Role of the Sarcoplasmic Reticulum in Smooth Muscle

ROLE OF THE SARCOPLASMIC RETICULUM IN SMOOTH MUSCLE......Page 3
Contents......Page 7
Participants......Page 9
Chair’s introduction......Page 13
Role of the sarcoplasmic reticulum in uterine smooth muscle......Page 18
Discussion......Page 30
Relationship between the sarcoplasmic reticulum and the plasma membrane......Page 38
Discussion......Page 53
General discussion I The role of calmodulin in smooth muscle contraction......Page 60
Ca(2+) signalling and Ca(2+)-activated K(+) channels in smooth muscle......Page 64
Discussion......Page 76
Additional fluxes of activator Ca(2+) accompanying Ca(2+) release from the sarcoplasmic reticulum triggered by InsP(3)-mobilizing agonists......Page 83
Discussion......Page 88
Molecular candidates for capacitative and non-capacitative Ca(2+) entry in smooth muscle......Page 93
Regulation of Ca(2+) entry pathways by both limbs of the phosphoinositide pathway......Page 103
Discussion......Page 113
Calcium release by ryanodine receptors in smooth muscle......Page 120
Discussion......Page 131
Organization of Ca(2+) stores in vascular smooth muscle: functional implications......Page 137
Discussion......Page 149
Molecular basis and physiological functions of dynamic Ca(2+) signalling in smooth muscle cells......Page 154
Discussion......Page 159
Calcium release events in excitation–contraction coupling in smooth muscle......Page 166
Discussion......Page 180
Sarcoplasmic reticulum, calcium waves and myometrial signalling......Page 186
Discussion......Page 194
Sarcoplasmic reticulum and membrane currents......Page 201
Discussion......Page 215
Sarcoplasmic reticulum function and contractile consequences in ureteric smooth muscles......Page 220
Discussion......Page 229
General discussion II The physiological significance of smooth muscle Ca(2+) stores......Page 233
The sarcoplasmic reticulum and smooth muscle function: evidence from transgenic mice......Page 240
Discussion......Page 250
The sarcoplasmic reticulum in disease and smooth muscle dysfunction: therapeutic potential......Page 256
Discussion......Page 266
The sarcoplasmic reticulum: then and now......Page 270
Discussion......Page 280
Final general discussion......Page 284
Index of contributors......Page 289
Subject index......Page 291