Research in Computational Molecular Biology: 12th Annual International Conference, RECOMB 2008, Singapore, March 30 - April 2, 2008. Proceedings

Front Matter....Pages -
Computational Biology: Its Challenges Past, Present, and Future....Pages 1-2
Bootstrapping the Interactome: Unsupervised Identification of Protein Complexes in Yeast....Pages 3-16
CompostBin: A DNA Composition-Based Algorithm for Binning Environmental Shotgun Reads....Pages 17-28
Reconstructing the Evolutionary History of Complex Human Gene Clusters....Pages 29-49
Ab Initio Whole Genome Shotgun Assembly with Mated Short Reads....Pages 50-64
Orchestration of DNA Methylation....Pages 65-65
 BayCis : A Bayesian Hierarchical HMM for Cis-Regulatory Module Decoding in Metazoan Genomes....Pages 66-81
A Combined Expression-Interaction Model for Inferring the Temporal Activity of Transcription Factors....Pages 82-97
A Fast, Alignment-Free, Conservation-Based Method for Transcription Factor Binding Site Discovery....Pages 98-111
The Statistical Power of Phylogenetic Motif Models....Pages 112-126
Transcriptional Regulation and Cancer Genomics....Pages 127-127
Automatic Recognition of Cells (ARC) for 3D Images of C. elegans ....Pages 128-139
Spectrum Fusion: Using Multiple Mass Spectra for De Novo Peptide Sequencing....Pages 140-153
A Fragmentation Event Model for Peptide Identification by Mass Spectrometry....Pages 154-166
A Bayesian Approach to Protein Inference Problem in Shotgun Proteomics....Pages 167-180
De Novo Sequencing of Nonribosomal Peptides....Pages 181-195
Systems Metabolic Engineering....Pages 196-196
Protein Function Prediction Based on Patterns in Biological Networks....Pages 197-213
Automatic Parameter Learning for Multiple Network Alignment....Pages 214-231
An Integrative Network Approach to Map the Transcriptome to the Phenome....Pages 232-245
Fast and Accurate Alignment of Multiple Protein Networks....Pages 246-256
High-Resolution Modeling of Cellular Signaling Networks....Pages 257-271
At the Origin of Life: How Did Folded Proteins Evolve?....Pages 272-272
Locating Multiple Gene Duplications through Reconciled Trees....Pages 273-284
Rapid and Accurate Protein Side Chain Prediction with Local Backbone Information....Pages 285-299
Algorithms for Joint Optimization of Stability and Diversity in Planning Combinatorial Libraries of Chimeric Proteins....Pages 300-314
DLIGHT – Lateral Gene Transfer Detection Using Pairwise Evolutionary Distances in a Statistical Framework....Pages 315-330
Computation of Median Gene Clusters....Pages 331-345
BCL-2: From Translocation to Therapy....Pages 346-346
Detecting Disease-Specific Dysregulated Pathways Via Analysis of Clinical Expression Profiles....Pages 347-359
Constructing Treatment Portfolios Using Affinity Propagation....Pages 360-371
Bubbles: Alternative Splicing Events of Arbitrary Dimension in Splicing Graphs....Pages 372-395
More Efficient Algorithms for Closest String and Substring Problems....Pages 396-409
Disruption of a Transcriptional Regulatory Pathway Contributes to Phenotypes in Carriers of Ataxia Telangiectasia....Pages 410-410
Accounting for Non-genetic Factors Improves the Power of eQTL Studies....Pages 411-422
Effects of Genetic Divergence in Identifying Ancestral Origin Using HAPAA....Pages 423-423
On the Inference of Ancestries in Admixed Populations....Pages 424-433
Increasing Power in Association Studies by Using Linkage Disequilibrium Structure and Molecular Function as Prior Information....Pages 434-434
Panel Construction for Mapping in Admixed Populations Via Expected Mutual Information....Pages 435-449
Constructing Level-2 Phylogenetic Networks from Triplets....Pages 450-462
Accurate Computation of Likelihoods in the Coalescent with Recombination Via Parsimony....Pages 463-477
Back Matter....Pages -