Retroviral proteases

Content: 
Contributors to volume 241
Pages vii-viii

Volumes in series
Pages xi-xxv

[1] Expression systems for retroviral proteases Original Research Article
Pages 3-16
Jeffrey Stebbins, Christine Debouck

[2] Genetic approaches designed to minimize cytotoxicity of retroviral protease Original Research Article
Pages 16-29
C.J. Rizzo, B.D. Korant

[3] Host strain selection for bacterial expression of toxic proteins Original Research Article
Pages 29-46
Elizabeth Chen

[4] Assay methods for retroviral proteases Original Research Article
Pages 46-58
Christopher U.T. Hellen

[5] Analysis of human immunodeficiency virus type 1 protease activity in eukaryotic and bacterial cells Original Research Article
Pages 58-69
Andrew H. Kaplan, Marianne Manchester, Lorraine Everitt, Ronald Swanstrom

[6] Synthetic approaches to continuous assays of retroviral proteases Original Research Article
Pages 70-86
Granta A. Krafft, Gary T. Wang

[7] Identification, purification, and cell culture assays of retroviral proteases Original Research Article
Pages 89-104
Klaus Vonder Helm, Sigrid Seelmeier, Alexei Kisselev, Hans Nitschko

[8] Stability of dimeric retroviral proteases Original Research Article
Pages 104-127
Paul L. Darke

[9] Use of steady state kinetic methods to elucidate the kinetic and chemical mechanisms of retroviral proteases Original Research Article
Pages 127-156
Thomas D. Meek, Evelyn J. Rodriguez, Thelma S. Angeles

[10] X-ray structures of retroviral proteases and their inhibitor-bound complexes Original Research Article
Pages 157-177
Dagmar Ringe

[11] Probing structure-function relationships in human immunodeficiency virus type 1 protease via molecular dynamics simulation Original Research Article
Pages 178-192,IN1-IN4,193-195
William E. Harte Jr., David L. Beveridge

[12] Relationships of human immunodeficiency virus protease with eukaryotic aspartic proteases Original Research Article
Pages 195-224
Xin-li Lin, Ying-zhang Lin, Jordan Tang

[13] Processing of retroviral gag polyproteins: An in vitro approach Original Research Article
Pages 227-253
Carol Carter, Gabrielle Zybarth

[14]Subsite preferences of retroviral proteinases Original Research Article
Pages 254-278,IN5-IN12
Ben M. Dunn, Alla Gustchina, Alexander Wlodawer, John Kay

[15] Specificity of retroviral proteases: An analysis of viral and nonviral protein substrates Original Research Article
Pages 279-301
Alfredo G. Tomasselli, Robert L. Heinrikson

[16] Rapid determination of endoprotease specificity using peptide mixtures and Edman degradation analysis Original Research Article
Pages 302-310
Frank R. Masiarz, Bruce A. Malcolm

[17] Design of tight-binding human immunodeficiency virus type 1 protease inhibitors Original Research Article
Pages 311-322,IN13-IN14,323-334
Joseph P. Vacca

[18] Design of symmetry-based, peptidomimetic inhibitors of human immunodeficiency virus protease Original Research Article
Pages 334-354
Dale J. Kempf

[19] Advances in automated docking applied to human immunodeficiency virus type 1 protease Original Research Article
Pages 354-366,IN15-IN16,367-370
Michael D. Miller, Robert P. Sheridan, Simon K. Kearsley, Dennis J. Underwood

[20] Use of molecular dynamics and free energy perturbation calculations in anti-human immunodeficiency virus drug design Original Research Article
Pages 370-384
Margaret A. McCarrick, Peter Kollman

[21] Qualitative study of drug resistance in retroviral protease using structural modeling and site-directed mutagenesis Original Research Article
Pages 385-392,IN17-IN19,393-394
J.Chris Culberson, Bruce L. Bush, Vinod V. Sardana

Author index
Pages 395-419

Subject index
Pages 420-432

Preface
Page ix
Lawrence C. Kuo, Jules A. Shafer