Tomography of Interstitial Lung Disease....Pages 415-419
Treatment of Interstitial Lung Disease....Pages 421-427
Clinical Assessment of Pulmonary Hypertension....Pages 429-435
Treatment of Pulmonary Hypertension....Pages 437-445
Complex Challenges of Pulmonary Hypertension....Pages 447-460
Front Matter....Pages 461-461
Overview: Gastrointestinal Manifestations and Management....Pages 463-469
Upper Gastrointestinal Tract....Pages 471-484
Front Matter....Pages 461-461
Small and Large Intestinal Involvement....Pages 485-499
Front Matter....Pages 501-501
Evaluation and Management of Skin Disease....Pages 503-523
Skeletal Muscle Involvement....Pages 525-530
Tendons, Joints, and Bone....Pages 531-545
Pregnancy....Pages 547-557
Overlooked Manifestations....Pages 559-568
Front Matter....Pages 569-569
Principles of Management....Pages 571-576
Immunomodulatory Therapies....Pages 577-589
Cell-Based Therapies....Pages 591-602
Investigative Approaches to Drug Therapy....Pages 603-613
Complementary and Alternate Medicine Approaches....Pages 615-628
Physical and Occupational Therapy....Pages 629-639
Evaluation and Management of Psychosocial Issues....Pages 641-648
Front Matter....Pages 649-649
Issues in Clinical Trial Design....Pages 651-660
Measuring Disease Activity and Outcomes in Clinical trials....Pages 661-671
Patient-Reported Outcomes....Pages 673-678
Back Matter....Pages 679-689