Renal Cell Carcinoma: Translational Biology, Personalized Medicine, and Novel Therapeutic Targets

Front Matter....Pages i-xi
Front Matter....Pages 1-1
The Genetic Basis of Kidney Cancer and Implications for Targeted Therapies....Pages 3-25
Molecular Biology of Clear Cell Renal Carcinoma....Pages 27-47
HIF Biology in RCC: Implications for Signaling, Disease Progression, and Treatment....Pages 49-68
Tissue Biomarkers in Renal Cell Carcinoma: Intermediate Endpoints in the Selection of Targeted Agents for RCC....Pages 69-89
Molecular Characterization of Renal Cell Carcinoma....Pages 91-111
Front Matter....Pages 113-113
Targeting the VEGF Pathway in Renal Cell Carcinoma....Pages 115-133
Angiopoietins and Other Non-VEGF Antiangiogenic Targets in Advanced Renal Cell Carcinoma....Pages 135-160
Research Translation and Personalized Medicine....Pages 161-191
Epigenetic Targeting and Histone Deacetylase Inhibition in RCC....Pages 193-211
C-MET as a Novel Target for the Treatment of Renal Cell Carcinoma....Pages 213-238
Characterizing and Modulating the Tumor Microenvironment in Renal Cell Carcinoma: Potential Therapeutic Strategies....Pages 239-252
Carbonic Anhydrase IX: Its Role as a Biomarker, Diagnostic, and Therapeutic Target in Renal Cell Carcinoma....Pages 253-270
Presurgical Therapy for Renal Cell Carcinoma and Implications for Window-of-Opportunity Trials....Pages 271-282
Mechanisms of Resistance to VEGF-Directed Therapy and Implications for Future Trial Design....Pages 283-303
Vaccine-Based Immunotherapy and Targeting the Tumor Microenvironment in Renal Cell Carcinoma....Pages 305-322
Back Matter....Pages 323-327