Relaxin 2000: Proceedings of the Third International Conference on Relaxin & Related Peptides 22–27 October 2000, Broome, Australia

Front Matter....Pages i-xxii
Front Matter....Pages 1-1
Hooked on relaxin: A career-long love affair with a fickle and elusive hormone....Pages 3-24
Front Matter....Pages 25-25
Effects of relaxin on the cervix and the vagina in the rat....Pages 27-34
Relaxin retards apoptosis in the cervix and the vagina during pregnancy in rats....Pages 35-40
Synthesis and function of relaxin in human endometrium....Pages 41-45
Analysis of relaxin deficient mice....Pages 47-51
Relaxin is a key regulatory peptide in the reproductive tract of the pregnant tammar wallaby, Macropus eugenii ....Pages 53-58
Characterization of preprorelaxin in a marsupial, the tammar wallaby Macropus eugenii ....Pages 59-62
Front Matter....Pages 63-63
Relaxin induces specific alterations in gene expression in the human endometrium....Pages 65-72
Relaxin is an important factor for uterine differentiation and implantation in the marmoset monkey....Pages 73-82
Relaxin and porcine uterine growth and remodeling....Pages 83-89
Relaxin and placental dysfunction in the horse....Pages 91-99
Intersection of the relaxin and estrogen signalling pathways in the uterus....Pages 101-108
Relaxin up-regulates rat uterine vascular endothelial growth factor mRNA in vivo ....Pages 109-113
Comparative aspects of relaxin and relaxin-like factor (Insulin 3) in the placental trophoblast....Pages 115-120
Secretion of matrix metalloproteinase-2, tissue inhibitor of metalloproteinase-1 and human chorionic gonadotropin by cytotrophoblastic cells: Is there a regulation by relaxin?....Pages 121-125
Molecular remodelling of members of the relaxin family during primate evolution....Pages 127-128
Relaxin in the hamster....Pages 129-136
Front Matter....Pages 137-137
Relaxin: a luteotrophic factor in the marmoset corpus luteum....Pages 139-144
Isolation and bioactivity of relaxin from the tammar wallaby ( Macropus eugenii )....Pages 145-146
Possible role of the IGF family for the bovine ovarian function....Pages 147-148
Front Matter....Pages 137-137
Identification of consensus sequences in the rat relaxin promoter which bind nuclear proteins....Pages 149-150
Front Matter....Pages 151-151
Effects of relaxin on experimentally-induced myocardial infarction. Is this hormone a natural shield against cardiovascular ischemic disease?....Pages 153-157
Systemic relaxin administration stimulates angiogenic cytokine expression and vessel formation in a rat myocardial infarct model....Pages 159-167
Is relaxin the “elusive” vasodilator of pregnancy?....Pages 169-176
Reproductive hormones and blood pressure during pregnancy....Pages 177-182
The effect of relaxin on vascular function in rat aorta....Pages 183-184
Cardiovascular phenotypes of relaxin knockout mice: Importance of gender....Pages 185-188
Front Matter....Pages 189-189
Relaxin action on and in the brain....Pages 191-199
Neurons and neural pathways mediating the actions of circulating relaxin on the brain....Pages 201-208
Identification of relaxin and relaxin responsive cells in the rat brain....Pages 209-214
Effect of Relaxin on the Expression of Angiotensin II Receptors in the Subfornical Organ of Rats during Pregnancy....Pages 215-216
Relaxin and relaxin receptors in brain....Pages 217-218
Front Matter....Pages 219-219
Relaxin knockout mice demonstrate delayed growth and have underdeveloped male reproductive tracts....Pages 221-223
Relaxin expression and binding in the rat prostate....Pages 225-228
Front Matter....Pages 229-229
Chemical synthesis of relaxin analogues: Current status and future developments....Pages 231-236
A new synthesis of human 2 relaxin using selective bridging....Pages 237-238
N α - mono -biotinylated rat relaxin: synthesis and activity....Pages 239-240
Design, synthesis and biological activity of template-assembled peptidic mimetics of rat relaxin....Pages 241-242
Chemical synthesis and relaxin activity of analogues of ovine Insulin 3 containing specific B-chain residue replacements....Pages 243-246
Chemical synthesis and biological activity of ovine Insulin 3, a relaxin structural homologue....Pages 247-248
Front Matter....Pages 229-229
Solid phase syntheses of rat prorelaxin C-peptides (1–73) and (76–101)....Pages 249-250
Chemical synthesis and relaxin activity of rat Insulin 3....Pages 251-252
Front Matter....Pages 253-253
Structure-activity relationships of relaxin and relaxin-like factor/insulin 3....Pages 255-260
Relaxin bioassays....Pages 261-270
Bioassays for relaxin and relaxin-related peptides....Pages 271-272
A highly sensitive homologous human relaxin ELISA....Pages 273-275
Front Matter....Pages 277-277
Relaxin and scaffolding proteins in signalling crosstalk....Pages 279-283
Mechanism of action of relaxin in human cervix....Pages 285-289
Myometrial relaxant action of relaxin....Pages 291-299
The use of biosensor technology to search for orphan biomolecules: towards the relaxin receptor....Pages 301-308
Relaxin signal transduction couples tyrosine phosphorylation to cAMP upregulation....Pages 309-315
Relaxin activating effect on the adenylyl cyclase and glycogen synthase in muscles of mammals and molluscs....Pages 317-319
The regulatory role of protein kinase C in insulin signal transduction via adenylyl cyclase signalling system....Pages 321-323
Front Matter....Pages 325-325
The Relaxin-Like Factor: from gene to physiology....Pages 327-335
Molecular genetics of Insulin3 ....Pages 337-345
Testicular descent in rats: a role for relaxin?....Pages 347-348
The Relaxin-Like Factor (Insulin 3) is highly expressed in the ruminant ovary: A putative ruminant relaxin?....Pages 349-356
Characterization of the rat Relaxin Like Factor/JAK3 gene region....Pages 357-358
Relaxin-Like Factor is differentially expressed in the normal and neoplastic human mammary gland....Pages 359-360
Relaxin-Like Factor in the human thyroid....Pages 361-362
Front Matter....Pages 325-325
The genomics of Insulin 5....Pages 363-369
Front Matter....Pages 371-371
Relaxin clinical trials in systemic sclerosis....Pages 373-381
Relaxin decreases renal interstitial fibrosis: A novel treatment to slow the progression of kidney disease?....Pages 383-388
Relaxin modulates fibrillin-2, but not fibrillin-1, gene expression by human dermal fibroblasts....Pages 389-392
Effect of relaxin on normal and impaired wound healing in rodents....Pages 393-397
The formation of amyloid fibrils by relaxin....Pages 399-404
Front Matter....Pages 405-405
Pelvic girdle relaxation, developmental dysplasia of the hip and the hormone relaxin — are they loosely connected?....Pages 407-413
Back pain in IVF-induced and spontaneous pregnancies....Pages 415-420
Immunohistochemical detection of relaxin binding to ligaments of the thumb and knee....Pages 421-424
Preterm delivery predicted by serum relaxin....Pages 425-428
High serum concentrations of relaxin correlate with dissemination of breast cancer....Pages 429-435
Relationship of serum relaxin levels to knee joint laxity in female athletes....Pages 437-439
Relaxin in the new Millennium — a round table discussion....Pages 441-452
Back Matter....Pages 453-460