Research in Computational Molecular Biology: 23rd Annual International Conference, RECOMB 2019, Washington, DC, USA, May 5-8, 2019, Proceedings

Front Matter ....Pages i-xiv
 An Efficient, Scalable and Exact Representation of High-Dimensional Color Information Enabled via de Bruijn Graph Search  (Fatemeh Almodaresi, Prashant Pandey, Michael Ferdman, Rob Johnson, Rob Patro)....Pages 1-18
 Identifying Clinical Terms in Free-Text Notes Using Ontology-Guided Machine Learning  (Aryan Arbabi, David R. Adams, Sanja Fidler, Michael Brudno)....Pages 19-34
 ModHMM: A Modular Supra-Bayesian Genome Segmentation Method  (Philipp Benner, Martin Vingron)....Pages 35-50
 Learning Robust Multi-label Sample Specific Distances for Identifying HIV-1 Drug Resistance  (Lodewijk Brand, Xue Yang, Kai Liu, Saad Elbeleidy, Hua Wang, Hao Zhang)....Pages 51-67
 MethCP: Differentially Methylated Region Detection with Change Point Models  (Boying Gong, Elizabeth Purdom)....Pages 68-84
 On the Complexity of Sequence to Graph Alignment  (Chirag Jain, Haowen Zhang, Yu Gao, Srinivas Aluru)....Pages 85-100
 Minimization-Aware Recursive \\(K^{*}\\) (\\({ MARK}^{*}\\)): A Novel, Provable Algorithm that Accelerates Ensemble-Based Protein Design and Provably Approximates the Energy Landscape  (Jonathan D. Jou, Graham T. Holt, Anna U. Lowegard, Bruce R. Donald)....Pages 101-119
 Sparse Binary Relation Representations for Genome Graph Annotation  (Mikhail Karasikov, Harun Mustafa, Amir Joudaki, Sara Javadzadeh-No, Gunnar Rätsch, André Kahles)....Pages 120-135
 How Many Subpopulations Is Too Many? Exponential Lower Bounds for Inferring Population Histories  (Younhun Kim, Frederic Koehler, Ankur Moitra, Elchanan Mossel, Govind Ramnarayan)....Pages 136-157
 Efficient Construction of a Complete Index for Pan-Genomics Read Alignment  (Alan Kuhnle, Taher Mun, Christina Boucher, Travis Gagie, Ben Langmead, Giovanni Manzini)....Pages 158-173
 Tumor Copy Number Deconvolution Integrating Bulk and Single-Cell Sequencing Data  (Haoyun Lei, Bochuan Lyu, E. Michael Gertz, Alejandro A. Schäffer, Xulian Shi, Kui Wu et al.)....Pages 174-189
 OMGS: Optical Map-Based Genome Scaffolding  (Weihua Pan, Tao Jiang, Stefano Lonardi)....Pages 190-207
 Fast Approximation of Frequent k-mers and Applications to Metagenomics  (Leonardo Pellegrina, Cinzia Pizzi, Fabio Vandin)....Pages 208-226
 De Novo Clustering of Long-Read Transcriptome Data Using a Greedy, Quality-Value Based Algorithm  (Kristoffer Sahlin, Paul Medvedev)....Pages 227-242
 A Sticky Multinomial Mixture Model of Strand-Coordinated Mutational Processes in Cancer  (Itay Sason, Damian Wojtowicz, Welles Robinson, Mark D. M. Leiserson, Teresa M. Przytycka, Roded Sharan)....Pages 243-255
 Disentangled Representations of Cellular Identity  (Ziheng Wang, Grace H. T. Yeo, Richard Sherwood, David Gifford)....Pages 256-271
 RENET: A Deep Learning Approach for Extracting Gene-Disease Associations from Literature  (Ye Wu, Ruibang Luo, Henry C. M. Leung, Hing-Fung Ting, Tak-Wah Lam)....Pages 272-284
Back Matter ....Pages 285-337