Reproductive and Hormonal Aspects of Systemic Autoimmune Diseases, Volume 4 (Handbook of Systemic Autoimmune Diseases)

Cover......Page 1
Reproductive and Hormonal Aspects of Systemic Autoimmune Diseases......Page 4
Contents......Page 12
Series Editor......Page 6
Volume Editors......Page 8
List of Contributors......Page 10
Introduction......Page 14
Etiology/pathogenesis......Page 16
References......Page 21
A role of tolerance in healthy pregnancy......Page 24
A normal physiological condition......Page 25
Scleroderma......Page 26
Myositis......Page 32
Lichen planus......Page 33
Microchimerism and HLA associations in autoimmune diseases......Page 34
HLA compatibility between donor and host cells in autoimmune disease......Page 35
Maternal antibodies......Page 36
References......Page 37
The epidemiology and etiology of infertility......Page 42
Treatment of infertility......Page 43
Systemic lupus erythematosus......Page 44
Antithyroid antibodies......Page 45
Rheumatoid arthritis......Page 46
Addison’s disease and the autoimmune polyglandular syndromes......Page 47
Autoimmune premature ovarian failure......Page 48
Antiphospholipid antibody syndrome......Page 49
The effects of immunosuppressive and anti-inflammatory medications on fertility......Page 50
References......Page 52
Gestational diabetes and hypertension......Page 56
Preterm births......Page 57
SLE diagnosed during pregnancy......Page 58
Pathogenesis......Page 59
Blood pressure......Page 60
Fetal ultrasound......Page 61
Biochemistry, serologic, immunology......Page 62
Differential diagnosis......Page 63
Treatment......Page 65
Moderate lupus activity......Page 66
Key points......Page 67
References......Page 68
Prevalence and Epidemiology......Page 72
Etiology/pathogenesis......Page 73
Pregnancy loss......Page 75
Catastrophic vascular occlusion syndrome......Page 76
Blood......Page 77
Pregnancy......Page 78
Treatment......Page 79
Pregnancy......Page 80
APS with previous thrombosis......Page 81
APS pregnancy in ’refractory’ cases......Page 82
Complications and prognosis......Page 83
Key points......Page 84
References......Page 85
Effect of the oral contraceptive and parity in the development of RA......Page 90
Effects of pregnancy on the disease......Page 91
Disease treatment during pregnancy......Page 92
Systemic sclerosis......Page 93
Effects of the disease on pregnancy......Page 94
Undifferentiated connective tissue diseases......Page 95
Effects of the disease on pregnancy......Page 96
The effects of the disease on pregnancy......Page 97
Mixed connective tissue diseases......Page 98
Effects of pregnancy on the disease and vice versa......Page 99
Effects of pregnancy on the disease and vice versa......Page 100
Effects of pregnancy on the disease and vice versa......Page 101
Key points......Page 102
References......Page 103
Clinical presentation......Page 108
Diagnostic considerations......Page 109
Therapeutic options......Page 110
References......Page 112
Introduction......Page 114
Risk factor B drugs......Page 115
Risk factor C drugs......Page 117
Risk factor D drugs......Page 120
Risk X Drugs......Page 121
References......Page 122
Influence of maternal disease......Page 124
Influence of maternal autoantibodies......Page 125
Anti-Ro/SS-A antibodies......Page 126
Anti-phospholipid antibodies......Page 127
Outcome of children exposed to immunosuppressive drugs in pregnancy......Page 128
Genetic background......Page 129
Key points......Page 130
References......Page 131
Non-hormonal methods......Page 136
Hormonal methods......Page 137
Adverse effects of hormonal contraceptives......Page 139
Hormonal contraceptives and venous thrombosis......Page 140
Hormonal contraceptives and arterial thrombosis......Page 141
Antiphospholipid antibody......Page 142
Hormonal contraceptives and aPLs......Page 143
Systemic lupus erythematosus......Page 144
Rheumatoid arthritis......Page 146
Other connective tissue diseases......Page 147
Key points......Page 148
References......Page 149
Lichen sclerosis......Page 154
Autoimmune disorders that may affect the vulva......Page 155
Vaginitis......Page 157
Human papillomavirus and precancerous lesions of the cervix......Page 160
Diagnosis and management......Page 161
Herpes simplex virus......Page 162
Classification and diagnosis of female sexual dysfunction......Page 163
Sexual dysfunction among patients with autoimmune disorders......Page 164
Multiple sclerosis......Page 165
Systemic lupus erythematosus......Page 166
Rheumatoid arthritis and ankylosing spondylitis......Page 167
Sexual desire disorders......Page 168
Orgasmic disorder......Page 170
References......Page 171
Osteoporosis......Page 174
Treatment......Page 179
Thiazide diuretics......Page 180
Bisphosphonates......Page 181
Parathyroid hormone and growth factors......Page 183
Rheumatoid arthritis......Page 184
Treatment......Page 185
Systemic lupus erythematosus......Page 186
Hormone replacement therapy......Page 187
References......Page 189
Further Reading......Page 192
Index......Page 194