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Schizophrenia is one of the most complex and disabling diseases
to affect mankind. Relatively little is known about its
nature and its origins, and available treatments are inadequate
for most patients. As a result, there are inevitable
controversies about what causes it, how to diagnose it, and how
best to treat it. However, in the past decade, there has
been an explosion of new research, with dramatic discoveries
involving genetic etiology and epidemiological risk
factors. There has also been a catalog of new drugs
coming to market, and controversy about the relative advantages
and disadvantages of newer compared with older therapies.
In addition, developing technologies in genomics,
molecular biology and neuroimaging provide streams of new
information.
This book represents a definitive, essential, and up-to-date
reference text on schizophrenia. It extensively and
critically digests and clarifies recent advances and places
them within a clinical context. The Editors (one
American and one British), highly respected clinical
psychiatrists and researchers and acknowledged experts on
schizophrenia, have again assembled an outstanding group of
contributors from the USA, UK, Europe and Australia, It will
be of value to practising psychiatrists and to trainees, as
well as to clinical and neuroscience researchers interested
in keeping up with this field or coming into it.
The book consists of four sections: descriptive
aspects, biological aspects, physical treatments, and
psychological and social aspects. It reviews the
theoretical controversies over symptomatology, classification
and aetiology (particularly pertinent as DSM-V is being
developed), the relationship of schizophrenia to the other
psychoses, the significance of positive and negative symptoms
and pre-morbid personality. It describes a variety of
approaches to integrating the vast research data about
schizophrenia, including neurodevelopmental, genetic,
pharmacological, brain imaging and psychological findings.
The biological treatment section reviews the comparative
efficacy of various drugs, the management of drug-resistant
patients and both neurological and metabolic complications.
The final section looks at psychological therapies, social
outcomes, and the economics of schizophrenia.
Highly Commended in the Psychiatry section of the
2012 BMA Book Awards.
Content:
Chapter 1 Concept of Schizophrenia: Past, Present, and Future
(pages 1–8): Nancy C. Andreasen
Chapter 2 The Schizophrenia Construct: Symptomatic Presentation
(pages 09–23): Celso Arango and William T. Carpenter
Chapter 3 Child and Adolescent Schizophrenia (pages 24–46):
Chris Hollis and Judith Rapoport
Chapter 4 Late?Onset Schizophrenia (pages 47–61): Robert Howard
and Dilip Jeste
Chapter 5 The Schizophrenia Spectrum Personality Disorders
(pages 62–90): Eran Chemerinski and Larry J. Siever
Chapter 6 The Prodrome of Schizophrenia (pages 91–103): Jean
Addington and Shon W. Lewis
Chapter 7 Course and Outcome (pages 104–141): Wolfram an der
Heiden and Heinz Hafner
Chapter 8 Neurocognitive Impairments in Schizophrenia: Their
Character and Role in Symptom Formation (pages 142–162): Terry
E. Goldberg, Anthony David and James. M. Gold
Chapter 9 The Secondary Schizophrenias (pages 163–184): Thomas
M. Hyde and Maria A. Ron
Chapter 10 Schizophrenia: The Epidemiological Horizon (pages
185–225): Assen Jablensky, James B. Kirkbride and Peter B.
Jones
Chapter 11 Environmental Risk Factors for Schizophrenia (pages
226–244): John J. McGrath and Robin M. Murray
Chapter 12 Classical Genetic Studies of Schizophrenia (pages
245–268): Brien Riley and Kenneth S. Kendler
Chapter 13 Genetic Associations in Schizophrenia (pages
269–288): Michael C. O'Donovan and Michael J. Owen
Chapter 14 Intermediate Phenotypes in Genetic Studies of
Schizophrenia (pages 289–310): Michael F. Egan and Tyrone D.
Cannon
Chapter 15 Electrophysiology of Schizophrenia (pages 311–333):
Georg Winterer and Robert W. McCarley
Chapter 16 Structural Brain Imaging in Schizophrenia and
Related Populations (pages 334–352): Stephen M. Lawrie and
Christos Pantelis
Chapter 17 Functional Brain Imaging in Schizophrenia (pages
353–371): Andreas Meyer?Lindenberg and Edward T. Bullmore
Chapter 18 Neuropathology of Schizophrenia (pages 372–392):
Paul J. Harrison, David A. Lewis and Joel E. Kleinman
Chapter 19 Neurodevelopmental Origins of Schizophrenia (pages
393–412): Daniel R. Weinberger and Pat Levitt
Chapter 20 Dopamine and Schizophrenia (pages 413–432): Anissa
Abi?Dargham and Anthony A. Grace
Chapter 21 Contributions of Glutamate and GABA Systems to the
Neurobiology and Treatment of Schizophrenia (pages 433–461):
John H. Krystal and Bita Moghaddam
Chapter 22 Animal Models of Schizophrenia (pages 462–481):
Barbara K. Lipska and Joseph A. Gogos
Chapter 23 Pharmacology and Neuroscience of Antipsychotic Drugs
(pages 483–514): John L. Waddington, Colm M. P. O'Tuathaigh and
Gary J. Remington
Chapter 24 Principles of Pharmacological Treatment in
Schizophrenia (pages 515–524): Thomas R. E. Barnes and Stephen
R. Marder
Chapter 25 Comparative Efficacy and Effectiveness in the Drug
Treatment of Schizophrenia (pages 525–539): John R. Geddes, T.
Scott Stroup and Jeffrey A. Lieberman
Chapter 26 Approaches to Treatment?Resistant Patients (pages
540–560): Stephan Leucht, Christoph U. Correll and John M.
Kane
Chapter 27 Neurological Complications of Antipsychotic Drugs
(pages 561–576): Peter M. Haddad and Venkata S. Mattay
Chapter 28 Metabolic Adverse Effects Associated with
Antipsychotic Medications (pages 577–597): John W. Newcomer and
Stefan Leucht
Chapter 29 Schizophrenia and Psychosocial Stresses (pages
599–624): Paul E. Bebbington and Elizabeth Kuipers
Chapter 30 Mental Health Services for Patients with
Schizophrenia (pages 625–643): Tom Burns and Bob Drake
Chapter 31 Societal Outcomes in Schizophrenia (pages 644–665):
Iain Kooyman and Elizabeth Walsh
Chapter 32 Psychological Treatment of Psychosis (pages
666–686): Gillian Haddock and Will Spaulding
Chapter 33 Economics of the Treatment of Schizophrenia (pages
687–699): Nancy H. Covell, Susan M. Essock and Linda K. Frisman
fmatter......Page 2
ins......Page 16
ch1......Page 24
ch2......Page 31
ch3......Page 46
ch4......Page 69
ch5......Page 84
ch6......Page 113
ch7......Page 126
ch8......Page 164
ch9......Page 185
ch10......Page 206
ch11......Page 247
ch12......Page 266
ch13......Page 290
ch14......Page 310
ch15......Page 332
ch16......Page 355
ch17......Page 374
ch18......Page 393
ch19......Page 414
ch20......Page 434
ch21......Page 454
ch22......Page 483
ch23......Page 503
ch24......Page 534
ch25......Page 544
ch26......Page 559
ch27......Page 580
ch28......Page 596
ch29......Page 617
ch30......Page 642
ch31......Page 661
ch32......Page 683
ch33......Page 704
index......Page 717