Regulatory RNAs

CoverPage......Page 1
FrontMatter......Page 2
TitlePage......Page 4
CopyRight......Page 5
Participants_Lists......Page 6
Pariticipants_Figures......Page 15
Foreword......Page 22
Sponsors......Page 23
Contents......Page 24
Small RNA Regulators and the Bacterial Response to Stress......Page 28
Short Silencing RNA: The Dark Matter of Genetics?......Page 40
Misexpression of the Caenorhabditis elegans miRNA let-7Is Sufficient to Drive Developmental Programs......Page 48
Function and Localization of MicroRNAs in Mammalian Cells......Page 56
The RNAi Pathway Initiated by Dicer-2 in Drosophila......Page 66
Molecular Mechanism of Target RNA Transcript Recognitionby Argonaute-Guide Complexes......Page 72
Substrate Selectivity of Exportin 5 and Dicer in theBiogenesis of MicroRNAs......Page 86
The Argonautes......Page 94
Structure of Dicer and Mechanistic Implications for RNAi......Page 100
Structural Biology of RNA Silencing andIts Functional Implications......Page 108
Systemic RNAi in Caenorhabditis elegans......Page 122
Transcriptional Landscape of the Human and Fly Genomes:Nonlinear and Multifunctional Modular Model of Transcriptomes......Page 128
Novel Transcribed Regions in the Human Genome......Page 138
Computational Analysis of RNAs......Page 144
MicroRNAs in Search of a Target......Page 156
RNomics: Identification and Function of SmallNon-Protein-coding RNAs in Model Organisms......Page 162
Drosophila Genome-wide RNAi Screens:Are They Delivering the Promise?......Page 168
Deep Conservation of MicroRNA-target Relationships and3′UTR Motifs in Vertebrates, Flies, and Nematodes......Page 176
Organ Polarity in Plants Is Specified through the OpposingActivity of Two Distinct Small Regulatory RNAs......Page 184
The Function of RNAi in Plant Development......Page 192
rasiRNAs,DNA Damage, and Embryonic Axis Specification......Page 198
Architecture of a MicroRNA-controlled Gene RegulatoryNetwork That Diversifies Neuronal Cell Fates......Page 208
The Caenorhabditis elegans Argonautes ALG-1 and ALG-2:Almost Identical yet Different......Page 216
MicroRNA Function and Mechanism: Insights from Zebra Fish......Page 222
MicroRNAs and Hematopoietic Differentiation......Page 232
Expression and Suppression of Human Telomerase RNA......Page 238
RNA as a Flexible Scaffold for Proteins:Yeast Telomerase and Beyond......Page 244
Telomerase RNA Levels Limit the Telomere Length Equilibrium......Page 252
Sensing Metabolic Signals with Nascent RNA Transcripts......Page 258
Genetic Control by cis-Acting Regulatory RNAs in Bacillussubtilis: General Principles and Prospects for Discovery......Page 266
A Mg2+-responding RNA That Controls the Expressionof a Mg2+ Transporter......Page 278
Structural Studies of the Purine and SAMBinding Riboswitches......Page 286
Turnover and Function of Noncoding RNA Polymerase II Transcripts......Page 302
How Does RNA Editing Affect dsRNA-mediatedGene Silencing?......Page 312
How a Small DNA Virus Uses dsRNA but Not RNAi toRegulate Its Life Cycle......Page 320
Regulation of Two Key Nuclear Enzymatic Activities by the7SK Small Nuclear RNA......Page 328
The SMN Complex: An Assembly Machine for RNPs......Page 340
Developing Global Insight into RNA Regulation......Page 348
Regulation of Alternative Splicing by snoRNAs......Page 356
Measuring the Rates of Transcriptional Elongation in theFemale Drosophila melanogaster Germ Line by Nuclear Run-on......Page 362
Polymorphic MicroRNA–Target Interactions:A Novel Source of Phenotypic Variation......Page 370
Expression and Function of MicroRNAs inViruses Great and Small......Page 378
Expression and Function of MicroRNAs Encoded by Kaposi’sSarcoma-associated Herpesvirus......Page 384
Relationship between Retroviral Replication and RNAInterference Machineries......Page 392
Positive and Negative Modulation of Viral and Cellular mRNAsby Liver-specific MicroRNA miR-122......Page 396
The Challenge of Viral snRNPs......Page 404
MSL Complex Associates with Clusters of Actively TranscribedGenes along the Drosophila Male X Chromosome......Page 412
Noncoding RNAs of the H/ACA Family......Page 422
Biogenesis and Intranuclear Trafficking of HumanBox C/D and H/ACA RNPs......Page 434
RNA and Protein Actors in X-Chromosome Inactivation......Page 446
X-Chromosome Kiss and Tell: How the XsGo Their Separate Ways......Page 456
Genetic Analyses of DNA Methyltransferasesin Arabidopsis thaliana......Page 466
Part 10: Summary......Page 476
Studies on the Mechanism of RNAi-dependentHeterochromatin Assembly......Page 488
Cell Biology of the Arabidopsis Nuclear siRNA Pathway forRNA-directed Chromatin Modification......Page 500
A Paragenetic Perspective on Integration of RNA Silencing intothe Epigenome and Its Role in the Biology of Higher Plants......Page 508
Slicing and Spreading of HeterochromaticSilencing by RNA Interference......Page 524
Molecular Chaperones and Quality Control inNoncoding RNA Biogenesis......Page 532
Stress-induced Reversal of MicroRNA Repression and mRNAP-body Localization in Human Cells......Page 540
MicroRNAs Silence Gene Expression by Repressing ProteinExpression and/or by Promoting mRNA Decay......Page 550
MicroRNAs, mRNAs, and Translation......Page 558
Regulation of Poly(A)-binding Protein throughPABP-interacting Proteins......Page 564
Two Distinct Conformations of the Conserved RNA-richDecoding Center of the Small Ribosomal Subunit AreRecognized by tRNAs and Release Factors......Page 572
The Expanding Universe of Noncoding RNAs......Page 578
Author Index......Page 592
Subject Index......Page 594